Works Published in 2010
Displaying works 1 - 20 of 41 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2010 journal article
Growth and Maintenance of Mosquito Cell Lines
Current Protocols in Microbiology, 17(1), A.4J.1-A.4J.8.
MeSH headings : Animals; Cell Culture Techniques / methods; Cell Line; Culicidae; Culture Media / chemistry
TL;DR:
Mosquito cells (Aedes albopictus) are among the most common insect cells emerging as new sources of cell cultures to use in basic research and in the pharmaceutical industry.
(via Semantic Scholar)
Source: Crossref
Added: October 9, 2021
2010 journal article
Growth and Maintenance of Chick Embryo Fibroblasts (CEF)
Current Protocols in Microbiology, 17(1), A.4I.1-A.4I.8.
MeSH headings : Animals; Cell Culture Techniques; Cells, Cultured; Chick Embryo; Culture Media / chemistry; Fibroblasts
TL;DR:
Primary cultures of chick embryo fibroblasts are widely used for the cultivation of viruses and Protocols for the growth and maintenance of CEF cells in the laboratory are provided.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: Crossref
Added: August 16, 2021
2010 journal article
Growth and Maintenance of Baby Hamster Kidney (BHK) Cells
Current Protocols in Microbiology, 17(1), A.4H.1-A.4H.7.
MeSH headings : Animals; Cell Culture Techniques; Cell Line; Cricetinae; Culture Media / chemistry; Fibroblasts; Kidney / cytology; Mesocricetus; Sindbis Virus / growth & development; Virus Cultivation / methods
TL;DR:
The BHK21 cell line was established in 1961 from the kidneys of 5 Syrian hamsters from litter number 21 and has been a laboratory standard for the growth of countless viruses and the study of many biological processes.
(via Semantic Scholar)
Source: Crossref
Added: August 14, 2021
2010 journal article
Circadian control of global gene expression patterns.
Annual Review of Genetics.
author keywords: transcriptome; network analysis; transcriptional regulation; microarray analysis; systems biology
MeSH headings : Animals; Arabidopsis / genetics; Arabidopsis / physiology; Circadian Clocks; Circadian Rhythm; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Gene Expression Regulation; Humans; Mice
TL;DR:
The impacts transcriptomics have had on the understanding of the clock and how this molecular clock connects with system-level circadian responses are reviewed and the discoveries made possible by high-throughput RNA assays, the network approaches used to investigate these large transcript datasets, and potential future directions are explored.
(via Semantic Scholar)
europepmc.org (repository)
Source: ORCID
Added: January 25, 2021
2010 journal article
Structural Basis for Feedback and Pharmacological Inhibition of Saccharomyces cerevisiae Glutamate Cysteine Ligase
Journal of Biological Chemistry, 285(19), 14459–14466.
MeSH headings : Adenosine Triphosphate / metabolism; Binding Sites; Buthionine Sulfoximine / metabolism; Crystallization; Crystallography, X-Ray; Enzyme Inhibitors / metabolism; Glutamate-Cysteine Ligase / chemistry; Glutamate-Cysteine Ligase / genetics; Glutamate-Cysteine Ligase / metabolism; Glutathione / metabolism; Kinetics; Models, Chemical; Models, Molecular; Mutagenesis, Site-Directed; Mutation / genetics; Protein Conformation; Saccharomyces cerevisiae / enzymology; Saccharomyces cerevisiae / genetics
TL;DR:
The structures of two inhibited forms of Saccharomyces cerevisiae GCL are determined, which shares significant sequence identity with the human enzyme and provide additional details of the catalytic mechanism of the enzyme.
