Works Published in 2020
Displaying works 261 - 280 of 779 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2020 review
Classification of Intervertebral Disc Disease
[Review of ]. FRONTIERS IN VETERINARY SCIENCE, 7.
author keywords: IVD; chondrodystrophy; degeneration; Hansen; extrusion; protrusion
TL;DR:
An up to date overview of both historical and current systems of IVDD classification is provided, highlighting the important findings and controversies underpinning them.
(via Semantic Scholar)
www.frontiersin.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: November 9, 2020
2020 journal article
Color-Variable Photodynamic Antimicrobial Wool/Acrylic Blended Fabrics
Materials, 13(18), 4141.
author keywords: antibacterial; photodynamic; apparent color; blended fabric; photosensitizer; rose bengal; cationic dyes; wool; acrylic
TL;DR:
Overall, the findings demonstrate the feasibility and potential applications of low cost and color variable RB-loaded W/A blended fabrics as effective self-disinfecting textiles against pathogen transmission.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, Crossref
Added: November 9, 2020
2020 journal article
Comprehensive phenotypic and genotypic characterization and comparison of virulence, biofilm, and antimicrobial resistance in urinary Escherichia coli isolated from canines
VETERINARY MICROBIOLOGY, 249.
author keywords: Biofilm; Urinary tract infections; Canine; Uropathogenic; Escherichia coli; Antimicrobial resistance
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Biofilms / drug effects; Dog Diseases / microbiology; Dogs; Drug Resistance, Bacterial; Escherichia coli Infections / microbiology; Escherichia coli Infections / veterinary; Genotype; Microbial Sensitivity Tests; Urinary Tract Infections / microbiology; Urinary Tract Infections / veterinary; Uropathogenic Escherichia coli / classification; Uropathogenic Escherichia coli / drug effects; Uropathogenic Escherichia coli / genetics; Virulence Factors / genetics
TL;DR:
UPECs isolated from clinical cases of canine UTIs show a broad negative association between antimicrobial resistance and biofilm formation, and this observation is supported both by phenotypic and genotypic endpoints.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: November 9, 2020
2020 journal article
A highly efficient hybrid peptide ameliorates intestinal inflammation and mucosal barrier damage by neutralizing lipopolysaccharides and antagonizing the lipopolysaccharide-receptor interaction
FASEB JOURNAL, 34(12), 16049–16072.
author keywords: in silico; NF-kappa B signaling; peptide drug; proinflammatory cytokine; tight junction; Toll-like receptor
MeSH headings : Animals; Anti-Inflammatory Agents / pharmacology; Antimicrobial Cationic Peptides / pharmacology; Cell Line; Inflammation / chemically induced; Inflammation / drug therapy; Inflammation / metabolism; Interleukin-6 / metabolism; Intestinal Mucosa / drug effects; Intestinal Mucosa / metabolism; Lipopolysaccharides / pharmacology; Male; Mice; Mice, Inbred C57BL; Mucous Membrane / drug effects; Mucous Membrane / metabolism; NF-kappa B / metabolism; Peptides / pharmacology; RAW 264.7 Cells; Signal Transduction / drug effects; Toll-Like Receptor 4 / metabolism; Tumor Necrosis Factor-alpha / metabolism
TL;DR:
A novel hybrid anti‐inflammatory peptide that combines the active center of Cecropin A and the core functional region of LL‐37 (L) was designed through in silico analysis to reduce cytotoxicity and improve the anti-inflammatory activity of the parental peptides, suggesting that the newly designed peptide, C‐L, could be developed into a novel anti‐ inflammatory agent for animals or humans.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 9, 2020
2020 journal article
Fourfold alkyl wrapping of a copper(II) porphyrin thwarts macrocycle pi-pi stacking in a compact supramolecular package
ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY, 76, 647-+.
