Works Published in 2011
Displaying works 61 - 80 of 685 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2011 journal article
Genetic Analysis of H1N1 Influenza Virus from Throat Swab Samples in a Microfluidic System for Point-of-Care Diagnostics
Journal of the American Chemical Society, 133(23), 9129–9135.
MeSH headings : DNA, Single-Stranded / genetics; DNA, Single-Stranded / isolation & purification; Electrochemistry / instrumentation; Influenza A Virus, H1N1 Subtype / genetics; Influenza A Virus, H1N1 Subtype / isolation & purification; Limit of Detection; Magnetics; Microfluidic Analytical Techniques; Pharynx / virology; Point-of-Care Systems; Protein Denaturation; RNA, Viral / genetics; RNA, Viral / isolation & purification; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleoproteins / chemistry; Specimen Handling
TL;DR:
The Magnetic Integrated Microfluidic Electrochemical Detector (MIMED) is presented that integrates sample preparation and electrochemical sensors in a monolithic disposable device to detect RNA-based virus directly from throat swab samples and demonstrates the detection of influenza H1N1 in throat swabs at loads as low as 10 TCID(50), 4 orders of magnitude below the clinical titer for this virus.
(via Semantic Scholar)
europepmc.org (repository)
Sources: Crossref, ORCID
Added: July 11, 2021
2011 journal article
Improving Aptamer Selection Efficiency through Volume Dilution, Magnetic Concentration, and Continuous Washing in Microfluidic Channels
Analytical Chemistry, 83(17), 6883–6889.
MeSH headings : Aptamers, Nucleotide / chemistry; Magnetics; Microfluidic Analytical Techniques / methods; SELEX Aptamer Technique; Streptavidin / analysis
TL;DR:
This method retrieves a small number of magnetic beads suspended in a large volume and concentrates them into a microfluidic chamber with minimal loss for continuous washing and obtained new DNA aptamer sequences with low nanomolar affinity that specifically bind to the SA proteins.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: July 11, 2021
2011 journal article
Probing the Limits of Aptamer Affinity with a Microfluidic SELEX Platform
PLoS ONE, 6(11), e27051.
Ed(s): M. Antopolsky
MeSH headings : Animals; Aptamers, Nucleotide / genetics; Aptamers, Nucleotide / metabolism; Base Sequence; Becaplermin; Microfluidic Analytical Techniques / methods; Protein Binding; Proto-Oncogene Proteins c-sis / metabolism; SELEX Aptamer Technique / instrumentation
TL;DR:
This work has developed a microfluidic selection process (M-SELEX) that can be used to obtain high affinity aptamers against diverse protein targets and discovers novel aptamer sequences that bind to platelet derived growth factor B and thrombin and a new aptamer that binds to apolipoprotein E3.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: July 11, 2021
2011 journal article
Polarity-Switching Electrochemical Sensor for Specific Detection of Single-Nucleotide Mismatches
Angewandte Chemie International Edition, 50(47), 11176–11180.
author keywords: DNA; electrochemistry; sensors; single-nucleotide mismatch
MeSH headings : Base Pair Mismatch; Biosensing Techniques / instrumentation; Biosensing Techniques / methods; DNA / analysis; DNA / genetics; DNA Probes; Electrochemistry / instrumentation; Electrochemistry / methods; Electrodes; Polymorphism, Single Nucleotide
TL;DR:
A single-step, room-temperature electrochemical sensor that detects single-nucleotide mismatches with a “polarity-switching” response and describes the design principles of the bipolar sensor and demonstrates its performance in discriminating SM and PM targets under various conditions.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: July 11, 2021
2011 journal article
Measurement of Aptamer–Protein Interactions with Back-Scattering Interferometry
Analytical Chemistry, 83(23), 8867–8870.
MeSH headings : Aptamers, Nucleotide / chemistry; Aptamers, Nucleotide / metabolism; Humans; Interferometry; Light; Protein Binding; Solutions / chemistry; Thrombin / chemistry; Thrombin / metabolism
TL;DR:
The quantitative measurement of aptamer-protein interactions using backscattering interferometry (BSI) is reported and it is shown that BSI can determine when distinct binding regions are accessed and preliminary modeling efforts suggest evidence for allosteric linkage between the two exosites.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: July 11, 2021
2011 journal article
Two-Step, PCR-Free Telomerase Detection by Using Exonuclease III-Aided Target Recycling
ChemBioChem, 12(18), 2745–2747.
author keywords: cancer; nucleic acid detection; signal amplification; telomerase
MeSH headings : Base Sequence; Cell Line; Chromatography, High Pressure Liquid; DNA Probes; Exodeoxyribonucleases / metabolism; Humans; Mass Spectrometry; Polymerase Chain Reaction / methods; Telomerase / metabolism
TL;DR:
The sensitive detection of telomerase activity is reported by using exonuclease III-aided target recycling to amplify the signal produced by a chimeric LNA-DNA molecular beacon in a single-measurement fluorescence assay.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID
Added: July 11, 2021
2011 journal article
Re-engineering multicloning sites for function and convenience
Nucleic Acids Research, 39(14), e92–e92.
