Works Published in 1996
Displaying works 121 - 140 of 172 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
1996 journal article
Interleukin-1 beta increases prostaglandin E(2)-stimulated adenosine 3',5'-cyclic monophosphate production in rabbit pigmented ciliary epithelium
EXPERIMENTAL EYE RESEARCH, 63(1), 91–104.
author keywords: ciliary epithelium; cyclic AMP, interleukin-1; prostaglandins; transforming growth factor-beta; pigmented ciliary epithelium
MeSH headings : Animals; Cells, Cultured; Colforsin / pharmacology; Cyclic AMP / biosynthesis; Cycloheximide / pharmacology; Cyclooxygenase Inhibitors / pharmacology; Dinoprostone / pharmacology; Dose-Response Relationship, Drug; Indomethacin / pharmacology; Interleukin-1 / pharmacology; Isoproterenol / pharmacology; Kinetics; Lipopolysaccharides / pharmacology; Pigment Epithelium of Eye / drug effects; Pigment Epithelium of Eye / metabolism; Protein Synthesis Inhibitors / pharmacology; Rabbits; Stimulation, Chemical; Transforming Growth Factor beta / pharmacology; Tumor Necrosis Factor-alpha / pharmacology; Up-Regulation; Vasoactive Intestinal Peptide / pharmacology
TL;DR:
This is the first report of prostaglandin E2-induced stimulation of adenosine 3',5'-cyclic monophosphate production by pigmented ciliary epithelial cells and of the unique ability of interleukin-1 to increase this effect.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1996 journal article
Hemoglobin exacerbates the ocular inflammatory response to endotoxin
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 234(10), 643–647.
TL;DR:
It is likely that hemoglobinic Fe is responsible for the increased infiltration of white cells caused by the co-injection of autologous hemaglobin and endotoxin, which was increased 15-fold.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1996 journal article
The effects of clinically relevant hyperthermic temperatures on the kinetic binding parameters of a monoclonal antibody
NUCLEAR MEDICINE AND BIOLOGY, 23(4), 551–557.
author keywords: monoclonal antibodies; hyperthermia; antibody binding kinetics; radiotherapy
MeSH headings : Animals; Antibodies, Monoclonal / metabolism; Antibodies, Monoclonal / pharmacokinetics; Dogs; Glioma / metabolism; Humans; Hyperthermia, Induced; Kinetics; Mice; Mice, Nude; Osteosarcoma / metabolism; Tumor Cells, Cultured
TL;DR:
The effects of clinically relevant levels of hyperthermia on the kinetic binding parameters were investigated for 81C6, an antibody undergoing Phase I/II clinical trials for the treatment of brain tumors and neoplastic meningitis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1996 journal article
Phase I evaluation of mitoxantrone alone and combined with whole body hyperthermia in dogs with lymphoma
INTERNATIONAL JOURNAL OF HYPERTHERMIA, 12(3), 309–320.
author keywords: hyperthermia; mitoxanthrone; lymphoma; canine
MeSH headings : Animals; Antineoplastic Agents / therapeutic use; Antineoplastic Agents / toxicity; Blood Cell Count / veterinary; Dogs; Female; Fever / veterinary; Lymphoma / metabolism; Lymphoma / therapy; Lymphoma / veterinary; Male; Mitoxantrone / therapeutic use; Mitoxantrone / toxicity; Neutropenia / complications; Neutropenia / veterinary; Neutrophils / metabolism; Regression Analysis; Thrombocytopenia / complications; Thrombocytopenia / veterinary
TL;DR:
It is concluded that MX may be administered without dose reduction to dogs undergoing WBH and that MX should be evaluated more thoroughly in future thermochemotherapy studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1996 journal article
Intravitreal transforming growth factor-beta 2 decreases cellular infiltration in endotoxin-induced ocular inflammation in rabbits
CURRENT EYE RESEARCH, 15(1), 95–103.
author keywords: inflammation; in situ hybridization; rabbits; transforming growth factor-beta (TGF-beta); uveitis; endotoxin
MeSH headings : Animals; Anterior Eye Segment / pathology; Body Fluids / metabolism; Cell Movement / drug effects; Injections; Interleukin-1 / metabolism; Lipopolysaccharides; Male; Rabbits; Transforming Growth Factor beta / pharmacology; Uveitis / chemically induced; Uveitis / metabolism; Uveitis / pathology; Vitreous Body
TL;DR:
In a rabbit model of LPS-induced uveitis, TGF-beta may interrupt the cascade of events leading to ocular inflammation, thereby suggesting therapeutic potential.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1996 journal article
An in vitro-in vivo validation of the isolated perfused tumor and skin flap preparation as a model of cisplatin delivery to tumors
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 35(3), 173–177.
