Works Published in 2015
Displaying works 21 - 40 of 45 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2015 journal article
Mitochondrial DNA Fragmentation as a Molecular Tool to Monitor Thermal Processing of Plant-Derived, Low-Acid Foods, and Biomaterials
Journal of Food Science, 80(8), M1804–M1814.
author keywords: mitochondrial DNA; quantitative PCR; thermal processing
MeSH headings : Clostridium botulinum / isolation & purification; DNA Damage; DNA Fragmentation; DNA Primers; DNA, Mitochondrial / genetics; DNA, Mitochondrial / isolation & purification; DNA, Plant / genetics; DNA, Plant / isolation & purification; Food Contamination / analysis; Food Handling / methods; Food Microbiology; Fruit; Genes, Plant; Geobacillus stearothermophilus / isolation & purification; Hot Temperature; Ipomoea batatas / microbiology; Linear Models; Plant Proteins / genetics; Reproducibility of Results; Spores, Bacterial / isolation & purification; Vegetables
TL;DR:
Data is presented as proof-of-concept for a molecular tool that can be used as a rapid, presumptive method for monitoring thermal processing in low-acid plant products.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2015 journal article
Poultry Body Temperature Contributes to Invasion Control through Reduced Expression of Salmonella Pathogenicity Island 1 Genes in Salmonella enterica Serovars Typhimurium and Enteritidis
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 81(23), 8192–8201.
MeSH headings : Animals; Cecum / microbiology; Cecum / physiology; Chickens; Genomic Islands; Liver / microbiology; Liver / physiology; Poultry Diseases / genetics; Poultry Diseases / metabolism; Poultry Diseases / microbiology; Salmonella Infections, Animal / genetics; Salmonella Infections, Animal / metabolism; Salmonella Infections, Animal / microbiology; Salmonella enteritidis / genetics; Salmonella enteritidis / physiology; Salmonella typhimurium / genetics; Salmonella typhimurium / physiology; Spleen / microbiology; Spleen / physiology; Temperature
TL;DR:
In vivo experiments using chicks demonstrated that numbers of viable S. Typhimurium or S. Enteritidis bacteria within the liver and spleen organ sites were ≥4 orders of magnitude lower than those within the ceca, indicating poor survival within these tissues or a reduced capacity to traverse the host epithelial layer and reach liver/spleen sites or both.
(via Semantic Scholar)
aem.asm.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 article
Is His54 a gating residue for the ferritin ferroxidase site?
Bernacchioni, C., Ciambellotti, S., Theil, E. C., & Turano, P. (2015, September). BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, Vol. 1854, pp. 1118–1122.
author keywords: Ferritin; Ferroxidase site; Reaction kinetics; Mutagenesis
MeSH headings : Binding Sites; Ceruloplasmin / chemistry; Crystallography, X-Ray; Ferritins / chemistry; Histidine / chemistry; Histidine / metabolism; Iron / chemistry
TL;DR:
The data here reported are consistent with a role for His54 as a metal ion trap that maintains the correct levels of access of iron to the active site and taking advantage of the comparative sequence analysis of other ferritins.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Intravenous Cardiac Stem Cell-Derived Exosomes Ameliorate Cardiac Dysfunction in Doxorubicin Induced Dilated Cardiomyopathy
STEM CELLS INTERNATIONAL, 2015.
TL;DR:
Mice receiving CSC-XOs showed improved heart function via echocardiography, as well as decreased apoptosis and fibrosis, and mice showed no adverse immune reaction, showing promise for overcoming the limitations of stem cells and improving cardiac therapies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Fe2+ substrate transport through ferritin protein cage ion channels influences enzyme activity and biomineralization
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 20(6), 957–969.
author keywords: Ferritin; Iron oxidation; Ion channels; Crystal structure; Electrostatics; Di-iron center; Diferric peroxo; Caged iron-oxy biomineral; Oxidoreductase enzyme reactivity
MeSH headings : Amino Acid Substitution; Crystallography, X-Ray; Ferritins / metabolism; Ferritins / ultrastructure; Ferrous Compounds / metabolism; Ion Channels / metabolism; Ion Channels / ultrastructure; Iron / chemistry; Kinetics; Protein Structure, Secondary
TL;DR:
The contributions of ion channel size and structure to ferritin activity reflect metal ion transport in ion channels are precisely regulated both in Ferritin protein nanocages and membranes of living cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Elucidation of Xylem-Specific Transcription Factors and Absolute Quantification of Enzymes Regulating Cellulose Biosynthesis in Populus trichocarpa
JOURNAL OF PROTEOME RESEARCH, 14(10), 4158–4168.
