Works Published in 2012
Displaying works 21 - 40 of 54 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2012 journal article
Flavonoid metabolism: the synthesis of phenolic glucuronides and sulfates as candidate metabolites for bioactivity studies of dietary flavonoids
Tetrahedron, 68(22), 4194–4201.
author keywords: Flavanoids; Metabolites; Phenolic glucuronides; Phenolic sulfates; Synthesis
TL;DR:
The synthesis of a series of phenolic glucuronide 1a–e and sulfate 2a-e derivates as candidate metabolites for use as reference compounds in metabolic profiling studies and for the exploration of flavonoid bioactivity are detailed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2012 journal article
Vascular bioactivity of anthocyanins and phenolic acid degradants: modulation of superoxide and nitric oxide
Proceedings of the Nutrition Society, 71(OCE2).
TL;DR:
Investigation of vascular bioactivity of selected anthocyanins and phenolic degradants, and potential synergy between flavonoids and ascorbic acid found superoxide was significantly decreased by protocatechuic acid in combination with two Flavonoids, epicatechin and quercetin, and asCorbic Acid; although to a lesser extent than with protocatechaic acid alone.
(via Semantic Scholar)
www.cambridge.org (publisher PDF)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2012 journal article
Dietary Flavonoids and Risk of Stroke in Women
Stroke, 43(4), 946–951.
author keywords: citrus fruits; flavanones; flavonoids; hemorrhagic; ischemic; polyphenols; stroke
MeSH headings : Adult; Brain Ischemia / epidemiology; Brain Ischemia / prevention & control; Citrus; Dietary Supplements; Female; Flavonoids / administration & dosage; Follow-Up Studies; Fruit; Humans; Incidence; Intracranial Hemorrhages / epidemiology; Intracranial Hemorrhages / prevention & control; Middle Aged; Retrospective Studies; Stroke / epidemiology; Stroke / prevention & control; Surveys and Questionnaires; United States; United States Department of Agriculture
TL;DR:
Citrus fruit consumption may be associated with a reduction in stroke risk, and experimental data support these epidemiological associations that the flavanone content of citrus fruits may potentially be cardioprotective.
(via Semantic Scholar)
Source: Crossref
Added: January 5, 2020
2012 journal article
The impact of human metabolism on the bioactivity of anthocyanins
Proceedings of the Nutrition Society, 71(OCE2).
TL;DR:
This work explored the bioactivity ofthese metabolites on vascular health by measuring the effects on mediators of nitric oxide bioavailability including endothelial nitric oxidesynthase (eNOS), NADPH oxidase (NOX4) and superoxide.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: November 13, 2019
2012 journal article
Relative impact of flavonoid composition, dose and structure on vascular function: a systematic review of randomised controlled trials of flavonoid-rich food products
Molecular Nutrition & Food Research, 56(11), 1605–1616.
Source: ORCID
Added: November 13, 2019
2012 journal article
Investigating the bioavailability of anthocyanin metabolites
Proceedings of the Nutrition Society, 71(OCE2).
TL;DR:
Clinical samples from a 12-week anthocyanin intervention where 52 postmenopausal females were fed 500 mg/day elderberry extract were analysed and nine metabolites were identified, including nine currently unidentified metabolites which are the focus of future investigation.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: November 13, 2019
2012 journal article
Higher anthocyanin intake is associated with lower arterial stiffness and central blood pressure in women--
The American Journal of Clinical Nutrition, 96(4), 781–788.
Source: ORCID
Added: November 13, 2019
2012 journal article
Diets Containing Pistachios Reduce Systolic Blood Pressure and Peripheral Vascular Responses to Stress in Adults With Dyslipidemia
Hypertension, 60(1), 58–63.
author keywords: diet; stress; blood pressure; endothelium; total peripheral resistance; nuts; pistachios
MeSH headings : Adult; Blood Pressure / physiology; Brachial Artery / diagnostic imaging; Brachial Artery / physiopathology; Cardiac Output / physiology; Cross-Over Studies; Diet, Fat-Restricted / methods; Dose-Response Relationship, Drug; Dyslipidemias / physiopathology; Fasting; Heart Rate / physiology; Humans; Outcome Assessment, Health Care; Pistacia; Stress, Physiological / physiology; Ultrasonography; Vascular Resistance / physiology
TL;DR:
Reductions in peripheral vascular constriction and the resulting decrease in hemodynamic load may be important contributors to lower risk in nut consumers.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: November 13, 2019
2012 journal article
Effect of cyanidin-glucoside and its metabolites on inflammatory biomarkers of vascular function
Proceedings of the Nutrition Society, 71(OCE2).
TL;DR:
The ability of cyanidin-glucoside (C3G), the most abundant dietary anthocyanin, and its metabolites to modulate the expression of CAMs and cytokines in cultured human umbilical vein endothelial cells (HUVECs) challenged with either CD40L or oxLDL is investigated.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: November 13, 2019
2012 journal article
Effects of chocolate, cocoa, and flavan-3-ols on cardiovascular health: a systematic review and meta-analysis of randomized trials--
The American Journal of Clinical Nutrition, 95(3), 740–751.
Source: ORCID
Added: November 13, 2019
2012 journal article
Dietary flavonoids and risk of stroke in women
Stroke, STROKEAHA-111.
Source: ORCID
Added: November 13, 2019
2012 article
Plant-Derived Antibodies for Academic, Industrial, and Therapeutic Applications
Komarnytsky, S., & Borisjuk, N. (2012, April). Antibody-Mediated Drug Delivery Systems, pp. 365–381.
