Works Published in 2012
Displaying works 1 - 20 of 41 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2012 report
Attenuated FNR Deficient Enterobacteria
(US Patent No. 8,101,168).
Source: NC State University Libraries
Added: March 12, 2022
2012 journal article
CIRCADIAN CLOCK-ASSOCIATED 1 regulates ROS homeostasis and oxidative stress responses.
Proceedings of the National Academy of Sciences of the United States of America.
author keywords: redox homeostasis; transcriptional coordination
MeSH headings : Arabidopsis / physiology; Arabidopsis Proteins / genetics; Arabidopsis Proteins / metabolism; Arabidopsis Proteins / physiology; Chromatin Immunoprecipitation; Computational Biology; Gene Expression Regulation, Plant / genetics; Gene Expression Regulation, Plant / physiology; Homeostasis / genetics; Homeostasis / physiology; Luminescent Measurements; Mutation / genetics; Oxidative Stress / physiology; Polymerase Chain Reaction; Reactive Oxygen Species / metabolism; Transcription Factors / genetics; Transcription Factors / metabolism; Transcription Factors / physiology
TL;DR:
This work proposes CCA1 as a master regulator of ROS homeostasis through association with the Evening Element in promoters of ROS genes in vivo to coordinate time-dependent responses to oxidative stress.
(via Semantic Scholar)
www.pnas.org (publisher PDF)
Source: ORCID
Added: January 25, 2021
2012 journal article
Circadian surprise--it's not all about transcription.
Science (New York, N.Y.).
MeSH headings : Animals; CLOCK Proteins / genetics; Chromatin / metabolism; Circadian Clocks / genetics; Circadian Rhythm / genetics; Cryptochromes / genetics; Epigenesis, Genetic; Gene Expression Regulation; Liver / physiology; Male; RNA-Binding Proteins / metabolism; Transcription, Genetic; Transcriptional Activation
TL;DR:
This issue focuses on the importance of posttranscriptional regulation of messenger RNA levels on the clock, and investigates this problem from opposite ends of the spectrum—a genome-wide discovery approach and the functional characterization of a specific factor.
(via Semantic Scholar)
Source: ORCID
Added: January 25, 2021
2012 journal article
UDP-glucose Dehydrogenase Polymorphisms from Patients with Congenital Heart Valve Defects Disrupt Enzyme Stability and Quaternary Assembly
Journal of Biological Chemistry, 287(39), 32708–32716.
MeSH headings : Amino Acid Substitution; Animals; Animals, Genetically Modified / embryology; Animals, Genetically Modified / genetics; Enzyme Stability / genetics; Escherichia coli; Heart Defects, Congenital / embryology; Heart Defects, Congenital / enzymology; Heart Defects, Congenital / genetics; Heart Valve Diseases / embryology; Heart Valve Diseases / enzymology; Heart Valve Diseases / genetics; Heart Valves / embryology; Heart Valves / enzymology; Muscle Proteins / genetics; Muscle Proteins / metabolism; Mutation, Missense; Polymorphism, Genetic; Protein Structure, Quaternary; Recombinant Proteins / genetics; Recombinant Proteins / metabolism; Uridine Diphosphate Glucose Dehydrogenase; Zebrafish / embryology; Zebrafish / genetics; Zebrafish Proteins / genetics; Zebrafish Proteins / metabolism
TL;DR:
UGDH loss of function mutations result in a subset of human congenital cardiac valve defects caused by reduced enzyme activity during morphogenesis, consistent with the reduced function of both missense mutations significantly reducing the ability of UGDH to provide precursors for cardiac cushion formation, which is essential to subsequent valve formation.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2012 journal article
Arabidopsis circadian clock protein, TOC1, is a DNA-binding transcription factor.
