Works Published in 2015

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Displaying works 21 - 40 of 69 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2015 journal article

Synthesis and Quantitative Analysis of Plasma-Targeted Metabolites of Catechin and Epicatechin

Journal of Agricultural and Food Chemistry, 63(8), 2233–2240.

By: J. Blount*, B. Redan*, M. Ferruzzi*, B. Reuhs*, B. Cooper*, J. Harwood*, V. Shulaev*, G. Pasinetti*, R. Dixon*

author keywords: catechin; glucuronosylation; O-methylation; phase II metabolites; semisynthesis; structure determination; two-site validation
MeSH headings : Animals; Catechin / blood; Catechin / chemical synthesis; Catechin / metabolism; Grape Seed Extract / blood; Grape Seed Extract / chemical synthesis; Grape Seed Extract / metabolism; Rats
TL;DR: These studies provide a basis for improvements in future work on the bioavailability, metabolism, and mechanism of action of metabolites derived from dietary flavan-3-ols in a range of interventions. (via Semantic Scholar)
Source: Crossref
Added: February 24, 2020

2015 journal article

Dietary Phenolic Compounds Selectively Inhibit the Individual Subunits of Maltase-Glucoamylase and Sucrase-Isomaltase with the Potential of Modulating Glucose Release

Journal of Agricultural and Food Chemistry, 63(15), 3873–3879.

By: M. Simsek*, R. Quezada-Calvillo*, M. Ferruzzi*, B. Nichols* & B. Hamaker*

author keywords: alpha-glucosidases; inhibition; maltase-glucoamylase; phenolics; sucrase-isomaltase
MeSH headings : Animals; Digestion; Enzyme Inhibitors / chemistry; Enzyme Inhibitors / metabolism; Glucan 1,4-alpha-Glucosidase / chemistry; Glucan 1,4-alpha-Glucosidase / metabolism; Glucose / chemistry; Humans; Kinetics; Mice; Oligo-1,6-Glucosidase / chemistry; Oligo-1,6-Glucosidase / metabolism; Phenol / chemistry; Phenol / metabolism; Sucrase / chemistry; Sucrase / metabolism; alpha-Glucosidases / chemistry; alpha-Glucosidases / metabolism
TL;DR: Inhibition of fast-digesting Ct-MGAM and Ct-SI by EGCG and chlorogenic acid could lead to a slow, but complete, digestion of starch for improved glycemic response of starchy foods with potential health benefit. (via Semantic Scholar)
Source: Crossref
Added: February 24, 2020

2015 journal article

Microwave-assisted extraction of lycopene in tomato peels: Effect of extraction conditions on all-trans and cis-isomer yields

LWT - Food Science and Technology, 62(1), 160–168.

By: K. Ho*, M. Ferruzzi*, A. Liceaga* & M. San Martín-González*

author keywords: All-trans-lycopene; Cis-isomers; Microwave-assisted extraction; Response surface methodology
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: Crossref
Added: February 24, 2020

2015 journal article

Correction to Survey of Polyphenol Constituents in Grapes and Grape-Derived Products

Journal of Agricultural and Food Chemistry, 63(14), 3804–3804.

By: Y. Xu, J. Simon, C. Welch, J. Wightman, M. Ferruzzi*, L. Ho, G. Pasinetti, Q. Wu

TL;DR: The author states that Giulio M. Pasinetti holds a Career Scientist Award in the Research and Development unit and is the Director of the Basic and Biomedical Research and Training Program, GRECC, James J. Peters Veterans Affairs Medical Center. (via Semantic Scholar)
Source: Crossref
Added: February 24, 2020

2015 journal article

Influence of molecular weight on intracellular antioxidant activity of invasive silver carp ( Hypophthalmichthys molitrix ) protein hydrolysates

Journal of Functional Foods, 18, 1158–1166.

By: S. Malaypally*, A. Liceaga*, K. Kim*, M. Ferruzzi*, F. Martin* & R. Goforth*

author keywords: Protein hydrolysates; Intracellular antioxidant activity; Molecular weight; Peptide sequence
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: Crossref
Added: February 24, 2020

2015 journal article

Thermal degradation of green tea flavan-3-ols and formation of hetero- and homocatechin dimers in model dairy beverages

Food Chemistry, 173, 305–312.

