Works Published in 2013
Displaying works 681 - 700 of 743 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2013 journal article
Environmental, institutional, and demographic predictors of environmental literacy among middle school children
PLoS One, 8(3).
Source: NC State University Libraries
Added: August 6, 2018
2013 journal article
Enhanced Striatal beta 1-Adrenergic Receptor Expression Following Hormone Loss in Adulthood Is Programmed by Both Early Sexual Differentiation and Puberty: A Study of Humans and Rats
ENDOCRINOLOGY, 154(5), 1820–1831.
MeSH headings : Adolescent; Adult; Aging / genetics; Aging / metabolism; Aging / physiology; Animals; Corpus Striatum / growth & development; Corpus Striatum / metabolism; Estradiol / deficiency; Estradiol / pharmacology; Female; Gene Expression Regulation, Developmental / physiology; Hormones / deficiency; Hormones / pharmacology; Humans; Male; Ovariectomy; Puberty / genetics; Puberty / metabolism; Puberty / physiology; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta-1 / genetics; Receptors, Adrenergic, beta-1 / metabolism; Sex Differentiation / drug effects; Sex Differentiation / genetics; Sex Differentiation / physiology; Time Factors; Up-Regulation / genetics; Up-Regulation / physiology
TL;DR:
It is demonstrated that critical periods early in life and at puberty program adult gene responsiveness to hormone loss after gonadectomy and potentially reproductive senescence, indicating the necessity of pubertal development and adult ovariectomy.
(via Semantic Scholar)
academic.oup.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2013 journal article
Early Life Stress Triggers Persistent Colonic Barrier Dysfunction and Exacerbates Colitis in Adult IL-10(-/-) Mice
INFLAMMATORY BOWEL DISEASES, 19(4), 712–719.
author keywords: psychological stress; neonatal maternal separation; inflammatory bowel disease; colitis; animal models of IBD; barrier function
MeSH headings : Animals; Animals, Newborn; Cell Membrane Permeability; Cells, Cultured; Colitis / etiology; Colitis / pathology; Colon / metabolism; Colon / pathology; Cytokines / metabolism; Female; Interleukin-10 / physiology; Mast Cells / metabolism; Mast Cells / pathology; Maternal Deprivation; Mice; Mice, Inbred C57BL; Mice, Knockout; Stress, Psychological / complications
TL;DR:
It is demonstrated that colitis in IL-10−/− mice can be exacerbated by NMS stress, and the precise mechanisms of enhanced colitis severity in NMS IL10− /− mice are unclear but persistent defects in intestinal barrier function likely play a contributing role.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
EVALUATION OF TWO OBJECTIVE METHODS TO OPTIMIZE KVP AND PERSONNEL EXPOSURE USING A DIGITAL INDIRECT FLAT PANEL DETECTOR AND SIMULATED VETERINARY PATIENTS
VETERINARY RADIOLOGY & ULTRASOUND, 54(1), 9–16.
author keywords: digital flat panel detector; FOM; figure of merit; kVp; SdNR; signal difference-to-noise ratio; small animal digital radiography; personnel exposure
MeSH headings : Animal Technicians; Animals; Humans; Occupational Exposure / prevention & control; Phantoms, Imaging / standards; Phantoms, Imaging / veterinary; Quality Control; Radiation Dosage; Radiation Monitoring / instrumentation; Radiation Monitoring / methods; Radiographic Image Enhancement / instrumentation; Radiographic Image Enhancement / methods; Reference Values; Signal-To-Noise Ratio
TL;DR:
Evaluated methods for determining optimal kVp values for an indirect flat panel digital detector indicated that a single standard technique was only optimal for most medium-sized patients, and images of thinner patients should be made with a lower kVP.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Differences in X-Chromosome Transcriptional Activity and Cholesterol Metabolism between Placentae from Swine Breeds from Asian and Western Origins
PLOS ONE, 8(1).
