TY - JOUR
TI - sn-l, 2-Diacylglycerols mimic the effects of 12-0-tetradecanoylphorbol-13-acetate in vivo by inducing biochemical changes associated with tumor promotion in mouse epidermis
AU - Smart, Robert C.
AU - Huang, Mou-Tuan
AU - Conney, Allan H.
T2 - Carcinogenesis
AB - 12-O-Tetradecanoylphorbol-13 acetate (TPA) or various acylglycerols were applied topically to CD-1 mice, and biochemical changes associated with tumor promotion in the epidermis were examined. The topical application of 5 mumol of sn-1,2-didecanoylglycerol caused a 40-fold increase in ornithine decarboxylase activity which was similar to that found after the topical application of 2 nmol of TPA. The time course for the induction of ornithine decarboxylase activity by TPA and the time course for its induction by sn-1,2-didecanoylglycerol were similar; both compounds produced rapid increases in ornithine decarboxylase activity with peak induction occurring 4-6 h after application of the inducing chemical. sn-1,2-Dioctanoylglycerol and sn-1-oleoyl-2-acetylglycerol also increased ornithine decarboxylase activity in mouse epidermis, but sn-1,2-dioleoylglycerol, 1,3-didecanoylglycerol and rac-1-monodecanoylglycerol were inactive at the dose tested. trans-Retinoic acid, a potent inhibitor of tumor promotion, markedly inhibited the epidermal induction of ornithine decarboxylase activity that resulted from the topical administration of sn-1,2-didecanoylglycerol or TPA. The effects of TPA and the acylglycerols on epidermal DNA synthesis in vivo were determined by measuring the incorporation of [3H]thymidine into epidermal DNA. The application of sn-1,2-didecanoylglycerol or TPA to mouse skin stimulated epidermal DNA synthesis. The maximum increase occurred 18 h after administration of the inducing chemical, and the increase in DNA synthesis was proportional to the dose of sn-1,2-didecanoylglycerol. Although sn-1,2-didecanoylglycerol, sn-1,2-dioctanoylglycerol and sn-1,2-dioleoylglycerol stimulated epidermal DNA synthesis, sn-1-oleoyl-2-acetylglycerol, 1,3-didecanoylglycerol and rac-1-monodecanoylglycerol had little or no effect. The increase in epidermal DNA synthesis induced by sn-1,2-didecanoylglycerol or TPA was inhibited by the simultaneous application of fluocinolone acetonide, a potent inhibitor of tumor promotion. The results indicate that several sn-1,2-diacylglycerols mimic TPA in vivo with respect to their effects on certain biochemical parameters associated with tumor promotion in mouse skin.
DA - 1986///
PY - 1986///
DO - 10.1093/carcin/7.11.1865
VL - 7
IS - 11
SP - 1865-1870
J2 - Carcinogenesis
LA - en
OP -
SN - 0143-3334 1460-2180
UR - http://dx.doi.org/10.1093/carcin/7.11.1865
DB - Crossref
ER -
TY - JOUR
TI - Effect of ellagic acid and 3-O-decylellagic acid on the formation of benzo[a]pyrene-derived DNA adducts in vivo and on the tumorigenicity of 3-methylcholanthrene in mice
AU - Smart, Robert C.
AU - Huang, Mou-Tuan
AU - Chang, Richard L.
AU - Sayer, Jane M.
AU - Jerina, Donald M.
AU - Wood, Alexander W.
AU - Conney, Allan H.
T2 - Carcinogenesis
AB - The effect of ellagic acid and its more lipophilic derivative, 3- O -decylellagic acid, on the amount of DNA-bound adducts in the epidermis or lung of CD-I mice treated with [ 3 H]benzo-[a]pyrene ([ 3 H]B[a]P) was evaluated using several different treatment protocols. The i.v. administration of 50μmol/kg of ellagic acid or 3- O -decyIellagk acid either together with or 5 min before a 0.2 μmol/kg i.v. dose of [ 3 H]B[a]P did not inhibit the formation of pulmonary DNA-bound adducts. Feeding mice a diet that contained 1% ellagic acid for 10 days or the i.p. administration of 120 μmol/kg of ellagic acid 30 min before the i.v. administration of 0.2 μmol/kg of [ 3 H)B(a)P did not inhibit the formation of DNA-bound adducts in the lung. The application of 2500 nmol of ellagic acid or 3- O -decylellagic acid to mouse skin 5 min before the application of 2, 10 or 50 nmol of [ 3 H]B[a]P had little or no effect on the covalent binding of [ 3 H]B[a]P metabolites to epidermal DNA. Feeding mice a diet containing 1% ellagic acid for 10 days did not inhibit the formation of epidermal DNA-bound adducts after a topical dose of 2 nmol of [ 3 H]B[a]P. Similarly, the topical application of 2500 nmol of ellagic acid at 2 h, 1 h and 5 min before and at 10 min after the application of 2 nmol of [ 3 H]B[a]P did not inhibit the formation of DNA-bound adducts, but the same dosing regimen of 3- O -decylellagic acid (total dose of 10 000 nmol) resulted in a modest inhibition in the formation of DNA-bound adducts. The topical application of 1500 nmol of ellagic acid 1 h before the application of 1500 nmol of 3-methylcholanthrene (3-MC) to CD-I or BALB/c mice twice weekly did not inhibit the development of skin tumors. Our results indicate that ellagic acid and 3- O -decylellagic acid are not effective in inhibiting [ 3 H]B[a]P DNA adduct formation in mouse skin and lung and that ellagic acid does not inhibit 3-MC-induced skin tumori-genesis in BALB/c or CD-I mice.
DA - 1986///
PY - 1986///
DO - 10.1093/carcin/7.10.1669
VL - 7
IS - 10
SP - 1669-1675
J2 - Carcinogenesis
LA - en
OP -
SN - 0143-3334 1460-2180
UR - http://dx.doi.org/10.1093/carcin/7.10.1669
DB - Crossref
ER -
TY - JOUR
TI - Disposition of the naturally occurring antimutagenic plant phenol, ellagic acid, and its synthetic derivatives, 3-O-decylellagic acid and 3, 3'-di-O-methylellagic acid in mice
AU - Smart, Robert C.
AU - Huang, Mou-Tuan
AU - Chang, Richard L.
AU - Sayer, Jane M.
AU - Jerina, Donald M.
AU - Conney, Allan H.
T2 - Carcinogenesis
AB - Journal Article Disposition of the naturally occurring antimutagenic plant phenol, ellagic acid, and its synthetic derivatives, 3- O -decylellagic acid and 3, 3'-di- O -methylellagic acid in mice Get access Robert C. Smart, Robert C. Smart Search for other works by this author on: Oxford Academic PubMed Google Scholar Mou-Tuan Huang, Mou-Tuan Huang Search for other works by this author on: Oxford Academic PubMed Google Scholar Richard L. Chang, Richard L. Chang Search for other works by this author on: Oxford Academic PubMed Google Scholar Jane M. Sayer, Jane M. Sayer 1Section on Oxidation Mechanisms, Laboratory of Bioorganic Chemistry, National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, National Institutes of HealthBethesda, MD 20892, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Donald M. Jerina, Donald M. Jerina 1Section on Oxidation Mechanisms, Laboratory of Bioorganic Chemistry, National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, National Institutes of HealthBethesda, MD 20892, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Allan H. Conney Allan H. Conney Search for other works by this author on: Oxford Academic PubMed Google Scholar Carcinogenesis, Volume 7, Issue 10, October 1986, Pages 1663–1667, https://doi.org/10.1093/carcin/7.10.1663 Published: 01 October 1986 Article history Received: 06 March 1986 Accepted: 03 July 1986 Published: 01 October 1986
DA - 1986///
PY - 1986///
DO - 10.1093/carcin/7.10.1663
VL - 7
IS - 10
SP - 1663-1667
J2 - Carcinogenesis
LA - en
OP -
SN - 0143-3334 1460-2180
UR - http://dx.doi.org/10.1093/carcin/7.10.1663
DB - Crossref
ER -
TY - JOUR
TI - Effect of dietary ascorbate on covalent binding of benzene to bone marrow and hepatic tissue in vivo
AU - Smart, Robert C.