author keywords: shotgun discovery proteomics; absolute quantification; PC-IDMS; cellulose biosynthesis; transcription factor; targeted mass spectrometiry; SRM
MeSH headings : Carbohydrate Metabolism; Cellulose / biosynthesis; Cellulose / genetics; Chromatography, Liquid; Gene Expression Regulation, Plant; Molecular Sequence Annotation; Plant Proteins / genetics; Plant Proteins / isolation & purification; Plant Proteins / metabolism; Populus / genetics; Populus / metabolism; Proteome / genetics; Proteome / isolation & purification; Proteome / metabolism; Proteomics; Tandem Mass Spectrometry; Transcription Factors / genetics; Transcription Factors / isolation & purification; Transcription Factors / metabolism; Wood / chemistry; Wood / metabolism; Xylem / genetics; Xylem / metabolism
TL;DR:
The study described herein sought to identify the proteins directly involved in cellulose biosynthesis during wood formation in Populus trichocarpa along with known xylem-specific transcription factors involved in regulating these key proteins.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
9. Industry, Innovation and Infrastructure
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Defining multiple, distinct, and shared spatiotemporal patterns of DNA replication and endoreduplication from 3D image analysis of developing maize (Zea mays L.) root tip nuclei
PLANT MOLECULAR BIOLOGY, 89(4-5), 339–351.
author keywords: Cell cycle; DNA synthesis; Grass
MeSH headings : Cell Nucleus / genetics; Cell Nucleus / metabolism; DNA Replication / genetics; DNA Replication Timing / genetics; DNA, Plant / biosynthesis; DNA, Plant / genetics; Endoreduplication / genetics; Genes, Plant; Imaging, Three-Dimensional; Meristem / genetics; Meristem / growth & development; Meristem / metabolism; Models, Biological; S Phase / genetics; Zea mays / genetics; Zea mays / growth & development; Zea mays / metabolism
TL;DR:
3D quantitative analysis of DNA replication and endoreduplication in nuclei from pulse-labeled developing maize root tips revealed that maize euchromatin exists as an intermingled mixture of two components distinguished by their condensation state and replication timing.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 journal article
Coordinated regulation of Nrf2 and histone H3 serine 10 phosphorylation in arsenite-activated transcription of the human heme oxygenase-1 gene
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS, 1849(10), 1277–1288.
author keywords: Nrf2; Histone; Epigenetic; Arsenic; HO-1; Antioxidant response element
MeSH headings : Animals; Antioxidant Response Elements / genetics; Arsenites / pharmacology; Gene Expression Regulation, Enzymologic; Heme Oxygenase-1 / biosynthesis; Heme Oxygenase-1 / genetics; Heme Oxygenase-1 / metabolism; Histones / genetics; Histones / metabolism; Humans; Keratinocytes / metabolism; Mice; NF-E2-Related Factor 2 / genetics; NF-E2-Related Factor 2 / metabolism; Oxidative Stress / genetics; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Signal Transduction; Transcriptional Activation / drug effects; Transcriptional Activation / genetics
TL;DR:
It is proposed that Nrf2 may influence H3S10 phosphorylation at the HO-1 ARE and additional promoter regions, which highlights the complex interplay between NRF2 and H 3S10osphorylation in arsenite-activatedHO-1 transcription.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Elevated cholesteryl ester transfer protein (CETP) activity, a major determinant of the atherogenic dyslipidemia, and atherosclerotic cardiovascular disease in South Asians
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY, 22(4), 468–477.
author keywords: Cholesteryl ester transfer protein (CETP); HDL; LDL; atherogenic dyslipoproteinemia; atherosclerotic cardiovascular diseases; South Asians
MeSH headings : Adult; Aged; Asia / ethnology; Asian People; Atherosclerosis / blood; Atherosclerosis / diagnosis; Atherosclerosis / ethnology; Biomarkers / blood; Canada / epidemiology; Cholesterol Ester Transfer Proteins / blood; Cholesterol, HDL / blood; Cholesterol, LDL / blood; Cross-Sectional Studies; Dyslipidemias / blood; Dyslipidemias / diagnosis; Dyslipidemias / ethnology; Europe / ethnology; Female; Health Status Disparities; Humans; Male; Middle Aged; Risk Factors; Severity of Illness Index; Triglycerides / blood; Up-Regulation; White People
TL;DR:
Novel associations are identified between elevated CETP activity and the triad of quantitative and qualitative lipoprotein abnormalities in the atherogenic dyslipidemia in South Asia, a major contributor of increased atherosclerotic cardiovascular diseases in South Asians.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Development of a tandem affinity phosphoproteomic method with motif selectivity and its application in analysis of signal transduction networks
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 988, 166–174.
author keywords: Phosphopeptide enrichment; Liquid chromatography; Mass spectrometry; Motif analysis; Pathway analysis
MeSH headings : Amino Acid Sequence; Chromatography, Liquid / methods; Molecular Sequence Data; Phosphopeptides / analysis; Phosphopeptides / chemistry; Proteomics / methods; Signal Transduction / physiology; Tandem Mass Spectrometry / methods
TL;DR:
A multi-dimensional method incorporating electrostatic repulsion-hydrophilic interaction chromatography (ERLIC) with tandem IMAC/TiO2 enrichment for subsequent phosphopeptide identification by LC/MS/MS and biological functions that were over-represented at each PDGF stimulation time point illustrate the feasibility of this approach in quantitative phosphoproteomic studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 article
Teaching old drugs new tricks: Addressing resistance in Francisella
Feldmann, E. A., & Cavanagh, J. (2015, July 4). VIRULENCE, Vol. 6, pp. 414–416.
