Works Published in 2020
Displaying works 301 - 320 of 779 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2020 journal article
Derivation of stable embryonic stem cell-like, but transcriptionally heterogenous, induced pluripotent stem cells from non-permissive mouse strains
MAMMALIAN GENOME, 31(9-12), 263–286.
MeSH headings : Animals; Biomarkers; Cell Differentiation; Cells, Cultured; Cellular Reprogramming / genetics; Embryonic Stem Cells / cytology; Embryonic Stem Cells / metabolism; Gene Expression Profiling; Gene Expression Regulation, Developmental; Genetic Heterogeneity; Immunophenotyping; Induced Pluripotent Stem Cells / cytology; Induced Pluripotent Stem Cells / metabolism; Mice; Platelet Endothelial Cell Adhesion Molecule-1; Species Specificity; Transcriptome
TL;DR:
Heterogeneity is a naturally occurring, necessary quality of stem cells that allows for the maintenance of pluripotency and this study is the first study to derive stable ESC-like stem cells from the non-permissive NOD/ShiLtJ and WSB/EiJ strains, enabling easier and broader research possibilities into pluripOTency for these and similar non-Permissive mouse strains and species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: October 19, 2020
2020 chapter
Surgical disorders of the large intestine
In B. P. Smith, D. C. Van Metre, & N. Pusterla (Eds.), Large Animal Internal Medicine (6th edition). St. Louis, MO: Elsevier.
Ed(s): B. Smith, D. Van Metre & N. Pusterla
Source: NC State University Libraries
Added: October 18, 2020
2020 chapter
Surgical disorders of the small intestine
In B. P. Smith, D. C. Van Metre, & N. Pusterla (Eds.), Large Animal Internal Medicine (6th edition). St. Louis: Elsevier.
Ed(s): B. Smith, D. Van Metre & N. Pusterla
Source: NC State University Libraries
Added: October 18, 2020
2020 article
Estrogen receptor alpha, G-protein coupled estrogen receptor 1, and aromatase: Developmental, sex, and region-specific differences across the rat caudate-putamen, nucleus accumbens core and shell
JOURNAL OF COMPARATIVE NEUROLOGY.
author keywords: aromatase; estrogen receptor; rat; RRID AB_1141090; RRID AB_310305; RRID AB_566942; sex differences; striatum
MeSH headings : Animals; Caudate Nucleus / chemistry; Caudate Nucleus / growth & development; Caudate Nucleus / metabolism; Estrogen Receptor alpha / analysis; Estrogen Receptor alpha / biosynthesis; Female; Male; Nucleus Accumbens / chemistry; Nucleus Accumbens / growth & development; Nucleus Accumbens / metabolism; Putamen / chemistry; Putamen / growth & development; Putamen / metabolism; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled / analysis; Receptors, G-Protein-Coupled / biosynthesis; Sex Characteristics
TL;DR:
The hypothesis that ERα, GPER1, and aromatase exhibits sex, region, and age‐specific differences, including nuclear expression is tested, indicating that developmental period exerts critical sex‐specific influences on striatal cellular estrogenic mechanisms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality
(Web of Science)
Source: NC State University Libraries
Added: October 14, 2020
2020 article
Whole-genome sequencing identifies missense mutation inGRM6as the likely cause of congenital stationary night blindness in a Tennessee Walking Horse
EQUINE VETERINARY JOURNAL.
author keywords: horse; congenital stationary night blindness (CSNB); genetics; genomics; Tennessee Walking Horse; GRM6
MeSH headings : Animals; Eye Diseases, Hereditary / genetics; Eye Diseases, Hereditary / veterinary; Genetic Diseases, X-Linked; Horse Diseases / genetics; Horses; Mutation, Missense; Myopia; Night Blindness / genetics; Night Blindness / veterinary; Receptors, Glutamate / genetics; Tennessee
TL;DR:
A likely causal recessive missense variant in metabotropic glutamate receptor 6 (GRM6) is identified, which alters GRM6 binding, and thus signaling from the retinal rod cell to the ON-bipolar cell, impairing vision in low light conditions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: NC State University Libraries
Added: October 14, 2020
2020 journal article
Hopping species and borders: detection of Bartonella spp. in avian nest fleas and arctic foxes from Nunavut, Canada
PARASITES & VECTORS, 13(1).
author keywords: Arctic fox; Bartonella; Disease ecology; Flea; Geese; Nunavut; Vector-borne disease; Wildlife; Zoonotic
MeSH headings : Animals; Animals, Wild / microbiology; Bartonella / classification; Bartonella / genetics; Bartonella / isolation & purification; Bartonella / physiology; Bartonella Infections / microbiology; Bartonella Infections / transmission; Bartonella Infections / veterinary; Bird Diseases / microbiology; Disease Vectors; Ecosystem; Flea Infestations / parasitology; Flea Infestations / veterinary; Foxes / blood; Foxes / microbiology; Geese / microbiology; Host Specificity; Nunavut; Siphonaptera / classification; Siphonaptera / microbiology; Siphonaptera / physiology
TL;DR:
It is confirmed that B. henselae, B. vinsonii berkhoffii and B. rochalimae circulate in the Karrak Lake ecosystem and that nest fleas contain B. Henselae DNA, suggesting that this flea may serve as a potential vector for transmission among Arctic wildlife.