AU - Zannoni, Vincent G.
T2 - Biochemical Pharmacology
AB - The bio-elimination and organ retention of orally administered [14C]benzanthrone, an anthraquinone dye intermediate, were determined in control and ascorbic acid-supplemented guinea pigs. Urinary excretion of benzanthrone in control and ascorbic acid-treated animals during 96 hr was 27.9 and 30.5%, respectively, with peak elimination at 48 hr. Faecal elimination in control and supplemented animals during 96 hr was 24.5 and 38.8%, respectively, with a peak at 48 hr. The organ retention of radiolabelled benzanthrone at the end of 96 hr was of the order of 39% in control animals (gastrointestinal tract 16%; liver 22%; testis 1.2%); ascorbic acid supplementation reduced benzanthrone retention to 19.5% (gastro-intestinal tract 12.7%; liver 6.8%). Overall, pretreatment of guinea pigs with ascorbic acid caused a 32% enhancement in the clearance of radiolabelled benzanthrone through the urine and faeces, while organ retention was reduced by about 50%. A prophylactic dose of ascorbic acid may prevent benzanthrone-induced toxic symptoms in exposed workers.
DA - 1986/9//
PY - 1986/9//
DO - 10.1016/0006-2952(86)90409-0
VL - 35
IS - 18
SP - 3180-3182
J2 - Biochemical Pharmacology
LA - en
OP -
SN - 0006-2952
UR - http://dx.doi.org/10.1016/0006-2952(86)90409-0
DB - Crossref
ER -
TY - JOUR
TI - Serum thyroxine concentrations after radioactive iodine therapy in cats with hyperthyroidism.
T2 - Journal of the American Veterinary Medical Association
DA - 1986/5/1/
PY - 1986/5/1/
ER -
TY - JOUR
TI - Inconsistencies in the absorptive capacities of Schirmer tear test strips.
T2 - Journal of the American Veterinary Medical Association
DA - 1986/3/1/
PY - 1986/3/1/
ER -
TY - JOUR
TI - Immunoglobulin A myeloma in a cat with pleural effusion and serum hyperviscosity.
T2 - Journal of the American Veterinary Medical Association
DA - 1986/4/1/
PY - 1986/4/1/
ER -
TY - JOUR
TI - Digestion of bentiromide and absorption of xylose in healthy cats and absorption of xylose in cats with infiltrative intestinal disease.
T2 - American journal of veterinary research
DA - 1986/3/1/
PY - 1986/3/1/
ER -
TY - JOUR
TI - Use of tears for diagnosis of feline leukemia virus infection.
T2 - Journal of the American Veterinary Medical Association
DA - 1986/5/1/
PY - 1986/5/1/
ER -
TY - CONF
TI - Morphological, Cultural And Epidemiological Investigations of the Aphanomyces Sp. Associated With Menhaden Ulcerative Mycosis (MUM)
AU - Dykstra, M.J.
AU - Noga, E.J.
AU - Levine, J.F.
T2 - Mycological Society of America
C2 - 1986/8//
DA - 1986/8//
PY - 1986/8//
ER -
TY - CONF
TI - The Pathological, Biological, and Epidemiological Aspects of an Epidemic Disease Problem In Estuarine Fishes
AU - Noga, E.J.
AU - Dykstra, M.J.
AU - Levine, J.F.
T2 - International Conference on Water And Human Health
C2 - 1986///
DA - 1986///
PY - 1986/11//
ER -
TY - CONF
TI - Ulcerative Mycosis of Estuarine Fishes; Biology and Pathology of the Fungal Pathogen
AU - Noga, E.J.
AU - Dykstra, M.J.
AU - Levine, J.F.
T2 - Eastern Fish Health Workshop
C2 - 1986///
DA - 1986///
PY - 1986/7//
ER -
TY - CONF
TI - Survival After Cardiopulmonary Resuscitations in Canine Patients
AU - Gilroy, B.A.
AU - Levine, J.F.
T2 - Veterinary Emergency and Critical Care
C2 - 1986/4//
DA - 1986/4//
PY - 1986/4//
ER -
TY - CONF
TI - Growth Requirements for an Aphanomyces Isolate Associated with the Fish Disease Menhaden Ulcerative Mycosis
AU - Dykstra, M.J.
AU - Noga, E.J.
AU - Levine, J.F.
T2 - American Society for Microbiology
C2 - 1986/3//
DA - 1986/3//
PY - 1986/3//
ER -
TY - CONF
TI - Ulcerative Mycosis: Epidemiology
AU - Levine, J.F.
AU - Hawkins, J.H.
T2 - Neuse River Foundation Water Quality Symposium
C2 - 1986/11//
CY - New Bern, North Carolina
DA - 1986/11//
PY - 1986/11//
ER -
TY - JOUR
TI - Natures Adaptable Tick
AU - Levine, J.F.
T2 - North Carolina Wildlife Notebook
DA - 1986///
PY - 1986///
VL - 6
SP - 1–4
ER -
TY - JOUR
TI - Hollow Fiber Microfiltration Methods for Recovery of Rat Basophilic Leukemia Cells (RBL-2H3) From Tissue Culture Media
AU - Shiloach, Joseph
AU - Kaufman, Jeanne B.
AU - Kelly, Robert M.
T2 - Biotechnology Progress
AB - Biotechnology ProgressVolume 2, Issue 4 p. 230-233 Article Hollow Fiber Microfiltration Methods for Recovery of Rat Basophilic Leukemia Cells (RBL—2H3) From Tissue Culture Media Joseph Shiloach, Joseph Shiloach Biotechnology Unit, NIDDK, National Institutes of Health, Bethesda, Maryland 20892 Joseph Shiloach: is the head of the Biotechnology (Pilot Plant) Unit at the National Institutes of Health in Bethesda, Maryland. He received his Ph.D. from the Hebrew University in Jerusalem, Israel. He is heavily involved in fermentation processes, mammalian cell growth and recovery process of compounds with biological activity.Search for more papers by this authorJeanne B. Kaufman, Jeanne B. Kaufman Biotechnology Unit, NIDDK, National Institutes of Health, Bethesda, Maryland 20892 Jeanne Kaufman: received her B.S. in Biology at St. Mary's College in Maryland. She is currently with the Biotechnology unit at the National Institutes of Health. She is responsible for the growth of the mammalian cell culture on small and large scale.Search for more papers by this authorRobert M. Kelly, Robert M. Kelly Department of Chemical Engineering, The Johns Hopkins University, Baltimore, Maryland 21218 Robert M. Kelly: is currently assistant professor of chemical engineering at the Johns Hopkins University in Baltimore, Maryland where he has been since 1981. He received his Ph.D. in chemical engineering from North Carolina State University. His research interests include separation processes, especially chemical absorption and stripping, and biochemical engineering with emphasis on engineering problems related to the growth and utilization of bacteria from extreme environments.Search for more papers by this author Joseph Shiloach, Joseph Shiloach Biotechnology Unit, NIDDK, National Institutes of Health, Bethesda, Maryland 20892 Joseph Shiloach: is the head of the Biotechnology (Pilot Plant) Unit at the National Institutes of Health in Bethesda, Maryland. He received his Ph.D. from the Hebrew University in Jerusalem, Israel. He is heavily involved in fermentation processes, mammalian cell growth and recovery process of compounds with biological activity.Search for more papers by this authorJeanne B. Kaufman, Jeanne B. Kaufman Biotechnology Unit, NIDDK, National Institutes of Health, Bethesda, Maryland 20892 Jeanne Kaufman: received her B.S. in Biology at St. Mary's College in Maryland. She is currently with the Biotechnology unit at the National Institutes of Health. She is responsible for the growth of the mammalian cell culture on small and large scale.Search for more papers by this authorRobert M. Kelly, Robert M. Kelly Department of Chemical Engineering, The Johns Hopkins University, Baltimore, Maryland 21218 Robert M. Kelly: is currently assistant professor of chemical engineering at the Johns Hopkins University in Baltimore, Maryland where he has been since 1981. He received his Ph.D. in chemical engineering from North Carolina State University. His research interests include separation processes, especially chemical absorption and stripping, and biochemical engineering with emphasis on engineering problems related to the growth and utilization of bacteria from extreme environments.Search for more papers by this author First published: December 1986 https://doi.org/10.1002/btpr.5420020411Citations: 9 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Citing Literature Volume2, Issue4December 1986Pages 230-233 RelatedInformation
DA - 1986/12//
PY - 1986/12//
DO - 10.1002/btpr.5420020411
VL - 2
IS - 4
SP - 230-233
J2 - Biotechnol Progress
LA - en
OP -
SN - 8756-7938 1520-6033
UR - http://dx.doi.org/10.1002/btpr.5420020411
DB - Crossref
ER -
TY - JOUR
TI - Experimental methods for measuring static liquid holdup in packed columns
AU - Schubert, C. N.
