Works Published in 2017
Displaying works 21 - 40 of 44 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2017 journal article
A comparison of sequencing platforms and bioinformatics pipelines for compositional analysis of the gut microbiome
BMC MICROBIOLOGY, 17.
author keywords: 16S rRNA amplicon sequencing; microbiome analysis; microbiome; microbiome composition; next generation sequencing platforms; Bioinformatics pipeline; NGS bias
MeSH headings : Analysis of Variance; Animals; Bacteria / classification; Bacteria / genetics; Base Sequence; Biodiversity; Cecum / microbiology; Chickens / microbiology; Computational Biology / instrumentation; Computational Biology / methods; DNA, Bacterial / analysis; DNA, Bacterial / genetics; DNA, Bacterial / isolation & purification; Gastrointestinal Microbiome / genetics; Gene Library; High-Throughput Nucleotide Sequencing / instrumentation; High-Throughput Nucleotide Sequencing / methods; Microbial Consortia / genetics; Multivariate Analysis; Phylogeny; RNA, Ribosomal, 16S / genetics; Reproducibility of Results; Statistics as Topic
TL;DR:
Overall microbiome compositional profiles were comparable between platforms; however, average relative abundance of specific taxa varied depending on sequencing platform, library preparation method, and bioinformatics analysis.
(via Semantic Scholar)
bmcmicrobiol.biomedcentral.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2017 journal article
A VIGS screen identifies immunity in the Arabidopsis Pla-1 accession to viruses in two different genera of the Geminiviridae
PLANT JOURNAL, 92(5), 796–807.
author keywords: Arabidopsis; BCTV; CaLCuV; geminivirus; gip-1; immunity; Pla-1; VIGS
MeSH headings : Arabidopsis / virology; Geminiviridae / immunology; Gene Silencing; Plant Diseases / immunology; Plant Diseases / virology; Plant Immunity; Quantitative Trait Loci / genetics
TL;DR:
The recessive nature of resistance to CaLCuV and the lack of obvious candidate genes near the gip‐1 locus suggest that a novel resistance gene(s) confers immunity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2017 journal article
Repliscan: a tool for classifying replication timing regions
BMC BIOINFORMATICS, 18, 1–14.
author keywords: DNA replication; Repli-seq; Classification
MeSH headings : DNA Replication Timing; Genome; Genome Size; High-Throughput Nucleotide Sequencing / methods; Sequence Analysis, DNA / methods; Software
TL;DR:
To accurately detect and classify regions of replication across the genome, Repliscan is presented, which robustly normalizes, automatically removes outlying and uninformative data points, and classifies Repli-seq signals into discrete combinations of replication signatures.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2017 journal article
Thermodynamic and Kinetic Analyses of Iron Response Element (IRE)-mRNA Binding to Iron Regulatory Protein, IRP1
SCIENTIFIC REPORTS, 7.
MeSH headings : Aconitate Hydratase / genetics; Animals; Cations, Divalent / metabolism; Ferritins / genetics; Iron / metabolism; Iron Regulatory Protein 1 / metabolism; Kinetics; Manganese / metabolism; Protein Binding; RNA, Messenger / metabolism; Rabbits; Response Elements; Temperature
TL;DR:
The observations suggest decreased RNA hydrogen bonding and changed RNA conformation upon IRP1 binding and illustrate how small, conserved, sequence differences among IRE-mRNAs selectively influence thermodynamic and kinetic selectivity of the protein/RNA interactions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Structural studies of Neurospora crassa LPMO9D and redox partner CDHIIA using neutron crystallography and small-angle scattering
CARBOHYDRATE RESEARCH, 448, 200–204.
author keywords: Polysaccharide monooxygenases; Cellobiose dehydrogenases; Neutron diffraction; Neutron scattering; X-ray induced photoreduction
MeSH headings : Carbohydrate Dehydrogenases / chemistry; Carbohydrate Dehydrogenases / metabolism; Catalytic Domain; Crystallography, X-Ray; Mixed Function Oxygenases / chemistry; Mixed Function Oxygenases / metabolism; Models, Molecular; Neurospora crassa / enzymology; Oxidation-Reduction; Scattering, Small Angle
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
7. Affordable and Clean Energy
(Web of Science)
12. Responsible Consumption and Production
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2017 journal article
Derivation of therapeutic lung spheroid cells from minimally invasive transbronchial pulmonary biopsies
RESPIRATORY RESEARCH, 18.