By: B. Song*, C. Manganais* & M. Ferruzzi*

author keywords: Flavan-3-ols; Thermal stability; Oxidation; Theasinesin; P-2 dimer; Protein-polyphenol interaction
MeSH headings : Animals; Beverages / analysis; Catechin / analogs & derivatives; Catechin / analysis; Dietary Proteins / analysis; Flavonoids / chemistry; Food Handling / methods; Milk / chemistry; Polyphenols / analysis; Tea / chemistry
TL;DR: The results suggest that protein interactions may be useful in stabilising flavan-3-ols through thermal processing, and the presence of galloyl and hydroxy moieties was associated with higher stability of monomeric flavan 3-ols with increasing protein concentrations, suggesting potential for protein affinity to stabilise flavan -3-ol to thermal treatment. (via Semantic Scholar)
Source: Crossref
Added: February 24, 2020

2015 journal article

Chemical investigation of commercial grape seed derived products to assess quality and detect adulteration

Food Chemistry, 170, 271–280.

By: T. Villani*, W. Reichert*, M. Ferruzzi*, G. Pasinetti*, J. Simon* & Q. Wu*

author keywords: Grape seed extract; LC-MS; Polyphenol; Proanthocyanidins; Adulteration; Quality control
MeSH headings : Antioxidants / analysis; Chromatography, Liquid / methods; Food Contamination; Grape Seed Extract / chemistry; Mass Spectrometry / methods; Plant Extracts / chemistry; Polyphenols / analysis; Quality Control; Seeds / chemistry; Vitis / chemistry
TL;DR: A TLC method was developed to allow for rapid and inexpensive detection of adulteration in GSE by peanut skin, demonstrating the need for development of quality control standards for GSE. (via Semantic Scholar)
Source: Crossref
Added: February 24, 2020

2015 journal article

Plasma bioavailability and regional brain distribution of polyphenols from apple/grape seed and bilberry extracts in a young swine model

Molecular Nutrition & Food Research, 59(12), 2432–2447.

By: T. Chen*, J. Kritchevsky*, K. Hargett*, K. Feller*, R. Klobusnik*, B. Song*, B. Cooper*, Z. Jouni*, M. Ferruzzi*, E. Janle*

author keywords: Anthocyanins; Brain distribution; Catechins; Pharmacokinetics; Polyphenols
MeSH headings : Animals; Anthocyanins / metabolism; Anthocyanins / pharmacokinetics; Biological Availability; Body Weight / drug effects; Brain / drug effects; Brain / metabolism; Dose-Response Relationship, Drug; Eating / drug effects; Grape Seed Extract / chemistry; Liver / drug effects; Liver / enzymology; Malus / chemistry; Plant Extracts / chemistry; Polyphenols / blood; Polyphenols / pharmacokinetics; Polyphenols / urine; Sus scrofa; Tissue Distribution; Vaccinium myrtillus / chemistry; Vitis / chemistry; Weaning
TL;DR: Significant plasma dose-dependence was observed in flavan-3-ol metabolites of the AGSE group and in Mal, Del and Cyn galactosides and Pet, Peo, and Cyn glucosides of the bilberry groups. (via Semantic Scholar)
Source: Crossref
Added: February 24, 2020

2015 journal article

Method to harness bioactive secondary metabolites from intact Quinoa seeds with implications for chronic disease prevention

Planta Medica, 81(11).

By: B. Graf*, A. Poulev*, P. Kuhn*, D. Esposito n, M. Lila n & I. Raskin*

Sources: Crossref, NC State University Libraries
Added: February 21, 2020

2015 journal article

Anthocyanins and their physiologically relevant metabolites alter the expression of IL-6 and VCAM-1 in CD40L and oxidized LDL challenged vascular endothelial cells

Molecular Nutrition & Food Research, 59(6), 1095–1106.

By: H. Amin*, C. Czank*, S. Raheem*, Q. Zhang*, N. Botting*, A. Cassidy*, C. Kay*

author keywords: Adhesion molecule; Cytokine; Cyanidin-3-glucoside; Inflammation; Metabolites
MeSH headings : Anthocyanins / pharmacology; CD40 Ligand / metabolism; Coumaric Acids / metabolism; Endothelial Cells / cytology; Endothelial Cells / drug effects; Endothelial Cells / metabolism; Gene Expression; Glucosides / pharmacology; Glucuronides / metabolism; Human Umbilical Vein Endothelial Cells; Humans; Hydroxybenzoates / metabolism; Interleukin-6 / genetics; Interleukin-6 / metabolism; Lipoproteins, LDL / metabolism; RNA, Messenger / genetics; RNA, Messenger / metabolism; Vascular Cell Adhesion Molecule-1 / genetics; Vascular Cell Adhesion Molecule-1 / metabolism
TL;DR: Novel data are provided to suggest that anthocyanin metabolites are bioactive at physiologically relevant concentrations and have the potential to modulate cardiovascular disease progression by altering the expression of inflammatory mediators. (via Semantic Scholar)
Source: Crossref
Added: February 9, 2020

2015 journal article

Flavonoid metabolites reduce tumor necrosis factor-α secretion to a greater extent than their precursor compounds in human THP-1 monocytes

Molecular Nutrition & Food Research, 59(6), 1143–1154.