AU - Lindner, J. R.
AU - Kelly, R. M.
T2 - AIChE Journal
AB - AIChE JournalVolume 32, Issue 11 p. 1920-1923 R & D Note Experimental methods for measuring static liquid holdup in packed columns C. N. Schubert, C. N. Schubert Department of Chemical Engineering, Johns Hopkins University, Baltimore, MD 21218Search for more papers by this authorJ. R. Lindner, J. R. Lindner Department of Chemical Engineering, Johns Hopkins University, Baltimore, MD 21218Search for more papers by this authorR. M. Kelly, Corresponding Author R. M. Kelly Department of Chemical Engineering, Johns Hopkins University, Baltimore, MD 21218Department of Chemical Engineering, Johns Hopkins University, Baltimore, MD 21218Search for more papers by this author C. N. Schubert, C. N. Schubert Department of Chemical Engineering, Johns Hopkins University, Baltimore, MD 21218Search for more papers by this authorJ. R. Lindner, J. R. Lindner Department of Chemical Engineering, Johns Hopkins University, Baltimore, MD 21218Search for more papers by this authorR. M. Kelly, Corresponding Author R. M. Kelly Department of Chemical Engineering, Johns Hopkins University, Baltimore, MD 21218Department of Chemical Engineering, Johns Hopkins University, Baltimore, MD 21218Search for more papers by this author First published: November 1986 https://doi.org/10.1002/aic.690321119Citations: 29AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Literature cited Baldi, G., and S., Sicardi, “A Model for Mass Transfer with and without Chemical Reaction in Packed Towers,” Chem. Eng. Sci., 30, 617 (1975). Bennett, A., and F., Goodridge, “Hydrodynamic and Mass Transfer Studies in Packed Absorption Columns,” Trans. Inst. Chem. Engrs., 48, T232 (1970). Hoogendoorn, C. J., and J., Lips, “Axial Mixing of Liquid in Gas-Liquid Flow through Packed Beds,” Can. J. Chem. Eng., 43, 125 (1965). Joosten, G. E. H., and P. V., Dankwerts, “Chemical Reaction and Effective Interfacial Areas in Gas Absorption,” Chem. Eng. Sci., 28, 453 (1973). Patwardhan, V. S., “Effective Interfacial Area in Packed Beds for Absorption with Chemical Reaction,” Can. J. Chem. Eng., 56, 56 (1978). Patwardhan, V. S., and V. R., Shrotri, “Mass Transfer Coefficient between the Static and Dynamic Holdups in a Packed Column,” Chem. Eng. Commun., 10, 349 (1981). Puranik, S. S., and A., Vogelpohl, “Effective Interfacial Area in Irrigated Packed Columns,” Chem. Eng. Sci., 29, 501 (1974). Ruszkay, R. D., “ Transient Response of Liquid Flowing through Packed Tower with Air Counterflow,” Ph.D. Thesis, Columbia Univ. (1963). Shulman, H. L., C. F., Ullrich, and N. Wells, “Performance of Packed Columns. 1: Total, Static, and Operating Holdups,” AIChE J., 1, 247 (1955). van Swaaij, W. P. M., J. C. Charpentier, and J. Villermaux, “Residence Time Distribution in the Liquid Phase of Trickle Flow in Packed Columns,” Chem. Eng. Sci., 24, 1,083 (1969). Citing Literature Volume32, Issue11November 1986Pages 1920-1923 ReferencesRelatedInformation
DA - 1986/11//
PY - 1986/11//
DO - 10.1002/aic.690321119
VL - 32
IS - 11
SP - 1920-1923
J2 - AIChE J.
LA - en
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SN - 0001-1541 1547-5905
UR - http://dx.doi.org/10.1002/aic.690321119
DB - Crossref
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TY - JOUR
TI - Microbiological Metal Transformations: Biotechnological Applications and Potential
AU - Olson, Gregory J.
AU - Kelly, Robert M.
T2 - Biotechnology Progress
AB - Biotechnology ProgressVolume 2, Issue 1 p. 1-15 Biotechnology Progress Topics Microbiological Metal Transformations: Biotechnological Applications and Potential Gregory J. Olson, Gregory J. Olson Surface Chemistry and Bioprocesses Group, National Bureau of Standards, Gaithersburg, MD 20899 Gregory J. Olson: is currently a research microbiologist in the Institute for Materials Science and Engineering at the National Bureau of Standards in Gaithersburg, Maryland. He received a Ph.D. in Microbiology from Montana State University in 1978 and joined NBS as a National Research Council Postdoctoral Fellow (1979–81). His current research interests include biological transformations of materials and development and application of molecular measurement methods to characterize these processes.Search for more papers by this authorRobert M. Kelly, Robert M. Kelly Department of Chemical Engineering, The Johns Hopkins University, Baltimore, MD 21218 Robert M. Kelly: is currently assistant professor of chemical engineering at the Johns Hopkins University in Baltimore, Maryland where he has been since 1981. He received his BS and MS from the University of Virginia and a Ph.D. in chemical engineering from North Carolina State University. Prior to his doctoral work, he was employed with the du Pont Company at Marshall Laboratory in Philadelphia. His research interests include separation processes, especially chemical absorption and stripping, and biochemical engineering with emphasis on engineering problems related to the growth and utilization of bacteria from extreme environments.Search for more papers by this author Gregory J. Olson, Gregory J. Olson Surface Chemistry and Bioprocesses Group, National Bureau of Standards, Gaithersburg, MD 20899 Gregory J. Olson: is currently a research microbiologist in the Institute for Materials Science and Engineering at the National Bureau of Standards in Gaithersburg, Maryland. He received a Ph.D. in Microbiology from Montana State University in 1978 and joined NBS as a National Research Council Postdoctoral Fellow (1979–81). His current research interests include biological transformations of materials and development and application of molecular measurement methods to characterize these processes.Search for more papers by this authorRobert M. Kelly, Robert M. Kelly Department of Chemical Engineering, The Johns Hopkins University, Baltimore, MD 21218 Robert M. Kelly: is currently assistant professor of chemical engineering at the Johns Hopkins University in Baltimore, Maryland where he has been since 1981. He received his BS and MS from the University of Virginia and a Ph.D. in chemical engineering from North Carolina State University. Prior to his doctoral work, he was employed with the du Pont Company at Marshall Laboratory in Philadelphia. His research interests include separation processes, especially chemical absorption and stripping, and biochemical engineering with emphasis on engineering problems related to the growth and utilization of bacteria from extreme environments.Search for more papers by this author First published: March 1986 https://doi.org/10.1002/btpr.5420020104Citations: 38 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Literature Cited 1 Torma, A. E., “Biohydrometallurgy as an emerging technology,” Biotech. Bioeng., in press. 2 Brierley, J. A., C. L. Brierley, and G. M. Goyak, “ATM—Bioclaim: A new wastewater treatment and metal recovery technology,” Proc. 6th Internat. Symp. on Biohydrometallurgy, Vancouver, BC Aug. 21–24, 1985, in press. 3 Gale, N. L. and B. G. Wixson, “Removal of heavy metals from industrial effluents by algae,” Dev. Ind. Microbiol., 20, 259 (1978). 4 Zajic, J. E., and Y. S. Chiu, “Removal of heavy metals by microbes,” Dev. Ind. Microbiol., 13, 91 (1971). 5 Temple, K. L. and A. R. Colmer, “The autotrophic oxidation of iron by a new bacterium, Thiobacillus ferrooxidans,” J. Bacteriol., 62, 605 (1951). 6 Balashava, V. I., G. E. Markosyan, and G. A. Zavarzin, “The auxotrophic growth of Leptospirillum ferrooxidans,” Microbiology, 43, 491 (1974). 7 Waksman, S. A. and J. S. Joffe, “Acid production by a new sulfur oxidizing bacterium,” Science, 53, 216 (1921). 