author keywords: Pulmonary progenitor cells; Lung spheroid; Stem cell
MeSH headings : Adolescent; Aged; Animals; Biopsy; Bronchi / cytology; Bronchi / physiology; Cell Culture Techniques / methods; Female; Human Umbilical Vein Endothelial Cells / physiology; Humans; Infusions, Intravenous; Lung / cytology; Lung / physiology; Male; Mice; Mice, Nude; Middle Aged; Spheroids, Cellular / physiology; Stem Cell Transplantation / methods; Stem Cells / physiology
TL;DR:
These cells could be utilized in long-term expansion of lung progenitor cells and as part of the development of cell-based therapies for the treatment of lung diseases such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Intracoronary allogeneic cardiosphere-derived stem cells are safe for use in dogs with dilated cardiomyopathy
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 21(8), 1503–1512.
author keywords: cardiosphere-derived cells; dogs; dilated cardiomyopathy; stem cell therapy; allogeneic
MeSH headings : Animals; Biomarkers / metabolism; Cardiomyopathy, Dilated / diagnostic imaging; Cardiomyopathy, Dilated / immunology; Cardiomyopathy, Dilated / pathology; Cardiomyopathy, Dilated / therapy; Coronary Vessels / cytology; Coronary Vessels / immunology; Dogs; Echocardiography; Endoglin / genetics; Endoglin / immunology; Female; Gene Expression; Humans; Male; Myocardium / immunology; Myocardium / pathology; Proto-Oncogene Proteins c-kit / genetics; Proto-Oncogene Proteins c-kit / immunology; Spheroids, Cellular / cytology; Spheroids, Cellular / immunology; Spheroids, Cellular / transplantation; Stem Cell Transplantation; Stem Cells / cytology; Stem Cells / immunology; Thy-1 Antigens / genetics; Thy-1 Antigens / immunology; Transplantation, Homologous
TL;DR:
The safety and efficacy of allogeneic CDC in a large animal (canine) model of spontaneous DCM and Histology on dog hearts revealed no sign of immune rejection from the transplanted cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Evaluation of physical and chemical properties and their interactions in fat, oil, and grease (FOG) deposits
WATER RESEARCH, 123, 173–182.
author keywords: Fat oil and grease; FOG; Grease; Blockages; Fatty acids; Physical properties; Chemical properties
MeSH headings : Fats / chemistry; Fatty Acids; Hydrocarbons; Metals; Sewage
TL;DR:
A thorough laboratory study was undertaken to examine key variables that contribute to FOG deposit formation under controlled conditions and it was found that FOG deposits can be created through fatty acid crystallization and not just saponification.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
12. Responsible Consumption and Production
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
A Regenerative Cardiac Patch Formed by Spray Painting of Biomaterials onto the Heart
TISSUE ENGINEERING PART C-METHODS, 23(3), 146–155.
author keywords: cardiac patch; platelet fibrin gel; myocardial infarction; regeneration
MeSH headings : Animals; Biocompatible Materials / chemistry; Blood Platelets / metabolism; Fibrin / metabolism; Heart / physiology; Male; Mice; Myocardial Infarction / pathology; Myocardial Infarction / therapy; Myocytes, Cardiac / cytology; Paintings; Rats; Rats, Sprague-Dawley; Regeneration / physiology
TL;DR:
The use of the spraying system allowed for placement of a uniform cardiac patch on the heart in a mini-invasive manner without the need for sutures or glue, and promoted cardiac repair and attenuated cardiac dysfunction after MI.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Modeling the Growth of Archaeon Halobacterium halobium Affected by Temperature and Light
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 181(3), 1080–1095.
author keywords: Halobacterium holobium; Sigmoidal model; Temperature effect; Light intensity effect; Bacteriorhodopsin
MeSH headings : Halobacterium salinarum / growth & development; Hot Temperature; Light; Models, Biological
TL;DR:
The Gompertz model was considered the best among the models studied to describe the growth of H. halobium affected by temperature or light.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2017 journal article
Malignant canine mammary tumours: Preliminary genomic insights using oligonucleotide array comparative genomic hybridisation analysis
VETERINARY JOURNAL, 222, 68–71.
author keywords: Array comparative genomic hybridisation; Canine mammary tumours; Chromosome; Genetics
MeSH headings : Animals; Comparative Genomic Hybridization / veterinary; DNA Copy Number Variations; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Female; Mammary Neoplasms, Animal / genetics; Mammary Neoplasms, Animal / pathology
TL;DR:
High resolution oligonucleotide array comparative genomic hybridisation was performed to assess genome wide DNA copy number changes in 10 malignant canine mammary tumours from seven female dogs, including multiple tumours collected at one time from each of three female dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Crystallization of a fungal lytic polysaccharide monooxygenase expressed from glycoengineered Pichia pastoris for X-ray and neutron diffraction
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 73(2), 70–78.
