Works Published in 2021
Displaying works 21 - 40 of 41 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2021 journal article
Binding specificity and function of the SWI/SNF subunit SMARCA4 bromodomain interaction with acetylated histone
JOURNAL OF BIOLOGICAL CHEMISTRY, 297(4).
MeSH headings : Acetylation; Animals; Caenorhabditis elegans / genetics; Caenorhabditis elegans / metabolism; Caenorhabditis elegans Proteins / genetics; Caenorhabditis elegans Proteins / metabolism; Histones / genetics; Histones / metabolism; Humans; Protein Binding; Transcription Factors / genetics; Transcription Factors / metabolism
TL;DR:
An essential function for the SWI/SNF bromodomain in vivo is demonstrated and potential redundancy in epigenetic readers in regulating chromatin remodeling is detected and have implications for the development of small-molecule BD inhibitors to treat cancers and other diseases.
(via Semantic Scholar)
www.jbc.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science
Added: August 31, 2021
2021 journal article
A new inhibition mechanism in the multifunctional catalytic hemoglobin dehaloperoxidase as revealed by the DHP A(V59W) mutant: A spectroscopic and crystallographic study
JOURNAL OF PORPHYRINS AND PHTHALOCYANINES, 25(7-8), 756–771.
author keywords: Peroxidase; hemoglobin; structure-function; tryptophan; inhibition
TL;DR:
The data reveal a new mechanism of DHP inhibition, namely a shift towards a non-reactive form by OH that is strongly stabilized (presumably through H-bonding interactions) by the presence of W59 in the distal cavity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 23, 2021
2021 journal article
Population diversity of cassava mosaic begomoviruses increases over the course of serial vegetative propagation
JOURNAL OF GENERAL VIROLOGY, 102(7).
author keywords: cassava mosaic begomoviruses; vegetative propagation; viral diversity
MeSH headings : Base Sequence; Begomovirus / genetics; Begomovirus / physiology; Codon; DNA, Intergenic; DNA, Viral / genetics; Evolution, Molecular; Genetic Variation; Genome, Viral; Manihot / growth & development; Manihot / virology; Mutation; Plant Diseases / virology; Polymorphism, Single Nucleotide; Satellite Viruses / genetics; Satellite Viruses / physiology; Sequence Deletion; Temperature; Viral Proteins / genetics
TL;DR:
It is found that vegetative propagation had a significant effect on viral nucleotide diversity, while temperature and a satellite DNA did not have measurable impacts in this study.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 16, 2021
2021 journal article
Synthesis, biochemical, and biological evaluation of C2 linkage derivatives of amino sugars, inhibitors of glucokinase from Trypanosoma cruzi
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 47.
author keywords: Chagas' disease; Neglected tropical diseases; Glucokinase; Amino sugars; Inhibitors
MeSH headings : Amino Sugars / chemical synthesis; Amino Sugars / chemistry; Amino Sugars / pharmacology; Dose-Response Relationship, Drug; Enzyme Inhibitors / chemical synthesis; Enzyme Inhibitors / chemistry; Enzyme Inhibitors / pharmacology; Glucokinase / antagonists & inhibitors; Glucokinase / metabolism; Molecular Structure; Structure-Activity Relationship; Trypanosoma cruzi / enzymology
TL;DR:
Eighteen amino sugar analogues were synthesized and screened against Trypanosoma cruzi glucokinase (TcGlcK), a potential drug-target of the protozoan parasite in order to assess for viable enzyme inhibition.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 16, 2021
2021 journal article
BEL1-like Homeodomain Protein BLH6a Is a Negative Regulator of CAl5H2 in Sinapyl Alcohol Monolignol Biosynthesis in Poplar
FRONTIERS IN PLANT SCIENCE, 12.
author keywords: lignin; BEL1-like homeodomain protein; transcription factor; yeast one hybrid
TL;DR:
It is proposed that BLH6a is a negative regulator of CAld5H2, which acts through combinatorial regulation of multiple TFs for sinapyl alcohol (S monolignol) biosynthesis in poplar.