8 Brierley, J. A., “Contribution of chemautotrophic bacteria to the acid thermal waters of the Geyser Spring Group in Yellowstone National Park,” Ph.D. thesis, Montana St. Univ., Bozeman, (1966). 9 Brock, T. D., K. M. Brock, R. T. Belly, and B. L. Weiss, “Sulfolobus: a new genus of sulfur-oxidizing bacteria living at low pH and high temperatures,” Arch. Microbiol, 84, 54 (1972). 10 Brierley, C. L. and J. A. Brierley, “A chemoautotrophic and thermophilic microorganism isolated from an acid hot spring,” Can. J. Microbiol., 19, 183 (1973). 11 Harrison, A. P. Jr., “Acidiphilium cryptum gen nov., sp. nov., heterotrophic bacterium from acidic mineral environments,” Internat. J. System. Bacteriol., 31, 327 (1981). 12 Wichlacz, P. L. and R. E. Unz, “Acidophilic heterotrophic bacteria of acid mine wastes,” Appl. Environ. Microbiol., 41, 1254 (1981). 13 Brierley, J. A., “Thermophilic iron-oxidizing bacteria found in copper leach dumps,” Appl. Environ. Microbiol., 36, 523 (1978). 14 Wood, A. P. and D. P. Kelly, “Autotrophic and mixotrophic growth of three thermoacidophilic iron-oxidizing bacteria,” Trends in Biotechnol., 3, 86 (1985). 15 Gentina, J. C. and F. Acevedo, “Microbial ore leaching in developing countries,” Trends in Biotechnol, 3, 86 (1985). 16 Ehrlich, H. L., “Inorganic energy sources for chemolithotrophic and mixotropic bacteria,” Geomicrobiol. J., 1, 65 (1978). 17 Lewis, A. J., and J. D. A. Mier, “Stannous and cuprous ion oxidation by Thiobacillus ferrooxidans,” Can. J. Microbiol., 23, 319 (1977). 18 DiSpirito, A. A. and O. H. Tuovinen, “Uranous ion oxidation and carbon dioxide fixation by Thiobacillus ferrooxidans,” Arch. Microbiol., 133, 28 (1982). 19 Kelly, D. P., Bioenergetics of chemolithotrophic bacteria, Chap. 15 in Companion to Microbiology, A. T. Bull and P. M. Meadows, eds., Longman: London and New York, pp. 363–386 (1978). 20 Ingledew, W. J., “Thiobacillus ferrooxidans: The bioenergetics of an acidophilic chemolithotroph,” Biochim. Biophys. 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DA - 1986/3//
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IS - 1
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LA - en
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UR - http://dx.doi.org/10.1002/btpr.5420020104
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DA - 1986/3//
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IS - 5
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DA - 1986/4//
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IS - 8
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DA - 1986/5//
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IS - 9
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DA - 1986///
PY - 1986///
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DA - 1986///
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DA - 1986///
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T2 - Veterinary and Human Toxicology
DA - 1986///
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PB - Pan American Health Organization
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AU - Moye, David W.
AU - Hawkins, Jess H.
T2 - Mycologia
AB - Aphanomyces and Saprolegnia were isolated from characteristic lesions of Ulcerative Mycosis (UM) on Atlantic menhaden and other fish. One of the Aphanomyces isolates was selected for cultural studies which revealed that the fungus was stimulated to increased vegetative growth and improved zoosporulation by low levels of NaCl. The salt tolerance exhibited by this fungus surpassed the known recorded limits for Oomycetes in regard to zoosporogenesis. The relationship of the fungal isolates to the lesions found on fish and the association of prevailing climatological conditions with the disease suggest a complex interaction between the fungus, possibly pre-stressed fish, and the salinity of the estuary systems of North Carolina.
DA - 1986/7//
PY - 1986/7//
DO - 10.1080/00275514.1986.12025303
VL - 78
IS - 4
SP - 664-672
J2 - Mycologia
LA - en
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UR - http://dx.doi.org/10.1080/00275514.1986.12025303
DB - Crossref
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TI - Nasal Rhinosporidiosis in the Dog
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AU - Dykstra, M. J.
AU - Breitschwerdt, E. B.
AU - Holzinger, E. A.
AU - Cattley, R. C.
T2 - Veterinary Pathology
AB - Rhinosporidiosis was diagnosed in six dogs from the southeastern United States. All six dogs had unilateral nasal polyps with multiple small white sporangia visible beneath the surface. Microscopically, the polyps consisted of organisms and fibrovascular tissue with a surface of columnar or squamous epithelium. Juvenile sporangia were unilamellar, 15-75 microns in diameter, nucleated, and accounted for about 65% of sporangia seen. Approximately 5% of the sporangia were in intermediate stages of maturation, were bilamellar, 100-150 microns in diameter, and contained immature endospores. Mature sporangia comprised about 30% of the total, were usually unilamellar, 100-400 microns in diameter, and contained a mixture of immature and mature endospores. The inner layer of the wall of the intermediate sporangia and the single wall of the mature sporangia were argyrophilic and carminophilic. Ultrastructurally, the earliest stage contained a nucleus and many ribosomes, lipid droplets, and phagolysosomes. Maturing sporangia contained discrete membrane-bound, round clevage products. These structures subsequently matured to spores, each of which had a wall and contained a nucleus and many lipid droplets. The organism from one dog was cultured and grown in vitro for 7 months and is the first successful cultivation of Rhinosporidium seeberi.
DA - 1986/1//
PY - 1986/1//
DO - 10.1177/030098588602300108
VL - 23
IS - 1
SP - 50-56
J2 - Vet Pathol
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UR - http://dx.doi.org/10.1177/030098588602300108
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TI - Effects of Type of Cage Partition, Cage Shape, and Bird Density on Productivity and Well-Being of Layers
AU - Ramos, N.C.
AU - Anderson, K.E.
AU - Adams, A.W.
T2 - Poultry Science
AB - In Experiment 1 there were no significant differences in rate of lay, egg quality, latency to feeding, and feather condition of hens in cages with wire mesh or solid metal side partitions. Birds in cages with solid metal side partitions had significantly higher mortality (6%) and weight gain (6%) than those in cages with wire side partitions. The deep caged hens had significantly lower mortality (8%) than the shallow caged hens. Hens housed at 464 cm2 of floor area/hen had significantly higher hen-housed egg production (4.9%), lower weight gain (8%), and higher average feather scores (. 8 unit) than those housed at 348 cm2. In Experiment 2 type of cage side and back partitions (wire vs. solid metal) significantly affected grams of egg per gram of feed. Birds in deep cages had significantly lower mortality (8.6%) and higher feed consumption (15.2 g/hen/day) than those in shallow cages. Hen-housed rate of lay, mortality, weight gain, feed conversion, and feather scores were significantly affected by bird density: 64.6%, 15%, 24.6%, .384% g egg/g feed, and 4.7 units, respectively, for hens with 464 cm2 floor area vs. 70.8%, 8.3%, 25.2%, .362% g egg/g feed, and 5.8 units for hens with 348 cm2. Data suggest that hens in cages with solid metal sides performed similarly to their sisters in cages with wire mesh sides and backs.