MeSH headings : Animals; Cholesterol / metabolism; Computational Biology; Female; Fertility / physiology; Gene Expression Profiling / veterinary; Gestational Age; Linear Models; Microarray Analysis / veterinary; Placenta / metabolism; Placenta / physiology; Pregnancy; RNA, Long Noncoding / genetics; Real-Time Polymerase Chain Reaction / veterinary; Reverse Transcriptase Polymerase Chain Reaction / veterinary; Species Specificity; Swine / genetics; Swine / physiology; Transcription, Genetic / physiology; X Chromosome / genetics; X Chromosome / metabolism
TL;DR:
This work identifies key metabolic pathways that differ in the placentae of two swine breeds noted for differences in reproductive prolificacy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Development of a New Positron Emission Tomography Tracer for Targeting Tumor Angiogenesis: Synthesis, Small Animal Imaging, and Radiation Dosimetry
MOLECULES, 18(5), 5594–5610.
author keywords: development of new 64Cu radiolabeled peptide; radiopharmaceuticals; targeted radioconjugates; positron emission tomography (PET) imaging; tumor angiogenesis; tumor aggressiveness; responses to therapy
MeSH headings : Animals; Carcinoma, Lewis Lung / diagnostic imaging; Carcinoma, Lewis Lung / metabolism; Copper / chemistry; Female; Isotopes / chemistry; Mice; Neovascularization, Pathologic / diagnostic imaging; Neovascularization, Pathologic / metabolism; Peptides / chemical synthesis; Peptides / chemistry; Peptides / pharmacology; Positron-Emission Tomography; Radiography; Radiopharmaceuticals / chemical synthesis; Radiopharmaceuticals / chemistry; Radiopharmaceuticals / pharmacology
TL;DR:
The results from this study show that, in the context of the s.c. LLC immunocompetent mouse model, the QFP-tracer can target tumor blood vessels selectively, however, further optimization of the biodistribution and dosimetry profile of the tracer is necessary to ensure efficient radiopharmaceutical applications enabled by the biological specificity of the Q FP-peptide.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Developing Predictive Approaches to Characterize Adaptive Responses of the Reproductive Endocrine Axis to Aromatase Inhibition: II. Computational Modeling
TOXICOLOGICAL SCIENCES, 133(2), 234–247.
author keywords: endocrine disruptors; biological modeling; non-mammalian species; dose response; biomarkers
MeSH headings : Adaptation, Physiological / drug effects; Animal Testing Alternatives; Animals; Aromatase Inhibitors / toxicity; Computer Simulation; Cyprinidae / physiology; Dose-Response Relationship, Drug; Estradiol / blood; Estrogen Antagonists / toxicity; Fadrozole / toxicity; Female; Hypothalamo-Hypophyseal System / drug effects; Hypothalamo-Hypophyseal System / enzymology; Male; Ovary / drug effects; Ovary / enzymology; Predictive Value of Tests; Time Factors
TL;DR:
A computational model of the hypothalamic-pituitary-gonadal (HPG) axis in female fathead minnows is developed to predict dose-response and time-course behaviors for endocrine effects of the aromatase inhibitor, fadrozole (FAD).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Demographics, diet, movements, and survival of an isolated, unmanaged raccoon Procyon lotor (Procyonidae, Carnivora) population on the Outer Banks of North Carolina
Mammalia, 77(1), 21–30.
TL;DR:
The population was skewed toward older animals and exhibited delayed breeding, typical of populations at high density with few sources of mortality, and poor body condition and low recruitment suggested a population near carrying capacity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Source: NC State University Libraries
Added: August 6, 2018
2013 journal article
Cowhage can induce itch in the atopic dog
EXPERIMENTAL DERMATOLOGY, 22(6), 435–437.