(via Semantic Scholar)
Source: Web Of Science
Added: July 19, 2021
2021 article
Hi-C scaffolded short- and long-read genome assemblies of the California sea lion are broadly consistent for syntenic inference across 45 million years of evolution
Peart, C. R., Williams, C., Pophaly, S. D., Neely, B. A., Gulland, F. M. D., Adams, D. J., … Wolf, J. B. W. (2021, June 27). MOLECULAR ECOLOGY RESOURCES.
author keywords: California sea lion (Zalophus californianus); cancer; Carnivora; chromatin interaction mapping; genome assembly; genome evolution; Hi-C
MeSH headings : Animals; Dogs; Ferrets; Genome; Sea Lions / genetics; Synteny; X Chromosome
TL;DR:
This study presents high-quality genomes of an emerging cancer model and highlights that even highly fragmented short-read assemblies scaffolded with Hi-C can yield reliable chromosome level scaffolds suitable for comparative genomic analyses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: July 6, 2021
2021 journal article
Warm nights disrupt transcriptome rhythms in field-grown rice panicles
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 118(25).
author keywords: climate change impact; nighttime temperature increase; global food security; diel transcriptional networks
MeSH headings : Agriculture; Biomass; Circadian Rhythm / genetics; Gene Expression Profiling; Gene Expression Regulation, Plant; Gene Regulatory Networks; Genes, Plant; Oryza / genetics; Oryza / growth & development; RNA, Messenger / genetics; RNA, Messenger / metabolism; Reproducibility of Results; Temperature; Time Factors; Transcription Factors / metabolism; Transcription, Genetic; Transcriptome / genetics
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: June 22, 2021
2021 review
MYB-Mediated Regulation of Anthocyanin Biosynthesis
[Review of ]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(6).
author keywords: MYB; transcription factor; anthocyanin; positive regulation; negative regulation; environment; MBW complexes
MeSH headings : Anthocyanins / biosynthesis; Gene Expression Regulation, Plant; Gene Regulatory Networks; Phylogeny; Plant Proteins / chemistry; Plant Proteins / metabolism; Transcription Factors / chemistry; Transcription Factors / metabolism
TL;DR:
Some prospects for MYB-TF to modulate the comprehensive regulation of anthocyanins are put forward to provide a more relevant basis for further research in this field, and to guide the directed genetic modification of anthcyanins for the improvement of crops for food quality, nutrition and human health.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: May 24, 2021
2021 journal article
SnRK1: a versatile plant protein kinase that limits geminivirus infection
CURRENT OPINION IN VIROLOGY, 47, 18–24.
MeSH headings : Disease Resistance; Geminiviridae / genetics; Geminiviridae / metabolism; Geminiviridae / physiology; Host-Pathogen Interactions; Phosphorylation; Plant Diseases / virology; Plant Proteins / genetics; Plant Proteins / metabolism; Protein Kinases / genetics; Protein Kinases / metabolism; Viral Proteins / genetics; Viral Proteins / metabolism
TL;DR:
Data suggest that SnRK1 is involved in the co-evolution of plant hosts and geminiviruses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: May 17, 2021
2021 journal article
Loss of Small-RNA-Directed DNA Methylation in the Plant Cell Cycle Promotes Germline Reprogramming and Somaclonal Variation
CURRENT BIOLOGY, 31(3), 591-+.
MeSH headings : Arabidopsis / genetics; Arabidopsis / metabolism; Cell Cycle; Cytosine; DNA Methylation; DNA, Plant; Gene Expression Regulation, Plant; Germ Cells / metabolism; Histones / genetics; Histones / metabolism; Plants / metabolism; RNA, Small Interfering / genetics
TL;DR:
Comparative analysis with methylomes of various tissues and cell types suggests that loss of small-RNA-directed non-CG methylation during DNA replication promotes germline reprogramming and epigenetic variation in plants propagated as clones.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: April 12, 2021
2021 journal article
Remodeling hydrogen bond Interactions results in relaxed specificity of Caspase-3
BIOSCIENCE REPORTS, 41(1).
MeSH headings : Amino Acid Sequence; Animals; Aspartic Acid / metabolism; Caspase 3 / chemistry; Caspase 3 / metabolism; Caspase 6 / metabolism; Humans; Hydrogen Bonding; Sequence Homology, Amino Acid; Substrate Specificity; Valine / metabolism; Zebrafish; Zebrafish Proteins / chemistry; Zebrafish Proteins / metabolism
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: April 12, 2021
2021 journal article
Preliminary results of neutron and X-ray diffraction data collection on a lytic polysaccharide monooxygenase under reduced and acidic conditions
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 77(4), 128–133.
author keywords: lytic polysaccharide monooxygenases; Neurospora crassa; neutron protein crystallography; reduction; protonation; enzymatic mechanism.