DA - 1986/11//
PY - 1986/11//
DO - 10.3382/ps.0652023
VL - 65
IS - 11
SP - 2023-2028
J2 - Poultry Science
LA - en
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SN - 0032-5791
UR - http://dx.doi.org/10.3382/ps.0652023
DB - Crossref
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TY - JOUR
TI - Cultivation of Rhinosporidium seeberi in vitro: interaction with epithelial cells
AU - Levy, M.
AU - Meuten, D.
AU - Breitschwerdt, E.
T2 - Science
AB - Rhinosporidium seeberi, a fungus that is associated with polyp-like tumors in animals and man, was successfully cultivated. This organism stimulated proliferation of epithelial cells in vitro, producing polyp-like structures. Spores produced in culture required a period of aging or development, or both, before they were capable of reinitiating the growth cycle.
DA - 1986/10/24/
PY - 1986/10/24/
DO - 10.1126/science.3764422
VL - 234
IS - 4775
SP - 474-476
J2 - Science
LA - en
OP -
SN - 0036-8075 1095-9203
UR - http://dx.doi.org/10.1126/science.3764422
DB - Crossref
ER -
TY - JOUR
TI - Diagnosis of Canine Viral Infections
AU - Guy, James S.
T2 - Veterinary Clinics of North America: Small Animal Practice
AB - Canine viral infections may be tentatively diagnosed on the basis of clinical signs, hematologic findings, and/or gross pathology; however, definitive diagnosis generally requires laboratory assistance. Laboratory diagnosis of these infections relies on one or more of the following procedures: histopathology, virus isolation, serology, and the detection of virus, or viral antigens, using electron microscopy, fluorescent antibody techniques, immunoperoxidase techniques, and enzyme immunosorbent assays.
DA - 1986/11//
PY - 1986/11//
DO - 10.1016/s0195-5616(86)50133-9
VL - 16
IS - 6
SP - 1145-1156
J2 - Veterinary Clinics of North America: Small Animal Practice
LA - en
OP -
SN - 0195-5616
UR - http://dx.doi.org/10.1016/s0195-5616(86)50133-9
DB - Crossref
ER -
TY - JOUR
TI - Intestinal Cryptosporidiosis and Reovirus Isolation from Bobwhite Quail (Colinus virginianus) with Enteritis
AU - Ritter, G. Donald
AU - Ley, D. H.
AU - Levy, M.
AU - Guy, J.
AU - Barnes, H. John
T2 - Avian Diseases
AB - An acute enteric disease of young pen-raised bobwhite quails was studied. Affected quails had white, watery diarrhea accompanied by dehydration and subsequent death. Mortality from hatch to 17 days of age ranged from 30 to 45% in the three flocks examined. Small intestines were thin-walled and distended with fluid and gas. Microscopic lesions in the intestinal tract consisted of villus atrophy, villus fusion, and sloughing of cells at the tip of the villi in duodenum, jejunum, and ileum. Cryptosporidium sp. and reovirus were identified in affected quails.
DA - 1986/7//
PY - 1986/7//
DO - 10.2307/1590430
VL - 30
IS - 3
SP - 603
J2 - Avian Diseases
OP -
SN - 0005-2086
UR - http://dx.doi.org/10.2307/1590430
DB - Crossref
ER -
TY - JOUR
TI - Effect of nutritional status, age at weaning and room temperature on growth and systemic immune response of weanling pigs.
AU - Crenshaw, T.D.
AU - Cook, M.E.
AU - Odle, J.
AU - Martin, R.E.
T2 - Journal of animal science
DA - 1986///
PY - 1986///
VL - 63
IS - 6
SP - 1845-1853
UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-0023015344&partnerID=MN8TOARS
ER -
TY - JOUR
TI - Use of monoclonal antibodies to identify four neutralization immunogens on a common cold picornavirus, human rhinovirus 14
AU - Sherry, B.
AU - Mosser, A.G.
AU - Colonno, R.J.
AU - Rueckert, R.R.
T2 - Journal of Virology
C2 - 252721
DA - 1986///
PY - 1986///
VL - 57
IS - 1
SP - 246–257
ER -
TY - JOUR
TI - Equation of state for athermal lattice chains
AU - Dickman, Ronald
AU - Hall, Carol K.
T2 - The Journal of Chemical Physics
AB - We report results of Monte Carlo simulations of athermal chains in the square lattice, and present a detailed comparison between Flory and Flory–Huggins theories and the numerical results.
DA - 1986/9//
PY - 1986/9//
DO - 10.1063/1.451010
VL - 85
IS - 5
SP - 3023-3026
J2 - The Journal of Chemical Physics
LA - en
OP -
SN - 0021-9606 1089-7690
UR - http://dx.doi.org/10.1063/1.451010
DB - Crossref
ER -
TY - JOUR
TI - Elastic interactions between hydrogen atoms in metals. II. Elastic interaction energies
AU - Shirley, Arthur I.
AU - Hall, Carol K.
T2 - Physical Review B
AB - The fully harmonic lattice approximation derived in a previous paper is used to calculate the elastic interaction energies in the niobium-hydrogen system. The permanent-direct, permanent-indirect, induced-direct, and induced-indirect forces calculated previously each give rise to a corresponding elastic interaction between hydrogen atoms. The latter three interactions have three- and four-body terms in addition to the usual two-body terms. These quantities are calculated and compared with the corresponding two-body permanent elastic interactions obtained in the harmonic-approximation treatment of Horner and Wagner. The results show that the total induced elastic energy is approximately (1/3) the size of the total permanent elastic energy and opposite to it in sign. The total elastic energy due to three-body interactions is approximately (1/4) the size of the total two-body elastic energy, while the total four-body elastic energy is approximately 5% of the total two-body energy. These additional elastic energies are expected to have a profound effect on the thermodynamic and phase-change behavior of a metal hydride.
DA - 1986/6/15/
PY - 1986/6/15/
DO - 10.1103/physrevb.33.8099
VL - 33
IS - 12
SP - 8099-8109
J2 - Phys. Rev. B
LA - en
OP -
SN - 0163-1829
UR - http://dx.doi.org/10.1103/physrevb.33.8099
DB - Crossref
ER -
TY - JOUR
TI - Elastic interactions between hydrogen atoms in metals. I. Lattice forces and displacements
AU - Shirley, Arthur I.
AU - Hall, Carol K.
T2 - Physical Review B
AB - This is the first of a series of papers in which a second-order perturbation theory is derived for the Hamiltonian of a metal hydride. The theory, which is called the fully harmonic lattice approximation, or FHLA, goes beyond the customary harmonic treatment of Horner and Wagner to include second-order terms for the hydrogen-hydrogen and metal-hydrogen potentials. These terms account for the hydrogen-concentration dependences of a metal hydride's volume and elastic constants; their inclusion should result in a better representation of the free-energy and phase-change behavior at high hydrogen concentration. In this paper, the forces between hydrogen atoms and metal atoms are evaluated using the FHLA. Two types of forces result: direct forces, between an isolated hydrogen atom and a metal atom, and indirect forces, which are effective forces between a hydrogen atom and a metal atom caused by the presence of a neighboring hydrogen atom. Both the direct and indirect forces each have two components: a permanent part, which is equivalent to the force exerted by a hydrogen atom on a metal atom in the pure (hydrogen-free) metal lattice, and an induced part, which corrects the permanent part for the effects of the hydrogen atom on the metal-metal couplings. These four forces are evaluated for the hydrogen-niobium system. The indirect forces have one-tenth the magnitude and are of opposite sign to the direct forces. The induced component of the force is approximately one-third the size of the permanent component, and opposite to it in sign. The displacements of the metal atoms surrounding an isolated hydrogen atom or a pair of hydrogen atoms are also evaluated. These are compared with the results of previous harmonic-approximation calculations and of experiments on the hydrogen-niobium system. In a subsequent paper these forces are used to evaluate the elastic interaction of hydrogen atoms in a metal.
DA - 1986/6/15/
PY - 1986/6/15/
DO - 10.1103/physrevb.33.8084
VL - 33
IS - 12
SP - 8084-8098
J2 - Phys. Rev. B
LA - en
OP -
SN - 0163-1829
UR - http://dx.doi.org/10.1103/physrevb.33.8084
DB - Crossref
ER -
TY - JOUR
TI - Mathematical modelling of diffusion and reaction in blocked zeolite catalysts
AU - Sundaresan, S.