(via Semantic Scholar)
Source: Crossref
Added: October 29, 2020
2010 journal article
Synthesis, NMR characterization and divergent biological actions of 2 '-hydroxy-ceramide/dihydroceramide stereoisomers in MCF7 cells
BIOORGANIC & MEDICINAL CHEMISTRY, 18(21), 7565–7579.
author keywords: Ceramide; (2 ' R)-2 '-Hydroxy-ceramide; (2 ' S)-2 '-Hydroxy-ceramide; Stereospecificity; Synthesis; LC-MS/MS; NMR; Cytotoxicity; Cellular sphingolipids
MeSH headings : Cell Line, Tumor; Ceramides / chemical synthesis; Ceramides / chemistry; Ceramides / pharmacology; Humans; Magnetic Resonance Spectroscopy; Sphingolipids / metabolism; Stereoisomerism; Time Factors
TL;DR:
Stereoisomers of 2'-OHCers can be potentially utilized as novel molecular tools to study lipid-protein interactions, cell signaling phenomena and to understand the role of hydroxylated sphingolipids in cancer biology, pathogenesis and therapy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Long range dynamic effects of point-mutations trap a response regulator in an active conformation
FEBS LETTERS, 584(19), 4203–4207.
author keywords: NMR; Conformational transition; Intra-protein communication; Response regulator; Spo0F
MeSH headings : Bacillus subtilis / genetics; Bacillus subtilis / metabolism; Bacterial Proteins / chemistry; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Models, Molecular; Mutagenesis, Site-Directed; Mutant Proteins / chemistry; Mutant Proteins / genetics; Mutant Proteins / metabolism; Nuclear Magnetic Resonance, Biomolecular; Point Mutation; Principal Component Analysis; Protein Conformation; Second Messenger Systems / genetics; Signal Transduction / genetics; Thermodynamics
TL;DR:
It is shown that point‐mutations, distant from an essential highly dynamic kinase recognition loop in the response regulator Spo0F, lock this loop in an active conformation, which results in functionally hyperactive Spo0f.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Lignin and Biomass: A Negative Correlation for Wood Formation and Lignin Content in Trees
PLANT PHYSIOLOGY, 154(2), 555–561.
MeSH headings : Biomass; Gene Expression Regulation, Plant; Lignin / biosynthesis; Lignin / chemistry; Transcription Factors / metabolism; Trees / genetics; Trees / growth & development; Trees / metabolism; Wood / genetics; Wood / growth & development; Wood / metabolism
TL;DR:
Studies in populations of forest tree hybrids have shown a negative correlation of biomass growth and lignin content, implying that selection for biomass growth may be highly regulated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Kinetic Stability May Determine the Interaction Dynamics of the Bifunctional Protein DCoH1, the Dimerization Cofactor of the Transcription Factor HNF-1 alpha
BIOCHEMISTRY, 49(47), 10187–10197.
MeSH headings : Chromatography, Gel; Enzyme Stability; Guanidine / pharmacology; Hepatocyte Nuclear Factor 1-alpha / metabolism; Hydro-Lyases / genetics; Hydro-Lyases / metabolism; Kinetics; Models, Molecular; Point Mutation; Protein Denaturation; Protein Multimerization; Protein Unfolding; Spectrometry, Fluorescence; Tryptophan / chemistry
TL;DR:
This work shows that a point mutation at the DCoH1 tetramer interface, Thr 51 Ser, overcomes the dissociation barrier of the homotetramer and increases the interaction with HNF-1α, and proposes an unfolding pathway in which the tetramer unfolds slowly, but the dimer folds reversibly.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2010 journal article
Transcriptional regulation of ferritin and antioxidant genes by HIPK2 under genotoxic stress
JOURNAL OF CELL SCIENCE, 123(22), 3863–3871.