MeSH headings : Animals; Biofilms / drug effects; Female; Francisella / drug effects; Maprotiline / chemistry; Maprotiline / pharmacology; Protein Kinases / metabolism; Tularemia / drug therapy
TL;DR:
A proposed model suggests that Francisella sensor kinases may not necessarily discriminate for a single response regulator partner, but rather phosphorylate their targets more “promiscuously”.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Membrane-Permeabilizing Activity of Reverse-Amide 2-Aminoimidazole Antibiofilm Agents Against Acinetobacter baumannii
CURRENT DRUG DELIVERY, 12(2), 223–230.
author keywords: 2-aminoimidazole; Acinetobacter baumannii; biofilm; membrane permeabilization; reverse amide; SEM
MeSH headings : Acinetobacter baumannii / drug effects; Amides / chemistry; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Biofilms / drug effects; Cell Membrane Permeability / drug effects; Cells, Cultured; Cross Infection; Imidazoles / chemistry; Imidazoles / pharmacology; Microbial Sensitivity Tests
TL;DR:
A model is proposed that describes how the structure of RA-2AI allows it to insert itself into and disrupt the fluidity of the membrane, creating an opportunity for increased molecular permeability.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
A VALENTINE-SHAPED CARDIAC SILHOUETTE IN FELINE THORACIC RADIOGRAPHS IS PRIMARILY DUE TO LEFT ATRIAL ENLARGEMENT
VETERINARY RADIOLOGY & ULTRASOUND, 56(3), 245–250.
author keywords: atrium; cat; cardiomegaly; radiography; valentine shaped
MeSH headings : Animals; Cardiomegaly / diagnostic imaging; Cardiomegaly / etiology; Cardiomegaly / veterinary; Cat Diseases / diagnostic imaging; Cat Diseases / etiology; Cats; Cross-Sectional Studies; Echocardiography / veterinary; Female; Heart Atria / diagnostic imaging; Male; North Carolina; Radiography; Retrospective Studies
TL;DR:
The hypothesis that a valentine-shaped cardiac silhouette in radiographs is due primarily to left atrial enlargement in cats is supported, with right atrial enlargeement only impacting the shape if concurrent with severe left atri enlargement.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Production and characterization of recombinant perdeuterated cholesterol oxidase
ANALYTICAL BIOCHEMISTRY, 485, 102–108.
author keywords: Flavoenzyme; Perdeuteration; Thermal stability; Protein expression; Enzyme kinetics; Protein structure
MeSH headings : Cholesterol Oxidase / biosynthesis; Cholesterol Oxidase / chemistry; Cholesterol Oxidase / genetics; Crystallography, X-Ray; Deuterium / chemistry; Escherichia coli / chemistry; Escherichia coli / enzymology; Escherichia coli / genetics; Isotope Labeling / methods; Recombinant Proteins / biosynthesis; Recombinant Proteins / chemistry; Recombinant Proteins / genetics
TL;DR:
Structural and functional studies indicate that the perdeuterated protein is suitable for structural studies by neutron crystallography directed at understanding the role of hydrogen atoms in enzyme catalysis.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2015 journal article
Phosphorylation is an on/off switch for 5-hydroxyconiferaldehyde O-methyltransferase activity in poplar monolignol biosynthesis
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 112(27), 8481–8486.
author keywords: AldOMT; COMT; lignin; phosphoproteomics; phosphoregulation
MeSH headings : Acrolein / analogs & derivatives; Acrolein / metabolism; Amino Acid Sequence; Binding Sites / genetics; Biocatalysis; Catechols / metabolism; Chromatography, Liquid; Electrophoresis, Polyacrylamide Gel; Green Fluorescent Proteins / genetics; Green Fluorescent Proteins / metabolism; Isoenzymes / genetics; Isoenzymes / metabolism; Lignin / biosynthesis; Methyltransferases / genetics; Methyltransferases / metabolism; Microscopy, Confocal; Molecular Sequence Data; Mutation; Phosphoproteins / metabolism; Phosphorylation; Plant Proteins / genetics; Plant Proteins / metabolism; Populus / enzymology; Populus / genetics; Populus / metabolism; Proteomics / methods; Protoplasts / enzymology; Protoplasts / metabolism; Sequence Homology, Amino Acid; Tandem Mass Spectrometry
TL;DR:
It is shown that reversible monophosphorylation at Ser123 or Ser125 acts as an on/off switch for the activity of 5-hydroxyconiferaldehyde O-methyltransferase 2 (PtrAldOMT2), an enzyme central to monolignol biosynthesis for lignification in stem-differentiating xylem of Populus trichocarpa.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Cardiac regenerative potential of cardiosphere-derived cells from adult dog hearts
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 19(8), 1805–1813.
