Works Published in 2011
Displaying works 1 - 20 of 40 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2011 journal article
A comparison of the low temperature transcriptomes and CBF regulons of three plant species that differ in freezing tolerance: Solanum commersonii, Solanum tuberosum, and Arabidopsis thaliana.
Journal of Experimental Botany.
author keywords: Arabidopsis; CBF regulon; freezing tolerance; low temperature transcriptome; Solanum species
MeSH headings : Acclimatization; Arabidopsis / genetics; Arabidopsis / metabolism; Arabidopsis / physiology; Arabidopsis Proteins / genetics; Arabidopsis Proteins / metabolism; Core Binding Factors / genetics; Core Binding Factors / metabolism; Freezing; Gene Expression Regulation, Plant; Plant Proteins / genetics; Plant Proteins / metabolism; Regulon; Solanum / genetics; Solanum / metabolism; Solanum / physiology; Solanum tuberosum / genetics; Solanum tuberosum / metabolism; Solanum tuberosum / physiology; Species Specificity; Transcription Factors / genetics; Transcription Factors / physiology; Transcription, Genetic / genetics
TL;DR:
It seems likely that these conserved cold-regulated genes—many of which encode transcription factors and proteins of unknown function—have fundamental roles in plant growth and development at low temperature.
(via Semantic Scholar)
europepmc.org (repository)
Source: ORCID
Added: January 25, 2021
2011 journal article
Enzymatic Defects Underlying Hereditary Glutamate Cysteine Ligase Deficiency Are Mitigated by Association of the Catalytic and Regulatory Subunits
Biochemistry, 50(29), 6508–6517.
MeSH headings : Animals; Catalytic Domain; Enzyme Stability; Glutamate-Cysteine Ligase / chemistry; Glutamate-Cysteine Ligase / deficiency; Glutamate-Cysteine Ligase / metabolism; Glutathione / biosynthesis; Homozygote; Humans; Kinetics; Mice; Models, Biological; Mutant Proteins / metabolism; Mutation / genetics; Protein Binding; Protein Structure, Secondary; Recombinant Proteins / metabolism; Saccharomyces cerevisiae / metabolism; Structural Homology, Protein; Temperature
TL;DR:
Kinetic characterizations of the recombinant GCLC mutants indicated that the Arg127Cys, His370Leu, and Pro414Leu mutants have compromised enzymatic activity that can largely be rescued by the addition of GCLM, suggesting that heterodimer formation is needed for stability in vivo.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2011 journal article
Mass Spectrometric Detection of Targeting Peptide Bioconjugation to Red clover necrotic mosaic virus
BIOCONJUGATE CHEMISTRY, 22(10), 1970–1982.
MeSH headings : Amino Acid Sequence; Capsid / chemistry; Cross-Linking Reagents / chemistry; Drug Delivery Systems; Mass Spectrometry; Models, Molecular; Molecular Sequence Data; Peptides / chemistry; Tombusviridae / chemistry
TL;DR:
Results show that heterobifunctional linkers may not be the most efficient method for attachment of peptides to plant virus capsids, and maleimide peptides were used to conjugate with the virus in a one-step reaction.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Intercepting Bacterial Indole Signaling with Flustramine Derivatives
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 133(50), 20160–20163.
MeSH headings : Escherichia coli / metabolism; Hydrocarbons, Brominated / metabolism; Indole Alkaloids / metabolism; Indoles / metabolism; Signal Transduction; Staphylococcus aureus / metabolism
TL;DR:
DFBr derivatives are found that are 10-1000 times more active than indole itself, demonstrating that the flustramine family of indolic natural products represent a privileged scaffold for the design of molecules to control pathogenic bacterial behavior.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Tomato SlSnRK1 Protein Interacts with and Phosphorylates beta C1, a Pathogenesis Protein Encoded by a Geminivirus beta-Satellite
PLANT PHYSIOLOGY, 157(3), 1394–1406.