Proceedings of the National Academy of Sciences of the United States of America.
author keywords: transcriptional regulation; transcriptional potential; gene networks; circadian outputs; diurnal
MeSH headings : Amino Acid Sequence; Arabidopsis / genetics; Arabidopsis / metabolism; Arabidopsis Proteins / chemistry; Arabidopsis Proteins / genetics; Arabidopsis Proteins / metabolism; Base Sequence; Circadian Clocks / genetics; DNA, Plant / metabolism; DNA-Binding Proteins / chemistry; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Gene Expression Regulation, Plant; Genes, Plant / genetics; Molecular Sequence Data; Promoter Regions, Genetic / genetics; Protein Binding; Protein Structure, Tertiary; Repressor Proteins / metabolism; Transcription Factors / chemistry; Transcription Factors / genetics; Transcription Factors / metabolism; Transcription, Genetic
TL;DR:
A biochemical action is defined for the core clock protein TOC1 that acts as a general transcriptional repressor, and that repression activity is in the pseudoreceiver domain of the protein.
(via Semantic Scholar)
Source: ORCID
Added: June 25, 2019
2012 journal article
A Novel DNA Binding Mechanism for maf Basic Region-Leucine Zipper Factors Inferred from a MafA-DNA Complex Structure and Binding Specificities
BIOCHEMISTRY, 51(48), 9706–9717.
MeSH headings : Amino Acid Sequence; Base Sequence; Crystallography, X-Ray; DNA / metabolism; DNA Primers; Electrophoretic Mobility Shift Assay; Leucine Zippers; Maf Transcription Factors, Large / chemistry; Maf Transcription Factors, Large / metabolism; Molecular Sequence Data; Protein Binding; Protein Conformation; Sequence Homology, Amino Acid
TL;DR:
Results suggest a novel multistep DNA binding process involving a conformational change from contacting the core-TGA to contacting the flanking-TGC bases, which is critical for insulin gene expression in pancreatic β-cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2012 journal article
Testing of Novel Dengue Virus 2 Vaccines in African Green Monkeys: Safety, Immunogenicity, and Efficacy
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 87(4), 743–753.
MeSH headings : Animals; Antibodies, Neutralizing / blood; Antibodies, Viral / blood; Cells, Cultured; Chlorocebus aethiops; Dengue / immunology; Dengue / prevention & control; Dengue / virology; Dengue Vaccines / adverse effects; Dengue Vaccines / genetics; Dengue Vaccines / immunology; Dengue Vaccines / therapeutic use; Dengue Virus / genetics; Dengue Virus / immunology; Immunization; Neutralization Tests; Viral Envelope Proteins / genetics; Viral Envelope Proteins / immunology; Viral Plaque Assay
TL;DR:
Three novel host-range vaccines containing deletions in the transmembrane domain of dengue virus serotype 2 (DV2) E glycoprotein were evaluated in African green monkeys, and all three vaccine strains decreased the length of viremia by at least two days.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Structurally Conserved Nop56/58 N-terminal Domain Facilitates Archaeal Box C/D Ribonucleoprotein-guided Methyltransferase Activity
JOURNAL OF BIOLOGICAL CHEMISTRY, 287(23), 19418–19428.
MeSH headings : Archaeal Proteins / chemistry; Archaeal Proteins / genetics; Archaeal Proteins / metabolism; Chromosomal Proteins, Non-Histone / chemistry; Chromosomal Proteins, Non-Histone / genetics; Chromosomal Proteins, Non-Histone / metabolism; Methanococcales / chemistry; Methanococcales / genetics; Methanococcales / metabolism; Methyltransferases / chemistry; Methyltransferases / genetics; Methyltransferases / metabolism; Protein Binding; Protein Structure, Tertiary; Ribonucleoproteins / chemistry; Ribonucleoproteins / genetics; Ribonucleoproteins / metabolism
TL;DR:
The archaeal Nop56/58 NTD exhibits a conserved domain structure whose exceptionally stable interaction with fibrillarin plays a role in both RNP assembly and methyltransferase activity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Splice variant of the SND1 transcription factor is a dominant negative of SND1 members and their regulation in Populus trichocarpa
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(36), 14699–14704.
MeSH headings : Blotting, Western; Cloning, Molecular; DNA Primers / genetics; Dimerization; Electrophoresis, Polyacrylamide Gel; Gene Regulatory Networks / genetics; Homeostasis / physiology; Models, Biological; Plasmids / genetics; Populus / genetics; Protein Isoforms / genetics; Protein Transport; Real-Time Polymerase Chain Reaction; Transcription Factors / genetics
TL;DR:
A stem-differentiating xylem (SDX)-specific alternative SND1 splice variant, PtrSND1-A2IR, that acts as a dominant negative of S ND1 transcriptional network genes in Populus trichocarpa is discovered and may contribute to transcriptional homeostasis to avoid deleterious effects on xylogenesis and plant growth.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2012 conference paper
Seeking novel Leishmanicidal natural products from common medicinal plants, the example of Eryngium foetidum L
Planta Medica, 78(11), 1132–1132.