author keywords: lytic polysaccharide monooxygenases; Pichia pastoris; glycoengineering; neutron proteincrystallography
MeSH headings : Amino Acid Sequence; Catalytic Domain; Cloning, Molecular; Crystallography; Fungal Polysaccharides / chemistry; Fungal Polysaccharides / metabolism; Fungal Proteins / chemistry; Fungal Proteins / genetics; Fungal Proteins / metabolism; Gene Expression; Genetic Engineering; Mixed Function Oxygenases / chemistry; Mixed Function Oxygenases / genetics; Mixed Function Oxygenases / metabolism; Models, Molecular; Neurospora crassa / chemistry; Neurospora crassa / enzymology; Neutron Diffraction; Pichia / enzymology; Pichia / genetics; Plasmids / chemistry; Plasmids / metabolism; Protein Binding; Protein Conformation, beta-Strand; Recombinant Proteins / chemistry; Recombinant Proteins / genetics; Recombinant Proteins / metabolism; Substrate Specificity; X-Ray Diffraction
TL;DR:
Diffraction resolution and crystal morphology were improved by expressing NcPMO-2 from a glycoengineered strain of P. pastoris and by the use of crystal seeding methods, respectively, which resulted in high-resolution X-ray diffraction data collection at 100 K and the production of a large Nc PMO- 2 crystal suitable for room-temperature neutron diffractionData collection to 2.12 Å resolution.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(Web of Science)
12. Responsible Consumption and Production
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2017 journal article
Autophosphorylation-based Calcium (Ca2(+)) Sensitivity Priming and Ca2(+)/Calmodulin Inhibition of Arabidopsis thaliana Ca2(+)-dependent Protein Kinase 28 (CPK28)
JOURNAL OF BIOLOGICAL CHEMISTRY, 292(10), 3988–4002.
MeSH headings : Amino Acid Sequence; Arabidopsis / drug effects; Arabidopsis / growth & development; Arabidopsis / metabolism; Arabidopsis Proteins / metabolism; Calcium / pharmacology; Calmodulin / pharmacology; Gene Expression Regulation, Plant / drug effects; Kinetics; Phosphorylation / drug effects; Protein Binding; Protein Conformation; Protein Interaction Domains and Motifs; Protein Kinases / chemistry; Protein Kinases / metabolism; Sequence Homology, Amino Acid
TL;DR:
In situ autophosphorylation of CPK28 was demonstrated to have enhanced kinase activity at physiological concentrations of Ca2+ compared with the dephosphorylated protein, suggesting that autoph phosphorylation functions to primeCPK28 forCa2+ activation and might also allow CPK 28 to remain active when Ca2- levels are low.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Feasibility and safety of lumbosacral epiduroscopy in the standing horse
EQUINE VETERINARY JOURNAL, 49(3), 322–328.
author keywords: horse; back pain; hindlimb lameness; spinal nerve; epiduroscopy; endoscopy
MeSH headings : Animals; Endoscopy / methods; Endoscopy / veterinary; Epidural Space / surgery; Female; Horse Diseases / surgery; Horses; Lumbosacral Region / surgery; Male
TL;DR:
Lumbosacral epiduroscopy can be performed safely in sedated standing horses and may become a valuable diagnostic tool in horses with caudal back or hindlimb pain of unknown origin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2017 journal article
Design, selection, and development of cyclic peptide ligands for human erythropoietin
JOURNAL OF CHROMATOGRAPHY A, 1500, 105–120.
author keywords: Erythropoietin; Cyclic peptide ligands; Ligand screening; Affinity chromatography; Affinity maturation; In-silico docking
MeSH headings : Amino Acid Sequence; Amino Acids / chemistry; Erythropoietin / chemistry; Humans; Kinetics; Ligands; Molecular Sequence Data; Peptides, Cyclic / chemistry; Peptides, Cyclic / isolation & purification; Protein Binding
TL;DR:
Mutagenesis studies performed on FSLLSH with natural and non-natural amino acid substitutions led to the identification of critical EPO-binding determinants, and the discovery of new peptide ligands that facilitate EPO recovery.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Tissue and cell-type co-expression networks of transcription factors and wood component genes in Populus trichocarpa
PLANTA, 245(5), 927–938.