author keywords: cisplatin; isolated perfused tumor and skin flap; isolated perfusion
MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / pharmacokinetics; Chemotherapy, Cancer, Regional Perfusion / methods; Cisplatin / administration & dosage; Cisplatin / pharmacokinetics; Drug Screening Assays, Antitumor; In Vitro Techniques; Injections, Intralesional; Neoplasms, Experimental / drug therapy; Neoplasms, Experimental / metabolism; Reproducibility of Results; Surgical Flaps; Swine
TL;DR:
Tissue Pt concentrations obtained following systemic administration of cisplatin (CDDP) to whole pigs bearing tumored skin flaps with data obtained from IPTSF treated similarly are compared to that obtained in vivo.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1996 journal article
In vitro percutaneous absorption of benzidine in complex mechanistically defined chemical mixtures
TOXICOLOGY AND APPLIED PHARMACOLOGY, 141(2), 497–506.
MeSH headings : Animals; Benzidines / pharmacokinetics; Benzidines / toxicity; Dimethyl Sulfoxide / pharmacology; Perfusion; Skin Absorption; Surface-Active Agents / pharmacology; Swine; Urinary Bladder Neoplasms / chemically induced
TL;DR:
It is proposed that chemical-chemical interactions between benzidine and SnCl2 may be inhibiting benzidine absorption and chemical-biological interactions between M + SL and skin may be enhancing Benzidine absorption.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1996 journal article
Risk factors associated with thrombocytopenia in horses
Journal of Veterinary Internal Medicine, 10, 127–132.
Source: NC State University Libraries
Added: August 6, 2018
1996 journal article
Reservoir competence of raccoons (Procyon lotor) for Borrelia burgdorferi
Journal of Wildlife Diseases, 32, 300–314.
Source: NC State University Libraries
Added: August 6, 2018
1996 journal article
Reservoir Competence of the Southeastern Five-Lined Skink (Eumeces inexpectatus) and the Green Anole (Anolis carolinensis) for Borrelia burgdorferi
The American Journal of Tropical Medicine and Hygiene, 54(1), 92–97.
MeSH headings : Animals; Borrelia burgdorferi Group / isolation & purification; Disease Reservoirs; Lizards / microbiology; Rabbits; Ticks / microbiology
TL;DR:
The ability of the lizards to sustain a Borrelia infection and infect attached ticks suggests that they may play a role in the maintenance of spirochete transmission.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
1996 journal article
Polymerase chain reaction evidence of ehrlichia chaffeensis, an agent of human ehrlichiosis, in dogs from Southeast Virginia
American Journal of Veterinary Research, 57, 1175–1179.
Source: NC State University Libraries
Added: August 6, 2018
1996 journal article
Pharmacokinetics and toxicity of oral and intravenous lonidamine in dogs
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 38(2), 129–135.
author keywords: lonidamine; pharmacokinetics; dog
MeSH headings : Administration, Oral; Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / blood; Antineoplastic Agents / pharmacokinetics; Antineoplastic Agents / toxicity; Dogs; Indazoles / administration & dosage; Indazoles / blood; Indazoles / pharmacokinetics; Indazoles / toxicity; Injections, Intravenous; Kinetics; Liver / drug effects; Liver / pathology; Male; Testis / drug effects; Testis / pathology; Vomiting / chemically induced
TL;DR:
The findings suggest that lonidamine is hepatotoxic in dogs, and the dose and route appears to be a viable and controllable method for prospective quantification of l onidamine interaction with systemic chemotherapy and/or hyperthermia.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1996 journal article
Use of the single cell gel electrophoresis assay (SCGE) for detection of oxidant-induced DNA single strand breaks (SSB) in human lung cells in vitro.
Toxicology and Applied Pharmacology, 141, 195–204.
MeSH headings : Bronchi / drug effects; Cells, Cultured; Cryopreservation; DNA Damage; DNA, Single-Stranded / drug effects; Electrophoresis / methods; Epithelium / drug effects; Humans; Hydrogen Peroxide / toxicity; Oxidants / toxicity; Ozone / toxicity
Source: NC State University Libraries
Added: August 6, 2018
1996 article
Tumor necrosis factor alpha (TNF alpha)-induced ICAM-1 surface expression in airway epithelial cells in vitro: Possible signal transduction mechanisms
CYTOKINES AND ADHESION MOLECULES IN LUNG INFLAMMATION, Vol. 796, pp. 30–37.