author keywords: HIPK2; ATF1; Phosphorylation; Ferritin; Genotoxic stress; Transcription
MeSH headings : Activating Transcription Factor 1 / genetics; Activating Transcription Factor 1 / metabolism; Carrier Proteins / genetics; Carrier Proteins / metabolism; Cell Growth Processes / genetics; Cell Survival / genetics; DNA Damage; Ferritins / genetics; Ferritins / metabolism; Gene Expression Regulation; Humans; Phosphorylation; Protein Serine-Threonine Kinases / genetics; Protein Serine-Threonine Kinases / metabolism; Transcription Factors / genetics; Transcription Factors / metabolism
TL;DR:
HIPK2 (homeodomain-interacting protein kinase 2), a DNA-damage-responsive nuclear kinase, is a new ATF1 kinase involved in the regulation of ferritin H and other antioxidant detoxification genes in genotoxic stress conditions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Crystallization and preliminary X-ray diffraction analysis of red clover necrotic mosaic virus
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 66(Pt 11), 1458–1462.
author keywords: red clover necrotic mosaic virus; dianthoviruses; viruses
MeSH headings : Crystallization; Crystallography, X-Ray; Microscopy, Electron, Transmission; Tombusviridae / chemistry; Tombusviridae / ultrastructure; Virion / chemistry; Virion / ultrastructure
TL;DR:
Red clover necrotic mosaic virus is a species that belongs to the Tombusviridae family of plant viruses with a T = 3 icosahedral capsid and crystals diffracted to better than 4 Å resolution but were very radiation-sensitive, causing rapid decay of the high-resolution reflections.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2010 journal article
Antiplasmodial and cytotoxic activities of drimane sesquiterpenes from Canella winterana
Natural Product Communications, 5(12), 1869–1872.
Source: NC State University Libraries
Added: August 6, 2018
2010 journal article
Specific down-regulation of PAL genes by artificial microRNAs in Populus trichocarpa
PLANTA, 232(6), 1281–1288.
author keywords: Artificial microRNA; Phenylalanine ammonia-lyase; Populus trichocarpa transformation; Down-regulation; PolyA tailing-based real time RT-PCR; Quantitation
MeSH headings : Base Sequence; DNA Primers; Down-Regulation; Genes, Plant; MicroRNAs / physiology; Mutation; Populus / genetics; Reverse Transcriptase Polymerase Chain Reaction; Sequence Homology, Nucleic Acid
TL;DR:
This paper describes the specific down-regulation of multiple genes in the phenylalanine ammonia-lyase (PAL) gene family of Populus trichocarpa using amiRNA sequences incorporated in a ptc-MIR408 miRNA-producing precursor, revealing differential regulation within the gene family.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
NMR Solution Structure and DNA-binding Model of the DNA-binding Domain of Competence Protein A
JOURNAL OF MOLECULAR BIOLOGY, 398(2), 248–263.
author keywords: competence; ComA; NMR; two-component; response regulator
MeSH headings : Amino Acid Sequence; Bacillus subtilis / metabolism; Bacterial Proteins / chemistry; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; DNA / chemistry; DNA / metabolism; DNA-Binding Proteins / chemistry; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Escherichia coli Proteins / chemistry; Escherichia coli Proteins / genetics; Escherichia coli Proteins / metabolism; Helix-Turn-Helix Motifs; Models, Molecular; Molecular Sequence Data; Nuclear Magnetic Resonance, Biomolecular; Protein Structure, Tertiary
TL;DR:
Using NMR spectroscopy, the high-resolution 3D solution structure of the C-terminal DNA-binding domain of ComA (ComAC) has been determined and a model of ComAC bound to the ComA recognition sequences on the srfA promoter has been developed, suggesting a basis for DNA binding specificity within the NarL family.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Arabidopsis thaliana as a model for gelatinous fiber formation
RUSSIAN JOURNAL OF PLANT PHYSIOLOGY, 57(3), 363–367.
author keywords: Arabidpsis thaliana; cambium; gelatinous fibers; gravity; reaction wood; tension wood
TL;DR:
Repeated clipping of the emerging inflorescence stems of Arabidopsis thaliana augments wood formation in organs, including those inflorescent stems that are allowed to develop later, allowing the use of A.Thaliana for a molecular and genetic analysis of the mechanisms of tension wood formation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
The Structure of Sindbis Virus Produced from Vertebrate and Invertebrate Hosts as Determined by Small-Angle Neutron Scattering
JOURNAL OF VIROLOGY, 84(10), 5270–5276.