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
MicroRNAs in trees
PLANT MOLECULAR BIOLOGY, 80(1), 37–53.
author keywords: MicroRNA; Woody plant; Gene regulation; Plant development; Plant stress response; Artificial microRNA
MeSH headings : Gene Expression Regulation, Plant; MicroRNAs / genetics; MicroRNAs / metabolism; Models, Genetic; Phylogeny; Plants, Genetically Modified / genetics; Plants, Genetically Modified / metabolism; RNA, Messenger / genetics; RNA, Messenger / metabolism; RNA, Plant / genetics; RNA, Plant / metabolism; Trees / classification; Trees / genetics; Trees / metabolism
TL;DR:
The purpose of this review is to summarize the current status of information on mi RNAs in trees and to guide future studies on the role of miRNAs in the biology of woody perennials and to illustrate their utility in directed genetic modification of trees.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
H-1, C-13, and N-15 resonance assignments and secondary structure prediction of the full-length transition state regulator AbrB from Bacillus anthracis
BIOMOLECULAR NMR ASSIGNMENTS, 6(1), 95–98.
author keywords: AbrB; NMR; Bacillus anthracis; Transition state regulator
MeSH headings : Bacillus anthracis; Bacterial Proteins / chemistry; DNA-Binding Proteins / chemistry; Nuclear Magnetic Resonance, Biomolecular; Protein Structure, Secondary; Transcription Factors / chemistry
TL;DR:
Backbone and sidechain resonance assignments and secondary structure prediction for the full-length AbrB protein from B. anthracis are reported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Open Conformation of Ezrin Bound to Phosphatidylinositol 4,5-Bisphosphate and to F-actin Revealed by Neutron Scattering
JOURNAL OF BIOLOGICAL CHEMISTRY, 287(44), 37119–37133.
MeSH headings : Actins / chemistry; Amino Acid Substitution; Cytoskeletal Proteins / chemistry; Cytoskeletal Proteins / genetics; Humans; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Neutron Diffraction; Phosphatidylinositol 4,5-Diphosphate / chemistry; Phosphoproteins / chemistry; Phosphoproteins / genetics; Protein Binding; Protein Structure, Quaternary; Protein Structure, Tertiary; Scattering, Small Angle; Sodium-Hydrogen Exchangers / chemistry; Surface Plasmon Resonance; X-Ray Diffraction
TL;DR:
The study provides the first structural view of the activated ezrin bound to PIP2 and to F-actin, suggesting a possible role of eZrin in regulating the interfacial structure and dynamics between the cell membrane and the underlying actin cytoskeleton.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2012 journal article
Identification of BfmR, a Response Regulator Involved in Biofilm Development, as a Target for a 2-Aminoimidazole-Based Antibiofilm Agent
BIOCHEMISTRY, 51(49), 9776–9778.
MeSH headings : Acinetobacter baumannii / drug effects; Acinetobacter baumannii / growth & development; Bacterial Proteins / chemistry; Bacterial Proteins / physiology; Biofilms / drug effects; Imidazoles / pharmacology; Microscopy, Confocal; Models, Molecular
TL;DR:
The 2AI compound studied here represents a unique small molecule scaffold that targets bacterial response regulators and is cell permeable, while pull-down assays identified BfmR, a response regulator that is the master controller of biofilm formation, as a target for this compound.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Functional redundancy of the two 5-hydroxylases in monolignol biosynthesis of Populus trichocarpa: LC-MS/MS based protein quantification and metabolic flux analysis
PLANTA, 236(3), 795–808.