MeSH headings : Adult; Antigens, CD / metabolism; Antioxidants / pharmacology; Bronchi / cytology; Bronchi / metabolism; Cell Line; Epithelium / metabolism; Flow Cytometry; Humans; Intercellular Adhesion Molecule-1 / metabolism; Protein Kinase C / metabolism; Receptors, Tumor Necrosis Factor / metabolism; Receptors, Tumor Necrosis Factor, Type I; Signal Transduction; Tumor Necrosis Factor-alpha / pharmacology
TL;DR:
Results indicate that TNF alpha-induced ICAM-1 surface expression is a specific receptor-mediated response (TNF-R1), which is mediated by mechanisms dependent on PKC and intracellular reactive oxygen species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1996 journal article
The occurrence of an Ichthyobodo-like organism on captive Atlantic spadefish, Chaetodipterus faber (Broussonet)
JOURNAL OF FISH DISEASES, 19(1), 111–112.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
1996 journal article
Oxidant stress stimulates mucin secretion and PLG in airway epithelium via a nitric oxide-dependent mechanism
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 271(5), L854–L861.
author keywords: airway epithelial cells; second messengers; nitric oxide; phospholipase C
MeSH headings : Animals; Cell Transformation, Viral; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Epithelium / drug effects; Epithelium / physiology; Guinea Pigs; Humans; Hydrogen Peroxide / pharmacology; Molsidomine / analogs & derivatives; Molsidomine / pharmacology; Mucins / biosynthesis; Mucins / metabolism; Nitric Oxide / pharmacology; Penicillamine / analogs & derivatives; Penicillamine / pharmacology; Peroxides / pharmacology; Reactive Oxygen Species; S-Nitroso-N-Acetylpenicillamine; Superoxides / pharmacology; Trachea / physiology; Type C Phospholipases / metabolism; Xanthine Oxidase; omega-N-Methylarginine / pharmacology; tert-Butylhydroperoxide
TL;DR:
The results suggest that intracellularly generated radical species of nitrogen and oxygen may be important modulators of the response of airway epithelial cells to external oxidant stress.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1996 journal article
Nitric oxide synthase inhibitors exert differential time-dependent effects on LPS-induced uveitis
EXPERIMENTAL EYE RESEARCH, 62(1), 21–28.
author keywords: nitric oxide; uveitis; nitric oxide synthase; nitric oxide synthase inhibitors; inflammation
MeSH headings : Animals; Aqueous Humor / metabolism; Arginine / analogs & derivatives; Arginine / therapeutic use; Cell Count / drug effects; Dose-Response Relationship, Drug; Eye Proteins / drug effects; Guanidines / therapeutic use; Kinetics; Lipopolysaccharides; NG-Nitroarginine Methyl Ester; Nitric Oxide / antagonists & inhibitors; Nitric Oxide / physiology; Nitric Oxide Synthase / antagonists & inhibitors; Rabbits; Uveitis, Anterior / etiology; Uveitis, Anterior / metabolism; Uveitis, Anterior / prevention & control
TL;DR:
Investigation of the effects of NOS inhibitors with different NOS isoform specificities in the rabbit model of endotoxin-induced ocular inflammation suggests that cNOS may play a greater role in the earlier stages of this developing inflammatory response, and extends others' observations that NO is a key mediator in uveitis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1996 article
Environmental toxins induce intracellular responses of airway epithelium through reactive species of oxygen and nitrogen
Rochelle, L. G., Fischer, B. M., Krunkosky, T. M., Wright, D. T., & Adler, K. B. (1996, March). CHEST, Vol. 109, pp. S35–S39.
MeSH headings : Air Pollutants / adverse effects; Animals; Free Radicals / adverse effects; Humans; Nitrogen / adverse effects; Reactive Oxygen Species / adverse effects; Respiratory System / cytology; Respiratory System / drug effects
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1996 journal article
Effect of pertussis toxin and B-Oligomer on platelet-activating factor-induced generation of inositol phosphates in porcine alveolar macrophages.
American Journal of Veterinary Research, 57, 574–579.
Source: NC State University Libraries
Added: August 6, 2018
1996 journal article
An automated torsion balance for the investigation of microstructure of single filaments: Polypropylene
Journal of Applied Polymer Science, 61, 293–306.
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
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