Works Published in 2012
Displaying works 661 - 680 of 691 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2012 journal article
Combined effect of cyclin D3 expression and abrogation of cyclin D1 prevent mouse skin tumor development
CELL CYCLE, 11(2), 335–342.
author keywords: cell cycle; D-type cyclins; skin; carcinogenesis; epidermis
MeSH headings : 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell / chemically induced; Carcinoma, Squamous Cell / metabolism; Carcinoma, Squamous Cell / pathology; Cell Proliferation; Cell Transformation, Neoplastic; Cyclin D1 / genetics; Cyclin D1 / metabolism; Cyclin D2 / metabolism; Cyclin D3 / genetics; Cyclin D3 / metabolism; Gene Expression Regulation; Mice; Mice, Transgenic; Oncogene Protein p21(ras) / genetics; Papilloma / chemically induced; Papilloma / metabolism; Papilloma / pathology; Skin / pathology; Skin Neoplasms / chemically induced; Skin Neoplasms / metabolism; Skin Neoplasms / pathology; Tumor Burden
TL;DR:
Modulation of the levels of particular members of the D-type cyclin family could be useful to inhibit tumor development and, in particular, ras-mediated tumorigenesis.
(via Semantic Scholar)
europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
CLINICAL ANESTHESIA AND ANALGESIA IN INVERTEBRATES
JOURNAL OF EXOTIC PET MEDICINE, 21(1), 59–70.
author keywords: analgesia; anesthesia; arthropods; invertebrates, mollusks; nociception; pain management
TL;DR:
A general overview of anesthetics and analgesics used in selective invertebrates and the discovery of nociceptive pathways similar to those in vertebrates is presented.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
14. Life Below Water
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2012 journal article
A predictive model for Efavirenz dosing
Pharmacogenomics, 13(2), 137–138.
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
The subcellular proteome of undifferentiated human embryonic stem cells
PROTEOMICS, 12(3), 421–430.
author keywords: Cell biology; Extracellular proteins; Human embryonic stem cells; Subcellular fractionation; Subcellular proteomics
MeSH headings : Animals; Cell Differentiation; Cells, Cultured; Culture Media, Conditioned; Cytosol / metabolism; Embryonic Stem Cells / cytology; Embryonic Stem Cells / metabolism; Endoplasmic Reticulum / genetics; Endoplasmic Reticulum / metabolism; Gene Expression Regulation, Developmental; Golgi Apparatus / genetics; Golgi Apparatus / metabolism; Humans; Membrane Proteins / genetics; Membrane Proteins / metabolism; Mice; Nuclear Proteins / genetics; Nuclear Proteins / metabolism; Signal Transduction / genetics; Subcellular Fractions / metabolism
TL;DR:
The results show that systematic subcellular proteome analysis is a valuable tool for studying hESC biology and shows that proteomic analysis of the endoplasmic reticulum and Golgi compartments is a powerful alternative approach to identify secreted proteins since these are synthesized in the ER and transit through the Golgi.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2012 journal article
Successful treatment of a novel generalized variant of canine discoid lupus erythematosus with oral hydroxychloroquine
VETERINARY DERMATOLOGY, 23(1), 65–E16.
MeSH headings : Administration, Oral; Animals; Antirheumatic Agents / therapeutic use; Dog Diseases / drug therapy; Dog Diseases / pathology; Dogs; Female; Hydroxychloroquine / therapeutic use; Lupus Erythematosus, Discoid / drug therapy; Lupus Erythematosus, Discoid / pathology; Lupus Erythematosus, Discoid / veterinary; Treatment Outcome
TL;DR:
A generalized variant of canine DLE successfully treated with the antimalarial immunomodulator hydroxychloroquine (HCQ) mirrored the generalized discoid variant of chronic cutaneous lupus erythematosus of humans, and the apparent benefit of HCQ, its safety and low cost warrant future investigations of its use for treatment of canine cutaneouslupus variants.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2012 journal article
S-Layer Homology Domain Proteins Csac_0678 and Csac_2722 Are Implicated in Plant Polysaccharide Deconstruction by the Extremely Thermophilic Bacterium Caldicellulosiruptor saccharolyticus
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 78(3), 768–777.