author keywords: Lignin; Syringyl lignin; Angiosperm; Kinetics; Subcellular localization
MeSH headings : Cloning, Molecular; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Plant; Hydroxylation; Kinetics; Lignin / analysis; Lignin / biosynthesis; Mixed Function Oxygenases / metabolism; Plants, Genetically Modified; Populus / metabolism; Xylem / enzymology; Yeasts / metabolism
TL;DR:
The combination of genetic analysis, absolute protein quantitation-based enzyme kinetics, homologous CPR specificity, SNP characterization, and ER localization provides a more rigorous basis for a comprehensive systems understanding of 5-hydroxylation in lignin biosynthesis.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Comparison of Health-Relevant Flavonoids in Commonly Consumed Cranberry Products
JOURNAL OF FOOD SCIENCE, 77(8), H176–H183.
author keywords: anthocyanins; cranberry; flavonoids; proanthocyanidins; processing
MeSH headings : Anthocyanins / analysis; Beverages; Biflavonoids / analysis; Catechin / analysis; Chromatography, High Pressure Liquid; Flavonoids / analysis; Food Handling / methods; Freeze Drying; Fruit / chemistry; Plant Extracts / analysis; Proanthocyanidins / analysis; Vaccinium macrocarpon / chemistry
TL;DR:
As cranberry juices and other products are increasingly consumed for their recognized health benefits (including prophylaxis against urinary tract infection), it is relevant to consider how various degrees of commercial and home processing can alter innate levels of the biologically active flavonoids characteristic to the intact fruits.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
A standard reaction condition and a single HPLC separation system are sufficient for estimation of monolignol biosynthetic pathway enzyme activities
PLANTA, 236(3), 879–885.
author keywords: Monolignols; Enzyme activity; Populus trichocarpa; Pinus taeda; Angiosperm; Gymnosperm
MeSH headings : Biosynthetic Pathways; Chromatography, High Pressure Liquid; Enzyme Assays; Lignin / biosynthesis; Methyltransferases / metabolism; Mixed Function Oxygenases / metabolism; Oxidoreductases / metabolism; Pinus taeda / enzymology; Plant Proteins / analysis; Plant Stems / enzymology; Populus / enzymology; Substrate Specificity; Xylem / enzymology
TL;DR:
This work developed a method using a total protein extract (soluble and microsomal) for the comprehensive and simultaneous analysis of these ten enzyme activities in a single target tissue, stem differentiating xylem (SDX) of Populustrichocarpa.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Isolation and characterization of flavonols from blackcurrant by high-performance counter-current chromatography and electrospray ionization tandem mass spectrometry
JOURNAL OF SEPARATION SCIENCE, 35(13), 1682–1689.
author keywords: Blackcurrant (Ribes nigrum); Flavonols; High-performance counter-current chromatography; Liquid chromatography with tandem mass spectrometry
MeSH headings : Countercurrent Distribution / methods; Flavonols / chemistry; Flavonols / isolation & purification; Plant Extracts / chemistry; Plant Extracts / isolation & purification; Ribes / chemistry; Spectrometry, Mass, Electrospray Ionization / methods
TL;DR:
The results of these experiments demonstrated that high-performance counter-current chromatography along with ESI-MS(n) is a sensitive, selective, and effective technology for isolation and characterization of minor constituents from a complex mixture.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 article
Functional Recognition of the Modified Human tRNA (Lys3) (UUU) Anticodon Domain by HIV's Nucleocapsid Protein and a Peptide Mimic (vol 410, pg 698, year 2011)
Journal of Molecular Biology, Vol. 420, pp. 259–259.
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
Direct fed microbial supplementation repartitions host energy to the immune system
JOURNAL OF ANIMAL SCIENCE, 90(8), 2639–2651.
author keywords: broiler; direct fed microbials; energy metabolism; gene expression; probiotics; systemic immune function
MeSH headings : Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Chickens / immunology; Chickens / metabolism; Diet / veterinary; Dietary Supplements; Energy Metabolism / immunology; Enzyme-Linked Immunosorbent Assay; Erythrocytes / immunology; Gene Expression Regulation / immunology; Gram-Positive Bacteria / physiology; Immunoglobulin A / blood; Immunoglobulin G / blood; Male; Oxygen Consumption; Sheep; Time Factors
TL;DR:
Data indicate that supplementation with the direct fed microbial used in this study resulted in energy re-partitioning to the immune system and an increase in antibody production independent of changes in whole body metabolism or growth performance.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
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