AU - Hall, C.K.
T2 - Chemical Engineering Science
AB - A mathematical model for diffusion and reaction in blocked zeolites is developed which takes into account nonidealities arising from interaction between sorbed molecules as well as the effect of pore and surface blocking. The model combines a microscopic approach, in which expressions for chemical potential and diffusive fluxes are calculated within the lattice-gas framework, with the more traditional continuum approach which takes into account the effect of surface blocking. The effect of pore blocking on the diffusive fluxes in accounted for through an effective medium approximation. The effects of crystal size and blocking on the activity-selectivity characteristics of the crystal are illustrated through an example that is qualitatively similar to industrially important reactions such as alkylation of toluene in blocked ZSM-5 zeolite.
DA - 1986///
PY - 1986///
DO - 10.1016/0009-2509(86)85242-3
VL - 41
IS - 6
SP - 1631-1645
J2 - Chemical Engineering Science
LA - en
OP -
SN - 0009-2509
UR - http://dx.doi.org/10.1016/0009-2509(86)85242-3
DB - Crossref
ER -
TY - CHAP
TI - Local Structure of Fluids Containing Short-Chain Molecules via Monte Carlo Simulation
AU - Honnell, K. G.
AU - Hall, C. K.
T2 - Equations of State
AB - Monte Carlo simulation has been used to investigate local structure of model systems of butane and octane at volume fractions ranging from 0.001 to 0.3. At low and moderate densities the bead-bead intermolecular radial distribution function, g(r), near contact was found to be significantly less than one, indicating the presence of an excluded volume surrounding each bead. The value of g(r) near contact increased with increased density, and decreased with increased chain length.
PY - 1986/3/24/
DO - 10.1021/bk-1986-0300.ch009
SP - 201-213
OP -
PB - American Chemical Society
SN - 0841209588 0841211329
UR - http://dx.doi.org/10.1021/bk-1986-0300.ch009
DB - Crossref
ER -
TY - JOUR
TI - An experimental and theoretical study of phase transitions in the polystyrene latex and hydroxyethylcellulose system
AU - Gast, A.P
AU - Russel, W.B
AU - Hall, C.K
T2 - Journal of Colloid and Interface Science
AB - We present an experimental study of phase transitions induced in polystyrene latices by hydroxyethylcellulose and interpret the results by applying perturbation theory from statistical mechanics to an interaction potential derived from the volume exclusion mechanism of Akasura and Oosawa. The predictions agree semiquantitatively with the measured colloidal phase densities and the critical polymer concentration above which flocculation occurs for a wide range of ionic strengths. The theory also predicts the type of phase transition, i.e., fluid-solid or fluid-fluid, observed by Sperry. The agreement between experiment and theory demonstrates the predictive capability of the perturbation theory for weakly aggregating colloidal suspensions.
DA - 1986/1//
PY - 1986/1//
DO - 10.1016/0021-9797(86)90291-2
VL - 109
IS - 1
SP - 161-171
J2 - Journal of Colloid and Interface Science
LA - en
OP -
SN - 0021-9797
UR - http://dx.doi.org/10.1016/0021-9797(86)90291-2
DB - Crossref
ER -
TY - JOUR
TI - Theory of the order–disorder transition in hydrogen–niobium systems
AU - Futran, Mauricio
AU - Hall, Carol K.
T2 - The Journal of Chemical Physics
AB - A theoretical investigation of the high temperature phase change behavior of hydrogen in niobium is described. In an effort to understand the interplay between the hydrogen–hydrogen interactions considered and the appearance of the α, α′, β, and ε phases, a series of lattice-gas model calculations of the phase diagram is performed. It is shown that the pairwise interactions at the first three shells beyond the hard core must satisfy certain constraints in order to obtain the α→α′→β sequence of phases at high temperatures. A set of interactions which gives the best predictions for the α–α′–β phase boundary is described. It does not appear possible to produce a set of pairwise interactions of range <21/2a which simultaneously yields the α, α′, β, and ε phases. This indicates that multibody interactions are of nonnegligible significance at higher hydrogen concentrations.
DA - 1986/8//
PY - 1986/8//
DO - 10.1063/1.451194
VL - 85
IS - 3
SP - 1539-1544
J2 - The Journal of Chemical Physics
LA - en
OP -
SN - 0021-9606 1089-7690
UR - http://dx.doi.org/10.1063/1.451194
DB - Crossref
ER -
TY - CONF
TI - Research on new barrier testing approaches
AU - McCord, M.G.
A2 - R. L. Barker,
A2 - Coletta, G. C.
C2 - 1986///
C3 - Performance of protective clothing: a symposium sponsored by ASTM Committee F-23 on Protective Clothing, Raleigh, NC, 16-20 July 1984
DA - 1986///
PB - Philadelphia, PA: ASTM
SN - 9780803104617
ER -
TY - CONF
TI - Introduction to testing of chemical and biological barriers
AU - McCord, M.G.
A2 - R. L. Barker,
A2 - Coletta, G. C.
C2 - 1986///
C3 - Performance of protective clothing: a symposium sponsored by ASTM Committee F-23 on Protective Clothing, Raleigh, NC, 16-20 July 1984
DA - 1986///
PB - Philadelphia, PA: ASTM
SN - 9780803104617
ER -
TY - JOUR
TI - TIME COURSE FOR PROSTAGLANDIN SYNTHESIS BY RABBIT LENS DURING ENDOTOXIN-INDUCED OCULAR INFLAMMATION
AU - FLEISHER, LN
AU - MCGAHAN, MC
T2 - CURRENT EYE RESEARCH
AB - AbstractThree hours to 14 days following the intravitreal injection of 10 ng of E. coli endotoxin into the vitreal chamber of one eye of the New Zealand white rabbit, ocular inflammation was evaluated by clinical and biochemical criteria and prostaglandins were measured in the intraocular fluids and in the incubation medium of the intact lens. Increased synthesis of PGE2 was detected for lenses from inflamed eyes beginning at 18 h post-endotoxin injection. Lenticular PGE2 synthesis remained above control levels for the duration of the time course. Lenses also exhibited increased PGF2α synthesis, which began at 18 h and returned to control levels by day 7. At the times of peak production, aqueous humor PGE2 concentration correlated with lenticular PGE2 synthesis and with aqueous humor leukocyte number. No correlations were found for lenticular PGE2 vs. cell number, or vitreous humor PGE2 vs. aqueous humor PGE2. These results suggest that during ocular inflammation, aqueous humor PGE2 may be derived, at least in part, from the lens and leukocytes.
DA - 1986/9//
PY - 1986/9//
DO - 10.3109/02713688609015129
VL - 5
IS - 9
SP - 629-634
SN - 0271-3683
ER -
TY - JOUR
TI - THE PATHOPHYSIOLOGY OF THE OCULAR MICROENVIRONMENT .2. COPPER-INDUCED OCULAR INFLAMMATION AND HYPOTONY
AU - MCGAHAN, MC
AU - BITO, LZ
AU - MYERS, BM
T2 - EXPERIMENTAL EYE RESEARCH
AB - The ocular effects of intravitreally injected copper sulfate solutions were studied in New Zealand white rabbits. These injections resulted in uveitis characterized by prolonged ocular hypotony, increased protein concentrations and decreased ascorbic acid concentrations in both the vitreous and aqueous humors, and an apparent decrease in the transport function of the anterior uvea. The extent and the duration of these effects were dose-dependent. The lower doses used, 3 or 6 micrograms of Cu as CuSO4 per eye, produced reversible inflammation. The highest dose, 30 micrograms of Cu per eye, also produced some signs of ocular chalcosis: hemorrhage, vitreous liquefaction, prolonged hypotony and local iridial ischemia. Six hours after the intravitreal injection of 6 micrograms of Cu as CuSO4 per eye, the Cu concentration in the vitreous humor increased to approximately 100 times that in the vitreous of control eyes, and began to decline only 3 days later, with a half-time of approximately 8 days. The Cu concentration in the anterior chamber of these eyes never exceeded 1 ppm and returned close to control values within 3 days. Based on these findings, factors that affect ocular trace-metal distribution and kinetics are discussed, as are reasons for the apparent difficulty in diagnosing the presence of Cu-containing intraocular foreign bodies on the basis of the Cu concentration of the aqueous humor.