MeSH headings : DNA, Viral / metabolism; Geminiviridae / metabolism; Geminiviridae / pathogenicity; Gene Expression Regulation, Plant; Solanum lycopersicum / enzymology; Solanum lycopersicum / genetics; Solanum lycopersicum / virology; Mutation / genetics; Phosphorylation; Phosphoserine / metabolism; Phosphothreonine / metabolism; Plant Diseases / virology; Plant Proteins / chemistry; Plant Proteins / genetics; Plant Proteins / metabolism; Protein Binding; Protein Interaction Domains and Motifs; Satellite Viruses / metabolism; Satellite Viruses / pathogenicity; Subcellular Fractions / metabolism; Viral Proteins / chemistry; Viral Proteins / metabolism
TL;DR:
Results suggested that the SlSnRK1 protein attenuates geminivirus infection by interacting with and phosphorylating the βC1 protein.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018
2011 journal article
The Fur regulon in anaerobically grown Salmonella enterica sv. Typhimurium: identification of new Fur targets
BMC MICROBIOLOGY, 11.
MeSH headings : Anaerobiosis; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Gene Expression Regulation, Bacterial; Iron / metabolism; Oxygen / metabolism; Regulon; Repressor Proteins / genetics; Repressor Proteins / metabolism; Salmonella typhimurium / genetics; Salmonella typhimurium / metabolism
TL;DR:
This work identified twenty-six new targets of Fur regulation, and demonstrates that H-NS repressed genes are down-regulated in Δfur, indicating that Fur is a positive factor in ftnB regulation, while serving to repress the expression of hmpA.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 article
New Dimensions of RNA in Molecular Recognition and Catalysis
Theil, E. C., & Westhof, E. (2011, December). ACCOUNTS OF CHEMICAL RESEARCH, Vol. 44, pp. 1255–1256.
MeSH headings : Catalysis; RNA / chemistry; RNA / metabolism; RNA, Catalytic / chemistry; RNA, Catalytic / metabolism; RNA, Untranslated / chemistry; RNA, Untranslated / metabolism
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Membrane protein complexes catalyze both 4-and 3-hydroxylation of cinnamic acid derivatives in monolignol biosynthesis
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108(52), 21253–21258.
MeSH headings : Carboxylic Ester Hydrolases / chemistry; Carboxylic Ester Hydrolases / metabolism; Chromatography, Liquid; Coumaric Acids; DNA Primers / genetics; Hydroxylation; Immunoprecipitation; Kinetics; Lignin / biosynthesis; Mass Spectrometry; Membrane Proteins / chemistry; Membrane Proteins / metabolism; Microscopy, Confocal; Molecular Structure; Multiprotein Complexes / chemistry; Multiprotein Complexes / metabolism; Phenols; Phenylpropionates; Plasmids / genetics; Populus / metabolism; Propionates; Trans-Cinnamate 4-Monooxygenase / chemistry; Trans-Cinnamate 4-Monooxygenase / metabolism; Xylem / metabolism; Yeasts
TL;DR:
Affinity purification-quantitative mass spectrometry, bimolecular fluorescence complementation, chemical cross-linking, and reciprocal coimmunoprecipitation provide further evidence for functional involvement of membrane protein complexes in monolignol biosynthesis.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Interaction between Geminivirus Replication Protein and the SUMO-Conjugating Enzyme Is Required for Viral Infection
JOURNAL OF VIROLOGY, 85(19), 9789–9800.
MeSH headings : Amino Acid Substitution; Binding Sites; DNA Mutational Analysis; Geminiviridae / pathogenicity; Host-Pathogen Interactions; Mutagenesis, Site-Directed; Mutant Proteins / genetics; Mutant Proteins / metabolism; Protein Binding; Protein Interaction Mapping; Sequence Deletion; Tobacco / virology; Ubiquitin-Conjugating Enzymes / metabolism; Viral Proteins / genetics; Viral Proteins / metabolism
TL;DR:
The results established the importance of AL1-SCE1 interactions during geminivirus infection of plants and suggested that AL1 alters the sumoylation of selected host factors to create an environment suitable for viral infection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2011 journal article
Functional Consequences of the Creation of an Asp-His-Fe Triad in a 3/3 Globin
BIOCHEMISTRY, 50(44), 9664–9680.