MeSH headings : Enzyme Stability; Glycoside Hydrolases / chemistry; Glycoside Hydrolases / genetics; Glycoside Hydrolases / metabolism; Gram-Positive Bacteria / enzymology; Gram-Positive Bacteria / genetics; Gram-Positive Bacteria / metabolism; Hydrogen-Ion Concentration; Membrane Glycoproteins / chemistry; Membrane Glycoproteins / genetics; Membrane Glycoproteins / metabolism; Molecular Weight; Open Reading Frames; Plants / microbiology; Polysaccharides / metabolism; Protein Binding; Sequence Deletion; Temperature
TL;DR:
Roles for Csac-0678 and Csac_2722 in recruitment and hydrolysis of complex polysaccharides and the deconstruction of lignocellulosic biomass are indicated and related SLH domain proteins in other Caldicellulosiruptor genomes may also be important contributors to plant biomass utilization.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(Web of Science)
12. Responsible Consumption and Production
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2012 journal article
Pharmacokinetics of intravenous and intramuscular buprenorphine in the horse
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 35(1), 52–58.
MeSH headings : Analgesics, Opioid / administration & dosage; Analgesics, Opioid / blood; Analgesics, Opioid / pharmacokinetics; Animals; Area Under Curve; Buprenorphine / administration & dosage; Buprenorphine / blood; Buprenorphine / pharmacokinetics; Cross-Over Studies; Female; Half-Life; Horses / blood; Horses / metabolism; Injections, Intramuscular; Injections, Intravenous; Male
TL;DR:
Buprenorphine has a moderate T(1/2) in the horse and was detected at concentrations expected to be therapeutic in other species after i.v. and i.m. administration of 0.005 mg/kg.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Nonparametric regression models for right-censored data using Bernstein polynomials
Computational Statistics and Data Analysis, 56(3), 559–573.
Contributors: M. Osman n & S. Ghosh n
author keywords: Bernstein polynomials; Censored data; Nonparametric regression; Nonproportional hazards; Sieve
TL;DR:
A new nonparametric regression model for the conditional hazard rate using a suitable sieve of Bernstein polynomials is presented and empirical results indicate that the proposed model has reasonably robust performance compared to other semiparametric models.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, NC State University Libraries
Added: August 6, 2018
2012 journal article
Modelling semi-continuous data using mixture regression models with an application to cattle production yields
Journal of Agricultural Science, 150(1), 109–121.
Contributors: E. Belasco * & S. Ghosh n
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
9. Industry, Innovation and Infrastructure
(Web of Science)
Sources: ORCID, NC State University Libraries
Added: August 6, 2018
2012 journal article
Infiltration and activation of acidophilic granulocytes in skin lesions of gilthead seabream, Sparus aurata, naturally infected with lymphocystis disease virus
Developmental and Comparative Immunology, 36(1), 174–182.
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
Experimental infection by capillary tube feeding of Rhipicephalus sanguineus with Bartonella vinsonii subspecies berkhoffii
Comparative Immunology, Microbiology and Infectious Diseases, 35(1), 9–15.
author keywords: Bartonella vinsonii subspecies berkhoffii; Rhipicephalus sanguineus; Artificial infection; Transmission
MeSH headings : Animals; Arachnid Vectors / microbiology; Bacterial Typing Techniques; Bartonella / genetics; Bartonella / physiology; Bartonella Infections / microbiology; Bartonella Infections / transmission; Bartonella Infections / veterinary; DNA, Bacterial / genetics; Dog Diseases / microbiology; Dog Diseases / transmission; Dogs; Feces / microbiology; Female; Polymerase Chain Reaction; Rabbits; Rhipicephalus sanguineus / microbiology
TL;DR:
To determine whether adult R. sanguineus ticks can be infected with a B. v. berkhoffii genotype II isolate via capillary tube feeding and whether the infection can then be transmitted from adult females to their eggs via trans-ovarial transmission, tick fecal material was collected and screened as a possible source of infectious inoculum for canine infections.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2012 journal article
Dietary calcium supplementation enhances efficacy but also toxicity of EGFR inhibitor therapy for colon cancer
CANCER BIOLOGY & THERAPY, 13(3), 130–137.