Contributors: T. Olivry n , P. Bizikova n, J. Paps n, S. Dunston n, E. Lerner* & G. Yosipovitch *
author keywords: canine; dog; itch; model; pruritus
MeSH headings : Animals; Dermatitis, Atopic / etiology; Dermatitis, Atopic / physiopathology; Dogs; Hot Temperature; Inflammation; Mucuna / metabolism; Peptide Hydrolases / chemistry; Protein Denaturation; Pruritus / etiology; Pruritus / physiopathology; Random Allocation; Recombinant Proteins / chemistry; Skin / drug effects; Skin Tests / methods
TL;DR:
Cowhage spicules, protein‐rich extracts and mucunain can all inducePruritus and inflammation in dogs as in other species, but the inconsistency of provocation is currently a limitation of this challenge type for future studies of pruritus in dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2013 journal article
Comparison of automated versus manual neutrophil counts for the detection of cellular abnormalities in dogs receiving chemotherapy: 50 cases (May to June 2008)
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 242(11), 1539–1543.
MeSH headings : Animals; Antineoplastic Agents / adverse effects; Antineoplastic Agents / therapeutic use; Dog Diseases / blood; Dog Diseases / drug therapy; Dogs; Neoplasms / drug therapy; Neoplasms / veterinary; Neutropenia / chemically induced; Neutropenia / diagnosis; Neutropenia / veterinary; Neutrophils / physiology; Retrospective Studies
TL;DR:
An automated CBC appears to be accurate for neutrophil counts, but a microscopic examination of the corresponding blood smear is still recommended; further studies are needed to determine whether the detection or frequency of these abnormalities would differ dependent on chemotherapy protocol, neoplastic disease, and decision thresholds used by the oncologist in the ordering of a CBC without a blood smear evaluation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2013 journal article
Bayesian Average Error-Based Approach to Sample Size Calculations for Hypothesis Testing
JOURNAL OF BIOPHARMACEUTICAL STATISTICS, 23(3), 569–588.
Contributors: E. Reyes* & S. Ghosh n
author keywords: Bayes factor; Bayesian average errors; Hypothesis testing; Sample size determination
MeSH headings : Algorithms; Anticholesteremic Agents / adverse effects; Anticholesteremic Agents / therapeutic use; Bayes Theorem; Child; Clinical Trials as Topic / statistics & numerical data; Data Interpretation, Statistical; Fluorobenzenes / adverse effects; Fluorobenzenes / therapeutic use; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors / adverse effects; Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use; Patient Safety; Pyrimidines / adverse effects; Pyrimidines / therapeutic use; Rosuvastatin Calcium; Sample Size; Sulfonamides / adverse effects; Sulfonamides / therapeutic use
TL;DR:
This work considers rejecting the null hypothesis, in favor of the alternative, when a test statistic exceeds a cutoff, and chooses the cutoff to minimize a weighted sum of Bayesian average errors and the sample size to bound the total error for the hypothesis test.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2013 journal article
Atmospheric plasma application to improve adhesion of electrospun nanofibers onto protective fabric
JOURNAL OF ADHESION SCIENCE AND TECHNOLOGY, 27(8), 924–938.
author keywords: adhesion; atmospheric pressure plasma; cross-linking; dielectric barrier discharge; electrospinning; water contact angle
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2013 journal article
Aqueous–membrane partitioning of β-substituted porphyrins encompassing diverse polarity
New Journal of Chemistry, 37(4), 1087.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2013 journal article
A topical aqueous calcineurin inhibitor for the treatment of naturally occurring keratoconjunctivitis sicca in dogs
VETERINARY OPHTHALMOLOGY, 16(3), 192–197.
author keywords: calcineurin inhibitor; canine; clinical trial; keratoconjunctivitis sicca
MeSH headings : Administration, Topical; Animals; Calcineurin Inhibitors; Cyclosporins / pharmacology; Dog Diseases / drug therapy; Dogs; Double-Blind Method; Keratoconjunctivitis Sicca / drug therapy; Keratoconjunctivitis Sicca / veterinary; Pilot Projects
TL;DR:
Results indicate that topical SCY-641, in a stable clear aqueous solution, is efficacious in a spontaneous model of KCS and warrants further evaluation as a treatment of immune-mediated KCS.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
A systematic review of randomized controlled trials for prevention or treatment of atopic dermatitis in dogs: 2008-2011 update
VETERINARY DERMATOLOGY, 24(1), 97-+.