MeSH headings : Animals; Cell Line; Cricetinae; Culicidae; Scattering, Small Angle; Sindbis Virus / chemistry; Sindbis Virus / growth & development; Virion / chemistry; Virion / isolation & purification
TL;DR:
The first study of the structural differences between Sindbis viruses grown in mammalian and insect cells are reported, which were determined by small-angle neutron scattering (SANS), a nondestructive technique that did not decrease the infectivity of the Sindbis virus particles studied.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2010 journal article
Binding of aminoglycoside antibiotics to helix 69 of 23S rRNA
Nucleic Acids Research, 38(9), 3094–3105.
Source: NC State University Libraries
Added: August 6, 2018
2010 journal article
Role of Antioxidant Enzymes in Bacterial Resistance to Organic Acids
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 76(9), 2747–2753.
MeSH headings : Antioxidants / metabolism; Antioxidants / physiology; Bacterial Proteins / genetics; Escherichia coli / genetics; Escherichia coli / metabolism; Hydrogen-Ion Concentration; Iron / metabolism; Lactic Acid / toxicity; Oxidative Stress; Streptococcus thermophilus / drug effects; Streptococcus thermophilus / enzymology; Stress, Physiological; Superoxide Dismutase / genetics; Superoxide Dismutase / metabolism; Superoxide Dismutase / physiology
TL;DR:
It is suggested that acid stress triggers an iron-mediated oxidative stress that can be ameliorated by MnSOD and iron chelators and may explain the ability of some microorganisms to survive better in acidified environments, as in acid foods during fermentation and accumulation of lactic acid or during passage through the low pH of the stomach.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2010 journal article
Improving Protein and Proteome Coverage through Data-Independent Multiplexed Peptide Fragmentation
JOURNAL OF PROTEOME RESEARCH, 9(7), 3621–3637.
author keywords: Proteomics; mass spectrometry; protein characterization; data-independent acquisition (DIA); data-dependent acquisition (DDA); protein identification; LC/MSE
MeSH headings : Amino Acid Sequence; Animals; Arabidopsis Proteins / chemistry; Arabidopsis Proteins / metabolism; Artifacts; Cattle; Chromatography, Liquid / methods; Ions / chemistry; Solanum lycopersicum; Mass Spectrometry / methods; Molecular Sequence Data; Peptide Fragments / chemistry; Peptide Fragments / metabolism; Plant Leaves; Plant Proteins / chemistry; Plant Proteins / metabolism; Protein Kinases / chemistry; Protein Kinases / metabolism; Proteomics / methods; Serum Albumin, Bovine / chemistry; Serum Albumin, Bovine / metabolism; Trypsin / metabolism
TL;DR:
The fundamental limitations of serial MS/MS interrogation are revealed and the advantages of parallel fragmentation by DIA for more comprehensive protein identification and characterization are revealed which holds promise for enhanced isoform and post-translational modification analysis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Arabidopsis thaliana Chromosome 4 Replicates in Two Phases That Correlate with Chromatin State
PLoS Genetics, 6(6), e1000982.
Ed(s): G. Copenhaver
MeSH headings : Arabidopsis / cytology; Arabidopsis / genetics; Chromatin / genetics; Chromosomes, Plant; DNA Replication; Epigenesis, Genetic; Flow Cytometry; Oligonucleotide Array Sequence Analysis; Replicon; S Phase
TL;DR:
The similarity of the replication profiles for early and mid S phase cells indicates that replication origin activation in euchromatin is stochastic, and distinct patterns of association of H3K56ac with gene expression and early replication provide evidence that H3k56ac may be associated with initiation zones and replication origins.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
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