DA - 1986/6//
PY - 1986/6//
DO - 10.1016/0014-4835(86)90049-7
VL - 42
IS - 6
SP - 595-605
SN - 0014-4835
ER -
TY - JOUR
TI - Effects of melittin on a model renal epithelium, the toad urinary bladder
AU - McGahan, M. C.
AU - Matthews, D. O.
AU - Bentley, P. J.
T2 - Biochimica et Biophysica Acta
AB - The bee venom melittin, 10(-6) M, on the mucosal (urinary) side of the toad urinary bladder (in vitro), markedly decreased transepithelial potential difference, short-circuit current (Isc, sodium-dependent) and resistance. However, these effects were not seen when the toxin was placed on the opposite (serosal) side of the membrane preparation. The electrical effects were accompanied by a large increase in the transepithelial permeability to 22Na. The response was not changed by meclofenamic acid (which blocks formation of prostaglandins) but it was inhibited by La3+. In the presence of amiloride, which usually inhibits active Na transport and Isc, melittin, on the mucosal side, increased the Isc. The action of melittin appears to involve an interaction with anionic sites, which mediate its effects. Such sites appear to be present on the apical plasma membranes of the toad bladder epithelial cells, but they are not as abundant or they are inaccessible on the basal plasma membrane.
DA - 1986///
PY - 1986///
DO - 10.1016/0005-2736(86)90189-6
VL - 855
SP - 63-67
ER -
TY - JOUR
TI - ANTIOXIDANT ACTIVITY OF AQUEOUS AND VITREOUS-HUMOR FROM THE INFLAMED RABBIT EYE
AU - MCGAHAN, MC
AU - FLEISHER, LN
T2 - CURRENT EYE RESEARCH
AB - The effects of aqueous and vitreous humors and plasma on the rate of auto-oxidation of a rabbit brain homogenate were measured. Both aqueous and vitreous humors from normal eyes increased, while plasma decreased the rate of oxidation in the homogenate. During endotoxin-induced ocular inflammation the copper (Cu) and iron (Fe) concentrations of both the aqueous and vitreous humors increased, most likely due to the influx of their plasma binding proteins, ceruloplasmin (Cu) and transferrin (Fe). As both proteins are known to be antioxidants, it was not surprising to find that the aqueous and vitreous humor from the inflamed eyes had significant antioxidant activity. This antioxidant activity correlated well with the concentrations of Cu and Fe in aqueous humor and Cu but not Fe in the vitreous humor throughout the time course of the inflammatory response. Thus, entry of plasma proteins through disrupted blood ocular barriers may function in protecting ocular tissues against the increased oxidation which occurs during inflammation.
DA - 1986/9//
PY - 1986/9//
DO - 10.3109/02713688609015131
VL - 5
IS - 9
SP - 641-645
SN - 0271-3683
ER -
TY - JOUR
TI - A MICROMETHOD FOR THE DETERMINATION OF IRON AND TOTAL IRON-BINDING-CAPACITY IN INTRAOCULAR FLUIDS AND PLASMA USING ELECTROTHERMAL ATOMIC-ABSORPTION SPECTROSCOPY
AU - MCGAHAN, MC
AU - FLEISHER, LN
T2 - ANALYTICAL BIOCHEMISTRY
AB - A new micromethod (requiring only 30 microliters of sample) for the determination of iron (Fe) concentration and total iron-binding capacity (TIBC) in intraocular fluids (IOFs; aqueous and vitreous humors) and plasma has been developed using electrothermal atomic absorption spectrophotometry. Values for Fe concentration in the IOFs were similar between species and were generally higher in the vitreous (0.031-0.060 mg/liter) than aqueous (0.014-0.038 mg/liter) humors obtained from the same eye. Plasma Fe concentration and TIBC fell within established limits for all species studied. The iron binding capacity of the aqueous and vitreous humors from the same species is similar. While the TIBC of the aqueous humor is saturated to the same extent as plasma, vitreous TIBC is more highly saturated in all species. Using this method considerably less species variation in IOF Fe concentration was found as compared to previous studies. Some possible methodological reasons for this difference are discussed.
DA - 1986/8/1/
PY - 1986/8/1/
DO - 10.1016/0003-2697(86)90271-X
VL - 156
IS - 2
SP - 397-402
SN - 0003-2697
ER -
TY - JOUR
TI - Effect of hyperthermia on cisplatin pharmacokinetics in normal dogs
AU - Riviere, J. E.
AU - Page, R. L.
AU - Dewhirst, M. W.
AU - Tyczkowska, K.
AU - Thrall, D. E.
T2 - International Journal of Hyperthermia
AB - In vitro and in vivo cisplatin pharmacokinetic studies were conducted at 37°C and 42–43°C in dogs. Cisplatin at 1, 2, 3, 4 and 5 μg/ml was incubated with canine serum at 37° and 43°C. Aliquots were processed immediately for atomic absorption spectrophotometry to determine total as well as free, ultrafilterable cisplatin concentrations. Thirteen healthy, average-sized mongrel dogs received 1 mg/kg cisplatin as an intravenous bolus. Four were maintained unanaesthetized at 37°C, two were anaesthetized and maintained at 37°C and seven were anaesthetized and maintained at a rectal temperature of 42°C for 60 min. Serum samples were obtained and processed for free and total cisplatin.There were no detectable concentration effects present in either in vitro group. The rate constant reflecting the decay of free cisplatin at 37°C was 0.0035 ± 0.0007 min-1 and increased significantly (P< 0 0001) to 0.0053 ± 0.001 min-1 at 43°C. In vivo pharmacokinetic analysis consisted of model-independent parameters (total body clearance, volume of distribution, half-life and mean residence time). A significant increase (P≤0.05) in all parameters was observed with free-cisplatin at 42°C.This data would indicate that at the elevated temperatures encountered in whole body hyperthermia, the rate of formation of reactive metabolites from parent cisplatin is increased. The increased clearance rate at 42°C of ultrafilterable cisplatin is consistent with increased renal clearance, increased biotransformation, or increased rate of tissue binding. The increased volume of distribution of free cisplation is most compatible with enhanced tissue extraction at 42°C. However, further studies are indicated.
DA - 1986///
PY - 1986///
DO - 10.3109/02656738609004965
VL - 2
SP - 351-358
ER -
TY - JOUR
TI - COPPER CONCENTRATION IN CORNEA, IRIS, NORMAL, AND CATARACTOUS LENSES AND INTRAOCULAR FLUIDS OF VERTEBRATES
AU - COOK, CS
AU - MCGAHAN, MC
T2 - CURRENT EYE RESEARCH
AB - A method using electrothermal atomic absorption spectroscopy was developed for the determination of copper (Cu) concentration in the cornea, iris, and lens of a variety of species, including dog, cat, rabbit, horse, and toad. Previously described methods were used to determine Cu in aqueous and vitreous humor. There was little difference between copper levels in the same tissue or fluid across the species. However, there were age and pathology-related changes in Cu concentration of the aqueous humor, cornea, and lens. In the groups of older dogs, the Cu concentration of the aqueous humor and cornea is significantly lower than the two younger groups. In both the dog and rabbit, lenses from young animals have the lowest copper concentration which increases and then finally decreases with age. Canine hypermature cataracts have a significantly higher copper concentration than control dogs of all age groups. There was no correlation between Cu concentration in the intraocular fluids and the cataractous lenses taken from the same eye. The role such an increase in lenticular Cu concentration may play in cataractogenesis needs to be explored.
DA - 1986/1//
PY - 1986/1//
DO - 10.3109/02713688608995168
VL - 5
IS - 1
SP - 69-76
SN - 0271-3683
ER -
TY - JOUR
TI - Longitudinal Assessment of the Clinical and Epidemiological Features of Lyme Disease in a Defined Population
AU - Steere, A. C.