author keywords: Wood formation; Transcriptome; Fiber cells; Vessel elements; Cell wall biosynthesis; Co-expression network
MeSH headings : Cell Wall / metabolism; Cellulose / metabolism; Cluster Analysis; Gene Expression Regulation, Plant; Lignin / metabolism; Molecular Sequence Annotation; Organ Specificity; Phloem / genetics; Phloem / growth & development; Plant Leaves / genetics; Plant Leaves / growth & development; Plant Proteins / genetics; Populus / genetics; Populus / growth & development; Sequence Analysis, RNA; Transcription Factors / genetics; Transcriptome; Wood / genetics; Wood / growth & development; Xylem / genetics; Xylem / growth & development
TL;DR:
The co-expression networks revealed here suggest a well-structured transcriptional homeostasis for cell wall component biosynthesis during wood formation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Quantitative Proteomic Analysis of Human Airway Cilia Identifies Previously Uncharacterized Proteins of High Abundance
JOURNAL OF PROTEOME RESEARCH, 16(4), 1579–1592.
author keywords: cilia; axoneme; mass spectrometry; proteomics; airway; dynein; tubulin; radial spoke
MeSH headings : Axoneme / genetics; Cilia / genetics; Dyneins / genetics; Dyneins / isolation & purification; Gene Expression Regulation; Humans; Proteins / genetics; Proteins / isolation & purification; Proteome / genetics; Proteomics; Tubulin / genetics; Tubulin / isolation & purification
TL;DR:
These studies have provided the first quantitative analysis of the ciliary proteome and have identified and characterized several previously unknown proteins as major constituents of human airway cilia.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Differential CLE peptide perception by plant receptors implicated from structural and functional analyses of TDIF-TDR interactions
PLOS ONE, 12(4).
MeSH headings : Amino Acid Sequence; Arabidopsis Proteins / chemistry; Arabidopsis Proteins / metabolism; Binding Sites; Molecular Structure; Protein Binding; Protein Kinases / metabolism; Sequence Homology, Amino Acid
TL;DR:
These studies will open different unknown avenues of TDR-TDIF signaling pathways that will enhance knowledge in this field highlighting the receptor ligand interaction, receptor activation, signaling network, modes of action and will serve as a structure function relationship model between the ligand and the receptor for various similar leucine-rich repeat receptor-like kinases (LRR-RLKs).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Plant Stress Tolerance Requires Auxin-Sensitive Aux/IAA Transcriptional Repressors
CURRENT BIOLOGY, 27(3), 437–444.
MeSH headings : Arabidopsis / genetics; Arabidopsis / growth & development; Arabidopsis / physiology; Arabidopsis Proteins / antagonists & inhibitors; Arabidopsis Proteins / genetics; Arabidopsis Proteins / metabolism; Gene Expression Regulation, Plant / drug effects; Indoleacetic Acids / metabolism; Plant Growth Regulators / metabolism; Plants, Genetically Modified; Repressor Proteins / genetics; Repressor Proteins / metabolism; Stress, Physiological
TL;DR:
It is hypothesized that transcriptional control of Aux/IAA genes plays a central role in the establishment of the auxin-signaling pathways that regulate organogenesis, growth, and environmental response, and it is demonstrated that stress pathways interact with the auxIn gene regulatory network (GRN) through transcription of the Aux/ IAA genes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2017 journal article
Therapeutic microparticles functionalized with biomimetic cardiac stem cell membranes and secretome
NATURE COMMUNICATIONS, 8.
MeSH headings : Animals; Biomimetic Materials / chemistry; Biomimetic Materials / metabolism; Biomimetic Materials / pharmacology; Cell Fractionation; Cell Membrane / chemistry; Cell Membrane / metabolism; Cell Membrane / transplantation; Cell-Derived Microparticles / chemistry; Cell-Derived Microparticles / metabolism; Cell-Derived Microparticles / transplantation; Culture Media, Conditioned / chemistry; Culture Media, Conditioned / isolation & purification; Disease Models, Animal; Gene Expression; Hepatocyte Growth Factor / genetics; Hepatocyte Growth Factor / metabolism; Humans; Injections, Intralesional; Insulin-Like Growth Factor I / genetics; Insulin-Like Growth Factor I / metabolism; Intercellular Signaling Peptides and Proteins / pharmacology; Male; Mice; Myocardial Infarction / metabolism; Myocardial Infarction / pathology; Myocardial Infarction / therapy; Myocardium / metabolism; Myocardium / pathology; Paracrine Communication; Recovery of Function / drug effects; Stem Cells / cytology; Stem Cells / metabolism; Vascular Endothelial Growth Factor A / genetics; Vascular Endothelial Growth Factor A / metabolism
TL;DR:
A synthetic cell-mimicking microparticle that recapitulates stem cell functions in tissue repair and acts as ‘synthetic stem cells’ which mimic the paracrine and biointerfacing activities of natural stem cells in therapeutic cardiac regeneration.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
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