author keywords: cardiosphere-derived cells; dogs; dilated cardiomyopathy; stem cell therapy
MeSH headings : Aging; Animals; Apoptosis; Cell Differentiation; Cells, Cultured; Dogs; Female; Fibrosis; Heart / physiology; Heart Function Tests; Mice, SCID; Myocardium / pathology; Myocytes, Cardiac / cytology; Neovascularization, Physiologic; Paracrine Communication; Regeneration; Spheroids, Cellular / cytology
TL;DR:
It is shown that canine CDCs can be produced from adult dog hearts and display similar phenotypes in comparison to previously studied CDCs derived from rodents and human beings.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2015 review
IRE mRNA riboregulators use metabolic iron (Fe2+) to control mRNA activity and iron chemistry in animals
[Review of ]. METALLOMICS, 7(1), 15–24.
MeSH headings : Animals; Ferritins / chemistry; Ferritins / genetics; Ferritins / metabolism; Humans; Iron / chemistry; Iron / metabolism; Iron-Regulatory Proteins / chemistry; Iron-Regulatory Proteins / genetics; Iron-Regulatory Proteins / metabolism; RNA, Messenger / chemistry; RNA, Messenger / genetics; RNA, Messenger / metabolism
TL;DR:
The high conservation of the primary sequence in IRE-mRNA control elements has facilitated their identification and analysis of metal-assisted riboregulator function, and expansion of RNA search analyses beyond primary will likely reveal other, metal-dependent families of mRNA riboreGulators.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 article
Assessing Intermolecular RNA:RNA Interactions Within a Ribonucleoprotein Complex Using Heavy Metal Cleavage Mapping
RNA-RNA INTERACTIONS: METHODS AND PROTOCOLS, Vol. 1240, pp. 125–134.
author keywords: Intermolecular RNA:RNA base pairing; Lead cleavage mapping; RNP assembly; Gel electrophoresis; Non-coding RNA
MeSH headings : Base Pairing; Base Sequence; Lead / metabolism; Molecular Biology / methods; Molecular Sequence Data; Multiprotein Complexes / metabolism; Nucleic Acid Denaturation; RNA / genetics; RNA / metabolism; Ribonucleoproteins / metabolism; Saccharomyces cerevisiae / metabolism; Sequence Analysis, RNA
TL;DR:
This chapter details how heavy metal cleavage mapping analysis was used to map the intermolecular RNA:RNA base pairing of a box C/D RNA with its target RNA within the assembling archaeal RNP complex.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 article
Populus trichocarpa
AGROBACTERIUM PROTOCOLS, VOLUME 2, THIRD EDITION, Vol. 1224, pp. 357–363.
author keywords: Agrobacterium tumefaciens; Genetic transformation; Populus trichocarpa; Transgenic trees
MeSH headings : Agrobacterium tumefaciens / genetics; Agrobacterium tumefaciens / growth & development; Coculture Techniques; Genetic Engineering / methods; Plant Roots / growth & development; Plant Shoots / growth & development; Populus / genetics; Populus / growth & development; Populus / physiology; Regeneration; Transformation, Genetic
TL;DR:
A modified step-by-step protocol for Agrobacterium-mediated transformation of stem explants is described here and the health of the tissue explants and the time of cocultivation are among the critical steps in the protocol for successful transformation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Interactions with the Bifunctional Interface of the Transcriptional Coactivator DCoH1 Are Kinetically Regulated
JOURNAL OF BIOLOGICAL CHEMISTRY, 290(7), 4319–4329.
MeSH headings : Animals; Chromatography, Gel; Crystallography, X-Ray; Hydro-Lyases / chemistry; Hydro-Lyases / genetics; Hydro-Lyases / metabolism; Kinetics; Mice; Models, Molecular; Mutation / genetics; Protein Conformation; Protein Folding; Protein Multimerization; Serine / chemistry; Serine / genetics; Serine / metabolism; Threonine / chemistry; Threonine / genetics; Threonine / metabolism; Water / chemistry
TL;DR:
It is shown that the DCoH1 homotetramer is kinetically trapped, meaning once it forms it will not dissociate to interact with HNF-1, and that the DCoH1·H NF-1 complex must co-fold to interact.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
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