MeSH headings : 5' Untranslated Regions; Cloning, Molecular / methods; Codon; Genetic Vectors / chemistry; Promoter Regions, Genetic; Protein Biosynthesis; Saccharomyces cerevisiae / genetics
TL;DR:
This work develops and applies a novel predictive model of structure-based translation inhibition to design improved MCSs for significantly higher and more consistent protein expression, and was able to minimize the inhibitory effects of M CSs with the yeast TEF, CYC and GPD promoters.
(via Semantic Scholar)
Source: ORCID
Added: May 6, 2021
2011 article
Using Flux Balance Analysis to Guide Microbial Metabolic Engineering
Curran, K. A., Crook, N. C., & Alper, H. S. (2011, November). Microbial Metabolic Engineering, pp. 197–216.
author keywords: Flux balance analysis; MOMA; Genomic-scale metabolic model; Metabolic engineering; Strain engineering
MeSH headings : Algorithms; Computational Biology / methods; Internet; Metabolic Engineering / methods; Metabolic Networks and Pathways / genetics; Models, Biological; Reproducibility of Results; Software
TL;DR:
Fux balance analysis (FBA) is a mathematical approach that uses a genomic-scale metabolic network models to afford in silico prediction and optimization of metabolic changes.
(via Semantic Scholar)
Source: ORCID
Added: May 6, 2021
2011 conference paper
Shape Restricted Nonparametric Regression For Econometric Models
Presented at the 2nd International IIMA Conference, Ahmedabad, India.
Event: 2nd International IIMA Conference at Ahmedabad, India on January 8-10, 2011
Source: NC State University Libraries
Added: May 4, 2021
2011 speech
High-dimensional Multivariate Imputation Methods for ARMS Data
Ghosh, S. (2011, March). Presented at the Department of Statistics, Iowa State University, Ames, IA.
Event: Department of Statistics, Iowa State University at Ames, IA on March 21, 2011
Source: NC State University Libraries
Added: May 4, 2021
2011 speech
Regional Analysis on the Effects of Environmental Stressors on Health Related Incidents
Ghosh, S. (2011, June). Presented at the Centers for Disease Control and Prevention, Hyattsville, MD.
Event: Centers for Disease Control and Prevention at Hyattsville, MD on June 6, 2011
Source: NC State University Libraries
Added: May 4, 2021
2011 conference paper
Meta Analysis and Multiple Testing
Ghosh, S. (2011, June 17). Presented at the NISS Workshop on Difficulties with Observational Medical Studies, Research Triangle Park, NC.
Event: NISS Workshop on Difficulties with Observational Medical Studies at Research Triangle Park, NC on June 17, 2011
Source: NC State University Libraries
Added: May 4, 2021
2011 conference paper
Some of Your Data are Imputed. What Should You Do?
Presented at the Joint Annual Meeting of the Agricultural & Applied Economics Association, Pittsburgh, PA.
Event: Joint Annual Meeting of the Agricultural & Applied Economics Association at Pittsburgh, PA on July 23-26, 2011
Source: NC State University Libraries
Added: May 4, 2021
2011 conference paper
Bayesian Meta Analysis for Comparative Effectiveness Research
Ghosh, S. (2011, August 21). Presented at the 32nd Annual Conference of the International Society for Clinical Biostatistics, Ottawa, Canada.
Event: 32nd Annual Conference of the International Society for Clinical Biostatistics at Ottawa, Canada on August 21-25, 2011
Source: NC State University Libraries
Added: May 4, 2021
2011 speech
Bayesian Methods: Theory & Applications
Bayesian Methods: Theory & Applications. Presented at the Short Course at United Network of Organ Sharing, Richmond, VA.
Event: Short Course at United Network of Organ Sharing at Richmond, VA on October 13-14, 2011
Source: NC State University Libraries
Added: May 4, 2021
2011 speech
Bayesian Methods for Non-inferiority Tests and Sample Size Determination
Ghosh, S. (2011, November). Presented at the Biopharmaceutical Section of ASA Web-based Training Series.
Event: Biopharmaceutical Section of ASA Web-based Training Series on November 18, 2011
Source: NC State University Libraries
Added: May 4, 2021
2011 conference paper
Smooth Density Estimation Under Moment Constraint
Presented at the International Conference in Mathematics and Applications, Bangkok, Thailand.
Event: International Conference in Mathematics and Applications at Bangkok, Thailand on December 17-19, 2011
Source: NC State University Libraries
Added: May 4, 2021
2011 journal article
The CADUCEUS (CArdiosphere-Derived aUtologous Stem CElls to Reverse ventricUlar dySfunction) Trial
Circulation, 124, 2365–2374.
Source: NC State University Libraries
Added: April 24, 2021
2011 chapter
Bivalves
In Invertebrate Medicine (pp. 127–151).
Sources: Crossref, ORCID
Added: April 23, 2021
2011 journal article
Integration of Environmental Stewardship and Local Economic Development to Enhance Community Health
North Carolina Medical Journal, 72(2), 141–144.
Sources: Crossref, ORCID
Added: April 23, 2021
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