(via Semantic Scholar)
parasitesandvectors.biomedcentral.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 12, 2020
2020 article
Connecting the microbiome to host metabolites: understanding how the microbiome controls immune activity in birds
Koci, M., Ballou, A., Wei, X., Zhang, L., Liew, Z., & Ali, R. (2020, April). FASEB JOURNAL, Vol. 34.
TL;DR:
Analysis of the metabolites in serum and digesta from probiotic‐fed animals identified several metabolite changes correlate with the change in ATP levels in lymphocytes and putative changes in pro‐ and anti‐inflammatory cytokine production.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(OpenAlex)
Source: Web Of Science
Added: October 12, 2020
2020 review
Clinical Trial Design-A Review-With Emphasis on Acute Intervertebral Disc Herniation
[Review of ]. FRONTIERS IN VETERINARY SCIENCE, 7.
author keywords: explanatory; pragmatic; durotomy; glyburide; spinal cord injury
TL;DR:
In this review another key trial design decision—that between pragmatic and explanatory approaches—is highlighted and used as a theme to illustrate the close relationship between trial objective and design.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 12, 2020
2020 journal article
Effects of Autoclaving, EtOH, and UV Sterilization on the Chemical, Mechanical, Printability, and Biocompatibility Characteristics of Alginate
ACS BIOMATERIALS SCIENCE & ENGINEERING, 6(9), 5191–5201.
author keywords: hydrogels; tissue engineering and regenerative medicine; biofabrication; printability; human adipose-derived stem cells (hASC); nuclear magnetic resonance spectroscopy
MeSH headings : Alginates; Anti-Bacterial Agents; Ethanol; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Sterilization
TL;DR:
The autoclaving process, while demonstrating broad spectrum sterility effectiveness, also resulted in most notable changes in alginate's key properties, which significantly reduced the molecular weight and polydispersity index, as determined via gel permeation chromatography, as well as the dynamic viscosity ofAlginate.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: October 12, 2020
2020 journal article
Chronic subclinical mastitis reduces milk and components yield at the cow level
JOURNAL OF DAIRY RESEARCH, 87(3), 298–305.
author keywords: Chronic; pathogen; subclinical mastitis
MeSH headings : Animals; Bacterial Infections / microbiology; Bacterial Infections / pathology; Bacterial Infections / veterinary; Cattle; Chronic Disease; Female; Lactation; Mastitis, Bovine / diagnosis; Mastitis, Bovine / microbiology; Mastitis, Bovine / pathology; Milk
TL;DR:
Evaluating the effects of chronic subclinical mastitis caused by different types of pathogens on milk yield and milk components at the cow level and by pathogen using a linear mixed effects model found healthy cows produced more milk than each of the other groups and produced higher milk component yields than the chronicPC cows.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: October 12, 2020
2020 journal article
Plasma, urine and tissue concentrations of Flunixin and Meloxicam in Pigs
BMC VETERINARY RESEARCH, 16(1).
author keywords: Pig; Flunixin; Meloxicam; Pharmacokinetics; NSAIDs; Residue; Urine; Show
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Clonixin / analogs & derivatives; Clonixin / blood; Clonixin / pharmacokinetics; Clonixin / urine; Half-Life; Injections, Intramuscular / veterinary; Kidney / chemistry; Liver / chemistry; Male; Meloxicam / blood; Meloxicam / pharmacokinetics; Meloxicam / urine; Sus scrofa
TL;DR:
The data suggest that pigs given a single intramuscular dose of meloxicam or flunixin are likely to have detectable levels of the parent drug in urine up to 2 days and 5 days, respectively, after the first dose, but unlikely to have tissue residues above the US FDA tolerance or EU MRL following negative urine testing.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: October 12, 2020
2020 journal article
Association between lone star tick bites and increased alpha-gal sensitization: evidence from a prospective cohort of outdoor workers
PARASITES & VECTORS, 13(1).
author keywords: Alpha-gal; Amblyomma americanum; Red meat allergy
MeSH headings : Adult; Amblyomma / immunology; Amblyomma / physiology; Animals; Cattle; Disaccharides / immunology; Farmers; Female; Food Hypersensitivity / blood; Food Hypersensitivity / etiology; Food Hypersensitivity / immunology; Humans; Immunoglobulin E / blood; Immunoglobulin E / immunology; Male; Middle Aged; North Carolina; Prospective Studies; Red Meat / adverse effects; Tick Bites / complications; Tick Bites / immunology; Tick Bites / parasitology
TL;DR:
The results support the role of A. americanum bites and increased sensitization to alpha-gal as likely agents for eliciting an allergic response to red meat, and highlight the importance of preventing tick bites.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: October 12, 2020
2020 journal article
Development of Biomimetic Antimicrobial Platelet-Like Particles Comprised of Microgel Nanogold Composites
REGENERATIVE ENGINEERING AND TRANSLATIONAL MEDICINE, 6(3), 299–309.