MeSH headings : Animals; Aspartic Acid / chemistry; Aspartic Acid / genetics; Catalytic Domain / genetics; Crystallography, X-Ray; Electrochemistry; Globins / chemistry; Globins / genetics; Helminth Proteins / chemistry; Helminth Proteins / genetics; Histidine / chemistry; Histidine / genetics; Magnetic Resonance Spectroscopy; Mutagenesis, Site-Directed; Polychaeta / enzymology; Polychaeta / genetics; Spectrophotometry, Ultraviolet; Spectrum Analysis, Raman
TL;DR:
The results suggest that the proximal charge relay in peroxidases regulate the redox potential of the heme Fe but that the trans effect is a carefully balanced property that can both activate H( 2)O(2) and attract ligation by the distal histidine.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Characterization of development and artemisinin biosynthesis in self-pollinated Artemisia annua plants
PLANTA, 234(4), 685–697.
author keywords: Artemisinin; Artemisia annua; HPLC-MS; Metabolic profiling; Self-pollination; Genetic engineering
MeSH headings : Alkyl and Aryl Transferases / genetics; Antimalarials / isolation & purification; Antimalarials / metabolism; Artemisia annua / anatomy & histology; Artemisia annua / chemistry; Artemisia annua / enzymology; Artemisia annua / physiology; Artemisinins / isolation & purification; Artemisinins / metabolism; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System / genetics; Flowers / anatomy & histology; Flowers / chemistry; Flowers / enzymology; Flowers / physiology; Lactones / isolation & purification; Lactones / metabolism; Plant Leaves / anatomy & histology; Plant Leaves / chemistry; Plant Leaves / enzymology; Plant Leaves / physiology; Plant Proteins / genetics; Plants, Medicinal; Pollination / physiology; Seedlings / anatomy & histology; Seedlings / chemistry; Seedlings / enzymology; Seedlings / physiology; Self-Fertilization / physiology; Spectrometry, Mass, Electrospray Ionization; Time Factors
TL;DR:
High performance liquid chromatography–mass spectrometry-based metabolic profiling analyses showed that leaves, flowers, and young seedlings of F2 plants produced artemisinin, and RT-PCR analysis showed that progeny of self-pollinated plants expressed the amorpha-4, 11-diene synthase (ADS) and cytochrome P450 monooxygenase 71 AV1 (CYP71AV1) genes, which are involved in art Artemisia annua
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 review
Anti-biofilm compounds derived from marine sponges
[Review of ]. Marine Drugs, 9(10), 2010–2035.
Source: NC State University Libraries
Added: August 6, 2018
2011 journal article
A bifunctional allosteric site in the dimer interface of procaspase-3
BIOPHYSICAL CHEMISTRY, 159(1), 100–109.
author keywords: Caspase; Apoptosis; Allosteric activator; Drug design; Cancer therapy
MeSH headings : Allosteric Site; Caspase 3 / chemistry; Caspase 3 / metabolism; Enzyme Activation / drug effects; Humans; Models, Molecular; Protein Binding; Protein Multimerization; Small Molecule Libraries / chemistry; Small Molecule Libraries / pharmacology
TL;DR:
This work has utilized the allosteric site of caspase-3 to identify a small molecule activator of procaspase and to characterize its binding to the protease, and suggests that an efficient activator must stabilize the active conformer of the zymogen by expelling the intersubunit linker from the interface.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
Photobactericidal Porphyrin-Cellulose Nanocrystals: Synthesis, Characterization, and Antimicrobial Properties
BIOMACROMOLECULES, 12(10), 3528–3539.