AU - Taylor, E.
AU - Wilson, M. L.
AU - Levine, J. F.
AU - Spielman, A.
T2 - Journal of Infectious Diseases
AB - From 1979 to 1983, Lyme disease was studied longitudinally in the 162 long-term residents of Great Island, Massachusetts. In retrospect, the index case occurred in 1962, and the peak years of disease transmission (about three new cases per 100 residents per year) were the late 1970s. Thereafter, during the period of active surveillance, attack rates declined by half. Altogether, 26 (16%) of the 162 residents developed symptoms of the disease. Most of those affected had erythema chronicum migrans, and when untreated, they subsequently developed arthritis or, in one instance, myocarditis. A minority of individuals, mostly children, had arthritis alone. Of 121 asymptomatic residents who gave blood samples, 10 adults (8%) had high titers of IgG antibodies to the Lyme disease spirochete; these titers sometimes persisted for years. From 1981 to 1983, the estimated ratio of apparent-to-inapparent infection was 1:1. The high frequency of Lyme disease on Great Island underscores the need for surveillance and control programs.
DA - 1986/8/1/
PY - 1986/8/1/
DO - 10.1093/infdis/154.2.295
VL - 154
IS - 2
SP - 295-300
J2 - Journal of Infectious Diseases
LA - en
OP -
SN - 0022-1899 1537-6613
UR - http://dx.doi.org/10.1093/infdis/154.2.295
DB - Crossref
ER -
TY - JOUR
TI - Comparative prevalence of Babesia microti and Borrelia burgdorferi in 4 populations of Ixodes dammini in Eastern Massachusetts
AU - Piesman, J.
AU - Mather, T. S.
AU - Donohue, J.
AU - Levine, J. F.
AU - Campbell, J.
AU - Karakashian, K.
AU - Spielman, A.
T2 - Acta Tropica
DA - 1986///
PY - 1986///
VL - 43
SP - 263-270
ER -
TY - JOUR
TI - CHARACTERIZATION OF THE APHANOMYCES SPECIES INVOLVED WITH ULCERATIVE MYCOSIS (UM) IN MENHADEN
AU - DYKSTRA, MJ
AU - NOGA, EJ
AU - LEVINE, JF
AU - MOYE, DW
AU - HAWKINS, JH
T2 - MYCOLOGIA
AB - Aphanomyces and Saprolegnia were isolated from characteristic lesions of Ulcerative Mycosis (UM) on Atlantic menhaden and other fish. One of the Aphanomyces isolates was selected for cultural studies which revealed that the fungus was stimulated to increased vegetative growth and improved zoosporulation by low levels of NaCl. The salt tolerance exhibited by this fungus surpassed the known recorded limits for Oomycetes in regard to zoosporogenesis. The relationship of the fungal isolates to the lesions found on fish and the association of prevailing climatological conditions with the disease suggest a complex interaction between the fungus, possibly pre-stressed fish, and the salinity of the estuary systems of North Carolina.
DA - 1986///
PY - 1986///
DO - 10.2307/3807780
VL - 78
IS - 4
SP - 664-672
SN - 0027-5514
ER -
TY - CHAP
TI - Intracellular translocation of inorganic particles.
AU - Brody, A. R.
AU - Hill, L. H.
AU - Hesterberg, T. W.
AU - Barrett, J. C.
AU - Adler, K. B.
T2 - The cytoskeleton.
PY - 1986///
DO - 10.1007/978-1-4613-2161-3_17
SP - 221-227
ER -
TY - JOUR
TI - Alterations in the cellular population of the alveolar wall in an animal model of fibrosis: a morphometric study.
AU - Callahan, L. M.
AU - Evans, J. N.
AU - Adler, K. B.
T2 - Chest
DA - 1986///
PY - 1986///
VL - 89
SP - 189S-190
ER -
TY - JOUR
TI - Alterations in the cellular population of the alveolar wall in bleomycin induced pulmonary fibrosis in rats: an ultrastructural morphometric study.
AU - Adler, K. B.
AU - Callahan, L. M.
AU - Evans, J. N.
T2 - American Review of Respiratory Disease
DA - 1986///
PY - 1986///
VL - 133
SP - 1043-1048
ER -
TY - JOUR
TI - Platelet activating factor stimulates secretion of mucin by explants of rodent airways in organ culture.
AU - Adler, K. B.
AU - Schwarz, J. E.
AU - Anderson, W. H.
AU - Welton, A. F.
T2 - American Review of Respiratory Disease
DA - 1986///
PY - 1986///
VL - 133
SP - A212
ER -
TY - CHAP
TI - Oxygen free radicals stimulate secretion of mucin by rodent respiratory epithelium in vitro.
AU - Adler, K. B.
AU - Schwarz, J. E.
AU - Repine, J. E.
T2 - Microbeam analysis -- 1986.
PY - 1986///
SP - 571-573
ER -
TY - CHAP
TI - Mucin secretion by respiratory tract tissue in vitro.
AU - Adler, K. B.
T2 - In vitro models of respiratory epithelium
PY - 1986///
SP - 27-50
ER -
TY - JOUR
TI - Mechanisms of asbestos induced toxicity and lung disease.
AU - Mossman, B. T.
AU - Adler, K. B.
T2 - In Vitro Cellular & Developmental Biology. Animal
DA - 1986///
PY - 1986///
VL - 22
SP - 49A
ER -
TY - JOUR
TI - Effects of hyperoxia on metabolism of arachidonic acid by pulmonary vessels and airways.
AU - Coflesky, J. T.
AU - Adler, K. B.
AU - Anderson, W. H.
AU - Evans, J. N.
T2 - In Vitro Cellular & Developmental Biology. Animal
DA - 1986///
PY - 1986///
VL - 22
SP - 44A
ER -
TY - JOUR
TI - Bacteria associated with chronic obstructive pulmonary disease elaborate extracellular products that stimulate secretion of mucin by explants of guinea pig airways.
AU - Adler, K. B.
AU - Hendley, D. D.
AU - Davis, G. S.
T2 - American Journal of Pathology
DA - 1986///
PY - 1986///
VL - 125
SP - 501-514
ER -
TY - JOUR
TI - A new chamber system for maintaining differentiated guinea pig respiratory epithelial cells between air and liquid phases.
AU - Adler, K. B.
AU - Whitcutt, J. M.
AU - Wu, R.
T2 - Journal of Cell Biology
DA - 1986///
PY - 1986///
VL - 103
SP - 207a
ER -
TY - JOUR
TI - A cyclooxygenase product of arachidonic acid is involved in epithelium mediated modulation of rabbit airway smooth muscle responsiveness.
AU - Szarek, J. L.
AU - Buter, G. B.
AU - Adler, K. B.
AU - Evans, J. N.
T2 - American Review of Respiratory Disease
DA - 1986///
PY - 1986///
VL - 133
SP - A115
ER -
TY - JOUR
TI - Recombinant DNA, gene transfer and the future of animal agriculture
AU - Petters, R. M.
T2 - Journal of Animal Science
DA - 1986///
PY - 1986///
VL - 62
IS - 6
SP - 1759
ER -
TY - JOUR
TI - EQUATION OF STATE FOR CHAIN MOLECULES - CONTINUOUS-SPACE ANALOG OF FLORY THEORY
AU - DICKMAN, R
AU - HALL, CK
T2 - JOURNAL OF CHEMICAL PHYSICS
AB - New, accurate equations of state for fluids of chain molecules are derived as generalizations of the well-known Flory and Flory–Huggins lattice theories to continuous space. Comparison with the results of new Monte Carlo simulations of athermal chains (freely jointed hard disks and spheres), extending over a wide range of densities, reveals that the generalized Flory–Huggins equation of state provides an accurate prediction for the pressure.
DA - 1986/10/1/
PY - 1986/10/1/
DO - 10.1063/1.450881
VL - 85
IS - 7
SP - 4108-4115
SN - 0021-9606
ER -