author keywords: Synthetic platelet; Fibrin; Hemostatic material; Trauma; Antimicrobial material; Microgels
TL;DR:
These results demonstrate NGCs fabricated through noncovalent and covalent methods retain deformability necessary for clot collapse and exhibit some antimicrobial potential, and are promising materials for preventing blood loss and infection following traumatic injury.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: October 12, 2020
2020 article
iDISCO Allows Complete Visualization and Analysis of Postnatal Enteric Nervous System Development in a Comparative Pig Model
Erwin, S., Touvron, M., Odle, J., Van Landeghem, L., Blikslager, A., & Ziegler, A. (2020, April). FASEB JOURNAL, Vol. 34.
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 12, 2020
2020 journal article
Antimicrobial resistance and virulence factors profile of Salmonella spp. and Escherichia coli isolated from different environments exposed to anthropogenic activity
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE, 22, 578–583.
author keywords: Anthropogenic areas; Whole-genome sequencing; FosA7 gene; pHN7A8 (F33:A-:B-plasmid)
TL;DR:
The presence of these determinants in different anthropogenic areas suggests the need to conduct longitudinal studies for comparing the profile of pathogens across different environments and the detection of AMR determinants and virulence factors in these bacteria is significant in understanding the occurrence and even the development ofAMR.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(OpenAlex)
Sources: Web Of Science, ORCID
Added: October 12, 2020
2020 article
A Glial Cell Inhibitor Blocks Epithelial Barrier Repair in a Pig Model of Intestinal Ischemia
Sheridan, A., Pridgen, T., Odle, J., Van Landeghem, L., Blikslager, A., & Ziegler, A. (2020, April). FASEB JOURNAL, Vol. 34.
TL;DR:
It is hypothesized that EGC inhibition in juveniles will block epithelial barrier repair after ischemic injury mimicking the neonatal phenotype, and the development of glial‐epithelial crosstalk in barrier repair will ultimately guide novel clinical solutions to improve outcomes in neonatal patients affected by intestinal injury.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 12, 2020
2020 journal article
Lipidomic profiling of single mammalian cells by infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI)
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 412(29), 8211–8222.
author keywords: Single-cell analysis; Lipidome; Mass spectrometry; IR-MALDESI; Orbitrap
MeSH headings : Animals; HeLa Cells; Humans; Limit of Detection; Lipidomics; Rats; Reproducibility of Results; Single-Cell Analysis / methods; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
TL;DR:
A rapid and sensitive method for investigating the lipid profiles of isolated single cells using infrared matrix-assisted laser desorption electrospray ionization mass spectrometry (IR-MALDESI-MS), which provides an important basis for future work on differentiation between normal and diseased cells at various developmental states.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: October 12, 2020
2020 article
Effects of Oligosaccharide Supplementation on Intestinal Morphology and Enteric Glial Cell Marker Expression in a Neonatal Pig Model
Shapiro, L., Ziegler, A., Odle, J., Van Landeghem, L., & Blikslager, A. (2020, April). FASEB JOURNAL, Vol. 34.
TL;DR:
Test the effects of dietary oligosaccharides on postnatal changes in the EGC network and intestinal morphology in a neonatal pig model to find increased mucosal expression of EGC markers earlier in postnatal development in the high oligOSaccharide group, as well as histological changes consistent with enhanced rates of gut maturation in pigs fed a high oligosACcharide diet.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 12, 2020
2020 journal article
On empirical estimation of mode based on weakly dependent samples
COMPUTATIONAL STATISTICS & DATA ANALYSIS, 152.
author keywords: Bernstein polynomials; Empirical mode estimator; Strong consistency; Anderson-Darling test
TL;DR:
A non-parametric estimate of thedensity is proposed based on a sequence of mixtures of Beta densities which allows for the estimation of the mode even when the mode is possibly located on the boundary of the support of the density.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 12, 2020
2020 journal article
Decentralized cloud manufacturing-as-a-service (CMaaS) platform architecture with configurable digital assets
JOURNAL OF MANUFACTURING SYSTEMS, 56, 157–174.
author keywords: Cybermanufacturing; Blockchain; Smart contracts; Distributed digital thread; Cloud manufacturing
TL;DR:
The design, implementation and validation of middleware software architectures which aim to directly connect client users with manufacturing service providers while improving transparency, data integrity, data provenance and retaining data ownership to its creators are reported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
9. Industry, Innovation and Infrastructure
(Web of Science; OpenAlex)
12. Responsible Consumption and Production
(Web of Science)
Sources: Web Of Science, ORCID
Added: October 12, 2020
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