MeSH headings : Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / pharmacology; Azides / chemistry; Cellulose / chemistry; Click Chemistry / methods; Disinfectants / chemical synthesis; Disinfectants / pharmacology; Escherichia coli / drug effects; Escherichia coli / growth & development; Escherichia coli / radiation effects; Humans; Light; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Microbial Viability / drug effects; Microbial Viability / radiation effects; Molecular Structure; Mycobacterium smegmatis / drug effects; Mycobacterium smegmatis / growth & development; Mycobacterium smegmatis / radiation effects; Nanoparticles / chemistry; Nanotechnology / methods; Photosensitizing Agents / chemical synthesis; Photosensitizing Agents / pharmacology; Porphyrins / chemistry; Species Specificity; Staphylococcus aureus / drug effects; Staphylococcus aureus / growth & development; Staphylococcus aureus / radiation effects; Thermogravimetry
TL;DR:
The synthesis, properties, and activity of CNC-Por (5) described herein serve as a benchmark toward the overall objectives of developing novel, potent, bioactive, photobactericidal materials that are effective against a range of bacteria, with potential utilization in the health care and food preparation industries.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Development of a Brain Metastatic Canine Prostate Cancer Cell Line
PROSTATE, 71(12), 1251–1263.
author keywords: prostate cancer; brain metastasis; spinal cord metastasis; dog; canine; bone metastasis
MeSH headings : Adrenal Gland Neoplasms / epidemiology; Adrenal Gland Neoplasms / secondary; Animals; Antineoplastic Agents / pharmacology; Bone Neoplasms / epidemiology; Bone Neoplasms / secondary; Boronic Acids / pharmacology; Bortezomib; Brain Neoplasms / epidemiology; Brain Neoplasms / metabolism; Brain Neoplasms / pathology; Brain Neoplasms / secondary; Carcinogenicity Tests; Carcinoma / epidemiology; Carcinoma / metabolism; Carcinoma / pathology; Carcinoma / secondary; Cell Division; Cell Line, Tumor / drug effects; Cell Line, Tumor / pathology; Dogs; Immunohistochemistry; Incidence; Injections, Subcutaneous; Keratin-18 / metabolism; Keratin-7 / metabolism; Keratin-8 / metabolism; Male; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Connective Tissue / secondary; Parathyroid Hormone-Related Protein / metabolism; Phenylbutyrates / antagonists & inhibitors; Prostatic Neoplasms / pathology; Pyrazines / pharmacology; Reverse Transcriptase Polymerase Chain Reaction; Spinal Cord Neoplasms / epidemiology; Spinal Cord Neoplasms / secondary; Subcutaneous Tissue; Transplantation, Heterologous
TL;DR:
The goal of the study was to establish and characterize a new prostate cancer line derived from a dog with spontaneous prostate cancer.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Development and Application of a Phosphoproteomic Method Using Electrostatic Repulsion-Hydrophilic Interaction Chromatography (ERLIC), IMAC, and LC-MS/MS Analysis to Study Marek's Disease Virus Infection
JOURNAL OF PROTEOME RESEARCH, 10(9), 4041–4053.
author keywords: phosphoproteomics; liquid chromatography; mass spectrometry; Marek's Disease Virus; phosphorylation
MeSH headings : Amino Acid Sequence; Animals; Avian Proteins / analysis; Avian Proteins / metabolism; Chick Embryo; Chromatography, Liquid; Fibroblasts; Host-Pathogen Interactions / physiology; Hydrophobic and Hydrophilic Interactions; Mardivirus; Marek Disease / immunology; Marek Disease / metabolism; Marek Disease / virology; Molecular Sequence Data; Peptide Fragments / analysis; Peptide Fragments / metabolism; Phosphopeptides / analysis; Phosphopeptides / metabolism; Proteomics / methods; Proteomics / standards; Reproducibility of Results; Static Electricity; Tandem Mass Spectrometry; Viral Proteins / analysis; Viral Proteins / metabolism
TL;DR:
An effective separation and enrichment approach is developed to investigate the changes occurring in the phosphoproteome using electrostatic repulsion-hydrophilic interaction chromatography to fractionate peptides from chicken embryo fibroblast (CEF) digests and incorporating a subsequent IMAC enrichment step to selectively target phosphorylated peptides for LC-MS/MS analysis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Quantification of lignin-carbohydrate linkages with high-resolution NMR spectroscopy
PLANTA, 233(6), 1097–1110.