author keywords: colon cancer; EGFR; calcium; mouse models; AG1478; therapy; toxicity
MeSH headings : Animals; Antineoplastic Agents / pharmacology; Antineoplastic Agents / therapeutic use; Antineoplastic Agents / toxicity; Azoxymethane; Calcium / pharmacology; Calcium / therapeutic use; Calcium / toxicity; Cell Line, Tumor; Cell Proliferation / drug effects; Cell Survival / drug effects; Colonic Neoplasms / chemically induced; Colonic Neoplasms / drug therapy; Colonic Neoplasms / pathology; Dietary Supplements; Drug Screening Assays, Antitumor; Drug Synergism; ErbB Receptors / antagonists & inhibitors; Female; Humans; MAP Kinase Signaling System / drug effects; Male; Mice; Mice, Inbred C57BL; Quinazolines / pharmacology; Quinazolines / therapeutic use; Quinazolines / toxicity; Random Allocation; Tumor Burden / drug effects; Tyrphostins / pharmacology; Tyrphostins / therapeutic use; Tyrphostins / toxicity
TL;DR:
Calcium supplementation combined with pharmacologic blockade of EGFR results in an additive effect on tumor growth inhibition in all models and the combined use of dietary calcium supplementation and EGFR inhibitors also resulted in elevated toxicity suggesting that careful consideration be given when combining dietary supplements with prescribed cancer therapies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Characterization of turkey inducible nitric oxide synthase and identification of its expression in the intestinal epithelium following astrovirus infection
Comparative Immunology, Microbiology and Infectious Diseases, 35(1), 63–69.
Contributors: R. Meyerhoff n, P. Nighot n, R. Ali n, A. Blikslager n & M. Koci n
author keywords: Astrovirus; Enterocyte; Turkey; Inducible nitric oxide; Innate immunity
MeSH headings : Amino Acid Sequence; Animals; Astroviridae Infections / enzymology; Astroviridae Infections / veterinary; Astroviridae Infections / virology; Avastrovirus / physiology; Avian Proteins / genetics; Avian Proteins / metabolism; Bird Diseases / enzymology; Bird Diseases / virology; Enterocytes / enzymology; Enterocytes / pathology; Enterocytes / virology; Gene Expression; HEK293 Cells; Humans; Intestinal Mucosa / enzymology; Intestinal Mucosa / pathology; Intestinal Mucosa / virology; Lentivirus / genetics; Molecular Sequence Data; Nitric Oxide / biosynthesis; Nitric Oxide Synthase Type II / genetics; Nitric Oxide Synthase Type II / metabolism; Phylogeny; Recombinant Proteins / genetics; Recombinant Proteins / metabolism; Sequence Alignment; Transfection; Turkeys
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018
2012 journal article
Biological responses in rats exposed to cigarette smoke and Middle East sand (dust)
INHALATION TOXICOLOGY, 24(2), 109–124.
author keywords: Particle toxicity; nanoparticles; rat; in vivo; in vitro; pulmonary toxicity; cytotoxicity; dust inhalation
MeSH headings : Administration, Inhalation; Air Pollutants / toxicity; Animals; Behavior, Animal / drug effects; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid / chemistry; Bronchoalveolar Lavage Fluid / cytology; Dust / analysis; Gene Expression / drug effects; Hand Strength; Iraq; Larynx / drug effects; Larynx / pathology; Lung / drug effects; Lung / pathology; Lung / physiology; Male; Metals / analysis; Metals / toxicity; Motor Activity / drug effects; Oligonucleotide Array Sequence Analysis; Rats; Rats, Sprague-Dawley; Respiratory Function Tests; Respiratory Mucosa / drug effects; Respiratory Mucosa / pathology; Silicon Dioxide / analysis; Silicon Dioxide / toxicity; Tobacco Smoke Pollution / adverse effects; Trachea / drug effects; Trachea / pathology
TL;DR:
The studies show that the respiratory toxicity of IS is qualitatively similar to or less than that seen following short-term silica exposure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Strong influence of regional species pools on continent-wide structuring of local communities
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 279(1727), 266–274.