author keywords: porphyrin; pi-pi stacking prevention; facial encumbrance; copper(II); crystal structure; supramolecular chemistry
TL;DR:
In this study, a copper(II) porphyrin bearing four meso substituents, namely, {10,20-bis[2,6-bis(octyloxy)phenyl]-5,15-dibromoporphinato}copper(II), was prepared by metalation of the corresponding free-base porphyrsin and was characterized by single-crystal X-ray diffraction.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 9, 2020
2020 article
What is your diagnosis? Transtracheal wash in a horse
Mochizuki, H., Eaton, E., Breuhaus, B., & Stowe, D. M. (2020, December). VETERINARY CLINICAL PATHOLOGY, Vol. 49, pp. 675–677.
MeSH headings : Animals; Horses; Trachea
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: November 9, 2020
2020 journal article
Isolation of Chemically Cyclized Peptide Binders Using Yeast Surface Display
ACS COMBINATORIAL SCIENCE, 22(10), 519–532.
author keywords: cyclic peptides; interleukin-17 (IL-17); library screening; yeast-display libraries; affinity ligands
MeSH headings : Biophysical Phenomena; Cell Membrane / chemistry; Cyclization; Flow Cytometry; Humans; Interleukin-17 / chemistry; Molecular Docking Simulation; Peptide Library; Peptides, Cyclic / isolation & purification; Protein Binding; Protein Conformation; Protein Engineering; Recombinant Proteins / chemistry; Saccharomyces cerevisiae / chemistry; Saccharomyces cerevisiae / ultrastructure; Structure-Activity Relationship; Surface Properties
TL;DR:
The results show that yeast surface display can be used to efficiently isolate and characterize cyclic peptides generated by chemical modification from combinatorial libraries.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 9, 2020
2020 journal article
Human Cerebral Organoids Reveal Early Spatiotemporal Dynamics and Pharmacological Responses of UBE3A
STEM CELL REPORTS, 15(4), 845–854.
MeSH headings : Angelman Syndrome / pathology; Cell Line; Cell Nucleus / drug effects; Cell Nucleus / metabolism; Cerebrum / metabolism; Genomic Imprinting / drug effects; Humans; Neurons / drug effects; Neurons / metabolism; Organoids / drug effects; Organoids / metabolism; Time Factors; Topoisomerase Inhibitors / pharmacology; Ubiquitin-Protein Ligases / metabolism
TL;DR:
Human cerebral organoids are established as an important model for studying UBE3A and motivates their broader use in understanding complex neurodevelopmental disorders.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
4. Quality Education
(OpenAlex)
Source: Web Of Science
Added: November 9, 2020
2020 journal article
Cerebrospinal fluid lactate concentrations in dogs with seizure disorders
Journal of Veterinary Internal Medicine.
author keywords: acute repetitive seizures; biomarker; cluster seizures; epilepsy; status epilepticus
MeSH headings : Animals; Dog Diseases; Dogs; Epilepsy / veterinary; Humans; Lactic Acid; Seizures / veterinary; Status Epilepticus / veterinary
TL;DR:
Cerebrospinal fluid lactate concentration is minimally affected by seizure activity in dogs and increased concentrations are more likely associated with the underlying disease process.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: ORCID
Added: November 3, 2020
2020 review
CRISPR/Cas9 in Cancer Immunotherapy: Animal Models and Human Clinical Trials
[Review of ]. GENES, 11(8).
author keywords: genome editing; cancer; animal models; experimental oncology
MeSH headings : Animals; CRISPR-Cas Systems; Clinical Trials as Topic; Disease; Disease Models, Animal; Drug Evaluation, Preclinical; Gene Editing; Genetic Therapy; Humans; Immunotherapy; Immunotherapy, Adoptive; Neoplasms / etiology; Neoplasms / therapy; Precision Medicine / methods
TL;DR:
The aim of the article is to present the knowledge concerning the use of CRISPR Cas9 technique in targeting treatment-resistant cancers, and to present an overview of the limitations of the gene-editing tool.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 2, 2020
2020 journal article
Proteomic assessment of serum biomarkers of longevity in older men
AGING CELL, 19(11).