MeSH headings : Data Collection / methods; Hydrogen-Ion Concentration; Mixed Function Oxygenases / analysis; Mixed Function Oxygenases / chemistry; Neurospora crassa / chemistry; Neutron Diffraction / methods; Polysaccharides / analysis; Polysaccharides / chemistry; Protein Structure, Secondary; X-Ray Diffraction / methods
TL;DR:
To characterize the reaction-mechanism intermediates of LPMO9D from Neurospora crassa, a cryo-neutron diffraction data set was collected from an ascorbate-reduced crystal to probe the protonation states of ionizable groups involved in catalysis under acidic conditions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(Web of Science)
12. Responsible Consumption and Production
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 1, 2021
2021 journal article
Quantification of gray mold infection in lettuce using a bispectral imaging system under laboratory conditions
PLANT DIRECT, 5(3).
author keywords: disease detection; gray mold; hyperspectral imaging; multispectral imaging; plant pathology; reflectance indexing
TL;DR:
This paper design and build a bispectral imaging system for discriminating between leaf regions infected with gray mold and those that remain unharmed on a lettuce (Lactuca spp.) host using two optimal spectral bands from continuous hyperspectral imagery.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: March 25, 2021
2021 journal article
Genome-wide association study and gene network analyses reveal potential candidate genes for high night temperature tolerance in rice
SCIENTIFIC REPORTS, 11(1).
MeSH headings : Computational Biology / methods; Edible Grain / genetics; Gene Expression Profiling; Gene Expression Regulation, Plant; Gene Regulatory Networks; Genetic Association Studies; Genome-Wide Association Study / methods; Oryza / genetics; Phenotype; Stress, Physiological; Temperature
TL;DR:
Integrated physiological, genomic, and gene network-informed approaches indicate that the candidate genes for stay-green trait may be relevant to minimizing HNT-induced yield and quality losses during grain filling in rice by optimizing source-sink relationships.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: March 25, 2021
2021 journal article
Impact of Ceftiofur Administration in Steers on the Prevalence and Antimicrobial Resistance of Campylobacter spp.
MICROORGANISMS, 9(2).
author keywords: ceftiofur; CCFA; CHCL; cattle; Campylobacter; antibiotic resistance
TL;DR:
It is suggested that CCFA or CHCL may be preferable due to the lower likelihood of temporary increases in Campylobacter prevalence and ceftiofur minimum inhibitory concentration (MIC) for C. jejuni, respectively.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: March 15, 2021
2021 article
Cultural Entanglements: Langston Hughes and the Rise of African and Caribbean Literature
Miller, W. J. (2021, February 1). MODERN PHILOLOGY, Vol. 118, pp. E224–E226.
UN Sustainable Development Goal Categories
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: February 22, 2021
2021 journal article
Structure, Function, and Thermal Adaptation of the Biotin Carboxylase Domain Dimer from Hydrogenobacter thermophilus 2-Oxoglutarate Carboxylase
BIOCHEMISTRY, 60(4), 324–345.
MeSH headings : Bacteria / enzymology; Bacterial Proteins / chemistry; Carbon-Nitrogen Ligases / chemistry; Crystallography, X-Ray; Enzyme Stability; Hot Temperature; Protein Domains; Structure-Activity Relationship
TL;DR:
Structural data reveal that the OGC BC dimer comprises a "wet" dimerization interface that is dominated by hydrophilic interactions and structural water molecules common to all BC domains and likely facilitates the conformational changes associated with the catalytic cycle.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: January 20, 2021
2021 journal article
Qu-2, a robust poplar suspension cell line for molecular biology
JOURNAL OF FORESTRY RESEARCH, 32(2), 733–740.
author keywords: Qu-2 cell line; Suspension cell; Poplar; Protoplast isolation; Transient transformation
TL;DR:
A hormone autotrophic poplar suspension cell line from a hybrid of Populus alba × P. berolinensis ‘Yinzhong’, named Qu-2, which has the great potential to be an excellent model cell line in tree molecular biological research, ranging from physiology to gene function.
(via Semantic Scholar)
Source: Web Of Science
Added: January 4, 2021
2021 journal article
A protocol for genome-wide analysis of DNA replication timing in intact root tips
Methods in Molecular Biology Series.
Source: NC State University Libraries
Added: December 18, 2020
2021 review
Integration of Sugar Metabolism and Proteoglycan Synthesis by UDP-glucose Dehydrogenase
[Review of ]. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 69(1), 13–23.
author keywords: developmental disorders; extracellular matrix; glucuronidation; glycosaminoglycan; hyaluronan; nucleotide sugars; post-translational modifications; proteoglycan; UDP-glucuronate
MeSH headings : Allosteric Regulation; Animals; Biosynthetic Pathways; Humans; Models, Molecular; Neoplasms / metabolism; Protein Processing, Post-Translational; Proteoglycans / metabolism; Sugars / metabolism; Uridine Diphosphate Glucose Dehydrogenase / chemistry; Uridine Diphosphate Glucose Dehydrogenase / metabolism
TL;DR:
The cellular mechanisms that regulate UG DH expression are reviewed, the structural features of the enzyme are discussed, and the structures are used to provide a context for recent studies that link post-translational modifications and allosteric modulators of UGDH to its function in downstream pathways.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 24, 2020
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