Contributors: J. Lessard *, M. Borregaard *, J. Fordyce *, C. Rahbek *, M. Weiser n, R. Dunn n , N. Sanders *
author keywords: regional species pool; community assembly; phylogenetics; tropical niche conservatism; diversity gradients; Formicidae
MeSH headings : Animals; Ants / physiology; Biodiversity; Climate; North America; Phylogeny; Population Dynamics; Temperature
TL;DR:
It is found that the average phylogenetic relatedness of species in ant communities decreases from tropical to temperate regions, but the strength of this relationship depends on the level of ecological realism in the definition of source pools.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2012 journal article
Nonphotochemical Base-Catalyzed Hydroxylation of 2,6-Dichloroquinone by H2O2Occurs by a Radical Mechanism
The Journal of Physical Chemistry B, 116(5), 1666–1676.
Contributors: S. Franzen n , K. Sasan, B. Sturgeon*, B. Lyon*, B. Battenburg*, H. Gracz*, R. Dumariah, R. Ghiladi*
MeSH headings : Animals; Benzoquinones / chemistry; Benzoquinones / metabolism; Catalysis; Chlorophenols / metabolism; Hydrogen Peroxide / metabolism; Peroxidases / metabolism; Polychaeta / enzymology; Polychaeta / metabolism
TL;DR:
The control experiments and precedents in studies of other peroxidases lead to the conclusion that hydroxylation will be observed following any process that leads to the formation of the 2,6-DCQ at pH > 7, regardless of the catalyst used in the2,4, 6-TCP oxidation reaction.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2012 journal article
Mixed model analysis of censored longitudinal data with flexible random-effects density
BIOSTATISTICS, 13(1), 61–73.
author keywords: Censoring; HCV; HIV; Limit of quantification; Longitudinal data; Random effects
MeSH headings : Antiviral Agents / therapeutic use; Bias; Biostatistics; Data Interpretation, Statistical; Hepatitis C / drug therapy; Hepatitis C / virology; Humans; Interferon-alpha / therapeutic use; Linear Models; Longitudinal Studies; Models, Statistical; Statistics, Nonparametric; Viral Load / drug effects
TL;DR:
A mixed model framework for censored longitudinal data in which the random effects are represented by the flexible seminonparametric density is developed andSimulations show that this approach can lead to reduction in bias and increase in efficiency relative to assuming Gaussian random effects.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2012 journal article
Efficient sorption of polyphenols to soybean flour enables natural fortification of foods
Food Chemistry, 131(4), 1193–1200.
TL;DR:
It is demonstrated that defatted soybean flour (DSF) can sorb polyphenols from blueberry and cranberry juices while separating them from sugars, providing a means to create protein-rich food ingredients containing concentrated plant bioactives without excess sugars, fats and water that can be incorporated in a variety of scientifically validated functional foods and dietary supplements.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: NC State University Libraries, ORCID
Added: August 6, 2018
2012 journal article
Constrained polymer chain behavior observed in their non-stoichiometric cyclodextrin inclusion complexes
Journal of Inclusion Phenomena and Macrocyclic Chemistry, 72(1-2), 71–78.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
Chloride channel ClC-2 modulates tight junction barrier function via intracellular trafficking of occludin
American Journal of Physiology-Cell Physiology, 302(1), C178–C187.
Contributors: P. Nighot n & A. Blikslager n
author keywords: Caco-2; epithelium; intestine; permeability
MeSH headings : CLC-2 Chloride Channels; Caco-2 Cells; Caveolae / metabolism; Caveolae / physiology; Cell Communication / physiology; Chloride Channels / metabolism; Chloride Channels / physiology; Humans; Intracellular Fluid / metabolism; Intracellular Fluid / physiology; Membrane Proteins / metabolism; Membrane Proteins / physiology; Occludin; Protein Transport / physiology; Tight Junctions / metabolism; Tight Junctions / physiology
TL;DR:
Data indicate that ClC-2 plays an important role in the modulation of tight junctions by influencing caveolar trafficking of the tight junction protein occludin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018
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