author keywords: aging; biomarker; inflammation; longevity; men; proteomics
MeSH headings : Aged; Biomarkers / blood; Humans; Longevity; Male; Proteomics / methods
TL;DR:
It is suggested that complex pathways, prominently including inflammation, are linked to the likelihood of attaining longevity and may serve to identify novel biomarkers for longevity and to understand the biology underlying lifespan.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: November 2, 2020
2020 review
Synthesis and Biomedical Potential of Azapeptide Modulators of the Cluster of Differentiation 36 Receptor (CD36)
[Review of ]. BIOMEDICINES, 8(8).
author keywords: semicarbazide; CD36; age-related macular degeneration; atherosclerosis; macrophage-driven inflammation; peptide
TL;DR:
The translation of GHRP-6 to potent and selective linear and cyclic azapeptide modulators of CD36 is outlined in this review which highlights the relevance of turn geometry for activity and the biomedical potential of prototypes for the beneficial treatment of a wide range of cardiovascular, metabolic and immunological disorders.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: November 2, 2020
2020 journal article
Transcriptome analysis of the hypothalamus and pituitary of turkey hens with low and high egg production
BMC GENOMICS, 21(1).
author keywords: Turkey; HPT axis; HPG axis; Gonadotropin production; Egg production
MeSH headings : Animals; Avian Proteins / genetics; Avian Proteins / metabolism; Eggs / standards; Estradiol / metabolism; Female; Fertility; Gonadotropin-Releasing Hormone / metabolism; Hypothalamus / metabolism; Pituitary Gland / metabolism; Transcriptome; Turkeys / genetics; Turkeys / physiology
TL;DR:
High egg producing hens (HEPH) show increased hypothalamic and pituitary gene expression related to hypothalamo-pituitary-gonadal (HPG) axis stimulation as well as increased in vitro responsiveness to gonadotropin releasing hormone (GnRH) stimulation in the pituitsary when compared to low egg producinghens (LEPH).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: November 2, 2020
2020 journal article
Integration of Wet-Lab Measures, Milk Infrared Spectra, and Genomics to Improve Difficult-to-Measure Traits in Dairy Cattle Populations
FRONTIERS IN GENETICS, 11.
Contributors: A. Cecchinato *, H. Toledo-Alvarado *, S. Pegolo *, A. Rossoni, E. Santus, C. Maltecca n , G. Bittante *, F. Tiezzi n
author keywords: high-throughput phenotyping; Fourier-transformed infrared spectroscopy; genetic parameters; genomic predictions; dairy cattle; single-step GBLUP
TL;DR:
Overall, these results demonstrated the potential of using FIELD information as indicator traits for the indirect genetic improvement of LAB measures, and suggests that breeding programs for difficult-to-measure traits could be implemented using FTIR information.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 2, 2020
2020 journal article
Age and Genetic Background Modify Hybrid Male Sterility in House Mice
GENETICS, 216(2), 585–597.
author keywords: hybrid male sterility; aging; genetic background; spermatogenesis; mouse
MeSH headings : Aging / genetics; Aging / physiology; Animals; Female; Genetic Background; Genetic Loci; Hybridization, Genetic; Infertility, Male / genetics; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Multifactorial Inheritance
TL;DR:
Results point to multiple segregating HMS modifier alleles, some of which have age-related modes of action, which will advance understanding both of the genetic architecture of HMS and of how reproductive barriers are maintained between house mouse subspecies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: November 2, 2020
2020 journal article
Evolutionary dynamics of Tomato spotted wilt virus within and between alternate plant hosts and thrips
SCIENTIFIC REPORTS, 10(1).