TL;DR:
This work reports the discovery of restriction enzymes that digest DNA at well-defined locations and the combination of restriction digestion and ligation of the DNA fragments that created the first recombinant DNA in 1972.
(via Semantic Scholar)
Source: ORCID
Added: November 11, 2019
2012 journal article
Active DNA Demethylation in Plant Companion Cells Reinforces Transposon Methylation in Gametes
Science, 337(6100), 1360–1364.
MeSH headings : Arabidopsis / cytology; Arabidopsis / genetics; Arabidopsis Proteins / genetics; Arabidopsis Proteins / metabolism; DNA Methylation; DNA Transposable Elements / genetics; DNA, Plant / metabolism; Endosperm / cytology; Endosperm / genetics; Gene Expression Regulation, Plant; Gene Silencing; Germ Cells, Plant / metabolism; N-Glycosyl Hydrolases / genetics; N-Glycosyl Hydrolases / metabolism; RNA, Plant / metabolism; Trans-Activators / genetics; Trans-Activators / metabolism
TL;DR:
It is demonstrated that demethylation in companion cells reinforces transposon methylation in plant gametes and likely contributes to stable silencing of transposable elements across generations.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2012 journal article
The formation, occurrence and function of b-apocarotenoids: b-Carotene metabolites that may modulate nuclear receptor signaling
American Journal of Clinical Nutrition, 96, 1189–1192.
MeSH headings : Animals; Carotenoids / metabolism; Food; Mice; Receptors, Cytoplasmic and Nuclear / metabolism; Receptors, Retinoic Acid / antagonists & inhibitors; Receptors, Retinoic Acid / metabolism; Signal Transduction; Transcriptional Activation; Tretinoin / metabolism; beta Carotene / metabolism
TL;DR:
The findings suggest that a possible biological function of β-apocarotenoids is their ability to interfere with nuclear receptor signaling.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 8, 2019
2012 journal article
Naturally-occurring eccentric cleavage products of provitamin A carotene b-carotene function as antagonists of retinoic acid receptors
Journal of Biological Chemistry, 287, 15886–158995.
MeSH headings : Animals; Binding, Competitive; COS Cells; Carotenoids / chemistry; Carotenoids / metabolism; Carotenoids / pharmacology; Chlorocebus aethiops; Cytochrome P-450 Enzyme System; Gene Expression / drug effects; Hep G2 Cells; Humans; Models, Molecular; Molecular Structure; Radioligand Assay; Receptors, Retinoic Acid / antagonists & inhibitors; Receptors, Retinoic Acid / genetics; Receptors, Retinoic Acid / metabolism; Retinoic Acid 4-Hydroxylase; Reverse Transcriptase Polymerase Chain Reaction; Transcriptional Activation / drug effects; Tretinoin / metabolism; Tretinoin / pharmacology; Tritium; beta Carotene / chemistry; beta Carotene / metabolism
TL;DR:
Findings suggest that β-apocarotenoids function as naturally occurring retinoid receptor antagonists, which may have implications for the activities of dietary β-carotene as a provitamin A and as a modulator of risk for cardiovascular disease and cancer.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 8, 2019
2012 journal article
Watermelon: From dessert to functional food
Israel Journal of Plant Sciences, 60(4), 395–402.
Source: NC State University Libraries
Added: August 6, 2018
2012 conference paper
Seeking novel Leishmanicidal natural products from common medicinal plants, the example of Eryngium foetidum L
Planta Medica, 78(11), 1132–1132.
Source: NC State University Libraries
Added: August 6, 2018
2012 conference paper
Modulation of muscle mass and myogenic stem cells with natural products
Planta Medica, 78(11), 1096–1096.
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
In vivo and in vitro antidiabetic effects of aqueous cinnamon extract and cinnamon polyphenol-enhanced food matrix
FOOD CHEMISTRY, 135(4), 2994–3002.
author keywords: Cinnamomum burmannii; Cinnamon; Diabetes; Fasting blood glucose; Glucose production
MeSH headings : Animals; Cell Line; Cinnamomum zeylanicum / chemistry; Diabetes Mellitus, Type 2 / drug therapy; Diabetes Mellitus, Type 2 / enzymology; Diabetes Mellitus, Type 2 / genetics; Diabetes Mellitus, Type 2 / metabolism; Glucose / metabolism; Glucose-6-Phosphatase / genetics; Glucose-6-Phosphatase / metabolism; Humans; Hypoglycemic Agents / administration & dosage; Hypoglycemic Agents / pharmacology; Male; Mice; Mice, Inbred C57BL; Phosphoenolpyruvate Carboxykinase (ATP) / genetics; Phosphoenolpyruvate Carboxykinase (ATP) / metabolism; Plant Extracts / administration & dosage; Plant Extracts / pharmacology; Polyphenols / administration & dosage; Polyphenols / pharmacology; Rats; Soy Foods / analysis
TL;DR:
CE and cinnamon polyphenol-enriched defatted soy flour (CDSF) were effective in acutely lowering fasting blood glucose levels in diet induced obese hyperglycemic mice at 300 and 600 mg/kg, respectively.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 conference paper
Cucurbitacin glycosides from Datisca glomerata with antiplasmodial activity
Planta Medica, 78(11), 1245–1245.
Source: NC State University Libraries
Added: August 6, 2018
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