author keywords: Lignin-carbohydrate complex; Benzyl ether LCC linkages; Phenyl glycoside linkages; Ester LCC linkages; Quantitative HSQC NMR technique
MeSH headings : Betula / chemistry; Betula / metabolism; Carbohydrate Conformation; Carbohydrate Metabolism; Carbohydrates / chemistry; Lignin / chemistry; Lignin / metabolism; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular / methods; Pinus taeda / chemistry; Pinus taeda / metabolism; Wood / chemistry
TL;DR:
The data obtained indicate that pinewood contains higher amounts of benzyl ether LCC linkages, but lower amounts of phenyl glycoside and γ-ester LCC moieties as compared to birch wood.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Structural mutants of dengue virus 2 transmembrane domains exhibit host-range phenotype
VIROLOGY JOURNAL, 8.
MeSH headings : Aedes; Amino Acid Sequence; Animals; Antibodies, Neutralizing / blood; Antibodies, Viral / blood; Cell Line; Dengue Virus / genetics; Dengue Virus / immunology; Dengue Virus / pathogenicity; Dengue Virus / physiology; Host Specificity; Mice; Mice, Inbred BALB C; Models, Molecular; Molecular Sequence Data; Mutant Proteins / genetics; Mutant Proteins / immunology; Mutant Proteins / metabolism; Sequence Deletion; Viral Envelope Proteins / genetics; Viral Envelope Proteins / immunology; Viral Envelope Proteins / metabolism
TL;DR:
Novel host-range mutants of DV2 were created that have preferential growth in insect cells and impaired infectivity in mammalian cells and may be applied to many other insect-borne viral diseases for which no current effective therapies exist.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Comparative Analysis of the 15.5kD Box C/D snoRNP Core Protein in the Primitive Eukaryote Giardia lamblia Reveals Unique Structural and Functional Features
BIOCHEMISTRY, 50(14), 2907–2918.
MeSH headings : Amino Acid Sequence; Animals; Binding Sites / genetics; Circular Dichroism; Crystallography, X-Ray; Giardia lamblia / metabolism; Humans; Methyltransferases / chemistry; Methyltransferases / metabolism; Models, Molecular; Molecular Sequence Data; Molecular Weight; Phylogeny; Protein Binding; Protein Stability; Protein Structure, Secondary; Protein Structure, Tertiary; Protozoan Proteins / chemistry; Protozoan Proteins / genetics; Protozoan Proteins / metabolism; RNA / genetics; RNA / metabolism; Ribonucleoproteins, Small Nucleolar / chemistry; Ribonucleoproteins, Small Nucleolar / classification; Ribonucleoproteins, Small Nucleolar / metabolism; Sequence Homology, Amino Acid; Temperature
TL;DR:
Comp comparative sequence analysis indicated a distinct evolutionary position between Archaea and Eukarya, and the Giardia 15.5kD protein occupies a unique position in the evolution of this box C/D RNP core protein retaining structural and functional features characteristic of both archaeal L7Ae and higher eukaryotic 15.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Alphavirus adsorption to mosquito cells as viewed by freeze fracture immunolabeling
VIROLOGY, 415(2), 132–140.
author keywords: Alphavirus; Cell penetration; Insect cells; Freeze-fracture; Electron microscopy
MeSH headings : Adsorption; Alphavirus / chemistry; Alphavirus / physiology; Alphavirus / ultrastructure; Animals; Cell Membrane / chemistry; Cell Membrane / ultrastructure; Cell Membrane / virology; Cells, Cultured; Culicidae / virology; Freeze Fracturing / methods; Immunohistochemistry / methods
TL;DR:
Using freeze-fracture replicas, thin-sections and antibody labeling the data suggest that the intramembrane particles associated with SV may be part of the pore structure consisting of virus proteins and cell receptor.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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