MeSH headings : Animals; Biodiversity; Biological Evolution; Datura stramonium / virology; Flowers / virology; Host Specificity / genetics; Insect Vectors / virology; Plant Diseases / genetics; Plant Diseases / virology; Thysanoptera / virology; Tospovirus / genetics; Tospovirus / isolation & purification
TL;DR:
It is suggested that high levels of genetic diversity together with the positive pleiotropic effects of mutations have allowed TSWV to rapidly adapt to new hosts and expand its host range.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: November 2, 2020
2020 journal article
Transmission of antimicrobial resistant non-O157 Escherichia coli at the interface of animal-fresh produce in sustainable farming environments
International Journal of Food Microbiology, 319, 108472.
author keywords: Pathogen transmission; Sustainable production systems; Antimicrobial resistance; Phylotyping; Non-O157 E. coli
MeSH headings : Ampicillin / pharmacology; Animals; Anti-Bacterial Agents / pharmacology; Enterotoxigenic Escherichia coli / drug effects; Enterotoxigenic Escherichia coli / genetics; Enterotoxigenic Escherichia coli / isolation & purification; Escherichia coli Infections / microbiology; Escherichia coli Infections / transmission; Farms; Foodborne Diseases / microbiology; Genome, Bacterial / genetics; Manure / microbiology; Microbial Sensitivity Tests; Serogroup; Streptomycin / pharmacology; Sulfisoxazole / pharmacology; Vegetables / microbiology
TL;DR:
The results of this study show the potential of AMR E. coli transmission between animal feeding operations and fresh produce, and more studies are recommended to study this interaction and prevent dissemination in sustainable farming systems.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: November 1, 2020
2020 journal article
Class 1 integron-borne cassettes harboring blaCARB-2 gene in multidrug-resistant and virulent Salmonella Typhimurium ST19 strains recovered from clinical human stool samples, United States
PLOS ONE, 15(10), e0240978.
Ed(s): I. Karunasagar
MeSH headings : Anti-Bacterial Agents / pharmacology; Drug Resistance, Multiple, Bacterial; Genome, Bacterial; Humans; Integrons; Microbial Sensitivity Tests; Phylogeny; Plasmids / genetics; Salmonella Infections / microbiology; Salmonella typhimurium / classification; Salmonella typhimurium / genetics; Salmonella typhimurium / isolation & purification; Salmonella typhimurium / pathogenicity; United States; Virulence Factors / genetics; Whole Genome Sequencing; beta-Lactamases / genetics
TL;DR:
Overall, S. Typhimurium strains displayed multidrug-resistant profile, being resistance to critically and highly important antimicrobials including ampicillin, ticarcillin/clavulanic acid, streptomycin and sulfisoxazole, chloramphenicol, tetracycline, respectively.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: November 1, 2020
2020 journal article
Environmental stressors affect intestinal permeability and repair responses in a pig intestinal ischemia model
TISSUE BARRIERS, 8(4).
author keywords: Intestinal barrier; ischemia; stress; pig model; tight junctions
MeSH headings : Animals; Disease Models, Animal; Humans; Intestines / physiopathology; Ischemia / physiopathology; Permeability; Swine
TL;DR:
The effects of a period of environmental acclimation versus acute transport stress on mucosal barrier repair after intestinal ischemic injury and recovery are reported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 27, 2020
2020 journal article
New Gene Markers Involved in Molecular Processes of Tissue Repair, Response to Wounding and Regeneration Are Differently Expressed in Fibroblasts from Porcine Oral Mucosa during Long-Term Primary Culture
Animals.
author keywords: primary culture; porcine; fibroblasts; microarray
TL;DR:
Following the analysis of gene expression in three previously identified groups of genes, it is identified that transforming growth factor beta 1, ITGB3, PDPN, and ETS1 are involved in all three processes, suggesting that these genes could be recognized as markers of repair specific for oral fibroblasts within the porcine mucosal tissue.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: October 27, 2020
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