Contributors: T. Olivry n & P. Bizikova n
MeSH headings : Animals; Anti-Inflammatory Agents / therapeutic use; Dermatitis, Atopic / therapy; Dermatitis, Atopic / veterinary; Dog Diseases / prevention & control; Dog Diseases / therapy; Dogs; Immunosuppressive Agents / therapeutic use; Randomized Controlled Trials as Topic
TL;DR:
Topical or oral glucocorticoids and oral ciclosporin remain the interventions with highest evidence for efficacy and relative safety for treatment of canine AD.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2013 journal article
A mega-analysis of genome-wide association studies for major depressive disorder
Molecular Psychiatry, 18(4), 497–511.
Source: NC State University Libraries
Added: August 6, 2018
2013 journal article
mRNA display selection and solid-phase synthesis of Fc-binding cyclic peptide affinity ligands
Biotechnology and Bioengineering, 110(3), 857–870.
author keywords: cyclic peptide; mRNA display; Fc binding; affinity ligand; library
MeSH headings : Humans; Immunoglobulin Fc Fragments / metabolism; Peptide Library; Peptides, Cyclic / chemistry; Peptides, Cyclic / genetics; Peptides, Cyclic / isolation & purification; Peptides, Cyclic / metabolism; Protein Binding; Protein Engineering / methods; RNA, Messenger / genetics; Solid-Phase Synthesis Techniques / methods
TL;DR:
The discovery, synthesis and characterization of novel cyclic peptide affinity ligands that bind the Fc portion of human Immunoglobulin G (IgG; hFc) are described and the approach can be extended to efficiently generate and evaluatecyclic peptides for other targets of interest.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2013 journal article
Use of population pharmacokinetic modeling and Monte Carlo simulation to capture individual animal variability in the prediction of flunixin withdrawal times in cattle
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 36(3), 248–257.
MeSH headings : Algorithms; Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Cattle / blood; Clonixin / administration & dosage; Clonixin / analogs & derivatives; Clonixin / pharmacokinetics; Computer Simulation; Drug Administration Routes; Drug Residues / pharmacokinetics; Female; Liver / metabolism; Male; Models, Biological; Monte Carlo Method
TL;DR:
This study questions the use of small groups of healthy animals to determine WDTs for drugs intended for administration to large diverse populations and may warrant a reevaluation of the current procedure for establishing WDT to prevent violative residues of flunixin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Synthesis and characterization of lipophilic, near-IR absorbing metallobacteriochlorins
Chemical Journal of Chinese Universities, 34(4), 776–781.
Source: NC State University Libraries
Added: August 6, 2018
2013 journal article
Skp2 Deficiency Inhibits Chemical Skin Tumorigenesis Independent of p27(Kip1) Accumulation
AMERICAN JOURNAL OF PATHOLOGY, 182(5), 1854–1864.
MeSH headings : Animals; Apoptosis; Carcinogenesis / metabolism; Carcinogenesis / pathology; Cell Cycle; Cyclin-Dependent Kinase Inhibitor p27 / metabolism; Epidermis / metabolism; Epidermis / pathology; Gene Deletion; Humans; Kinetics; Mice; Mice, Inbred C57BL; Papilloma / metabolism; Papilloma / pathology; S-Phase Kinase-Associated Proteins / metabolism; Skin Neoplasms / metabolism; Skin Neoplasms / pathology; Tumor Suppressor Protein p53 / deficiency; Tumor Suppressor Protein p53 / metabolism
TL;DR:
It is concluded that p27(Kip1) accumulation is responsible for the hypoplasia observed in normal tissues of Skp2(-/-) mice but does not have a preponderant function in reducing skin tumorigenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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