By: J. di Gesso*, J. Kerr*, Q. Zhang*, S. Raheem*, S. Yalamanchili*, D. O'Hagan*, C. Kay*, M. O'Connell*

author keywords: Cytokine; Inflammation; Metabolism; Phase 2 conjugates; Polyphenol
MeSH headings : Cell Line; Cell Survival / drug effects; Flavonoids / chemistry; Flavonoids / pharmacology; Humans; Hydroxybenzoates / pharmacology; Interleukin-10 / metabolism; Interleukin-1beta / metabolism; Lipopolysaccharides / adverse effects; Monocytes / drug effects; NF-kappa B / genetics; NF-kappa B / metabolism; Parabens / pharmacology; RNA, Messenger / genetics; RNA, Messenger / metabolism; Tumor Necrosis Factor-alpha / metabolism
TL;DR: Novel evidence suggesting flavonoid bioactivity results from cumulative or additive effects of circulating metabolites is provided, suggesting singular or additive anti‐inflammatory effects of flavonoids relative to their precursor structures. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020

2015 journal article

Rethinking paradigms for studying mechanisms of action of plant bioactives

Nutrition Bulletin, 40(4), 335–339.

By: C. Kay*

author keywords: anti-inflammatory; bioactivity flavonoid; metabolism; microflora; vascular
TL;DR: Recent research suggests a highly complex interplay between metabolism, intestinal microflora, the immune system and various tissues of the authors' body, which suggests protection against cardio-metabolic diseases and disorders. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020

2015 book

Effective waste water treatment and its management

In Toxicity and Waste Management Using Bioremediation (pp. 312–334).

By: S. Prabu*, T. Suriyaprakash, R. Kandasamy* & T. Rathinasabapathy*

Contributors: S. Prabu*, T. Suriyaprakash, R. Kandasamy* & T. Rathinasabapathy*

UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: ORCID
Added: December 9, 2019

2015 journal article

Orange juice--derived flavanone and phenolic metabolites do not acutely affect cardiovascular risk biomarkers: a randomized, placebo-controlled, crossover trial in men at moderate risk of cardiovascular disease--

The American Journal of Clinical Nutrition, 101(5), 931–938.

Colin Kay

Source: ORCID
Added: November 13, 2019

2015 journal article

Phenolic Metabolites of Anthocyanins Modulate Mechanisms of Endothelial Function

Journal of Agricultural and Food Chemistry, 63(9), 2423–2431.

By: M. Edwards*, C. Czank*, G. Woodward*, A. Cassidy* & C. Kay*

author keywords: endothelium; eNOS; cyanidin; HUVEC; NADPH-oxidase
MeSH headings : Anthocyanins / metabolism; Cell Line; Human Umbilical Vein Endothelial Cells / metabolism; Humans; Nitric Oxide / metabolism; Nitric Oxide Synthase Type III / metabolism; Phenols / metabolism; Superoxides / metabolism
TL;DR: Anthocyanin metabolites may modulate vascular reactivity by inducing HO-1 and modulating NOX activity, resulting in reduced superoxide production and improved NO bioavailability. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Crossref, ORCID
Added: November 13, 2019

2015 journal article

Anthocyanins and their physiologically relevant metabolites alter the expression of IL-6 and VCAM-1 in CD40L and oxidized LDL challenged vascular endothelial cells

Molecular Nutrition & Food Research, 59(6), 1095–1106.

Colin Kay

Source: ORCID
Added: November 13, 2019

2015 journal article

Neuroprotective effects of dried camu-camu (Myrciaria dubia HBK McVaugh) residue in C. elegans

Food Research International.

By: J. Azevêdo*, K. Borges*, M. Genovese*, R. Correia* & D. Vattem*

author keywords: Camu-camu; Neurodegeneration; Life span; Alzheimer's disease; Parkinson's disease
TL;DR: Results suggest a significant upregulation expression of superoxide dismutase and catalases andCatalases in response to treatment with camu-camu residue significantly extended the life span in C. elegans by 20% and delayed Aβ 1–42 induced paralysis by 21%. (via Semantic Scholar)
Source: ORCID
Added: November 12, 2019

2015 journal article

Caprine frozen yoghurt produced with fresh and spray dried jambolan fruit pulp (Eugenia jambolana Lam) and Bifidobacterium animalis subsp. lactis BI-07

LWT - Food Science and Technology, 62(2), 1099–1104.

author keywords: Goat milk; Dairy; Bioactive compounds; Probiotic
TL;DR: The caprine frozen yoghurt enriched with jambolan fruit proved to be an efficient carrier for B. animalis subsp. (via Semantic Scholar)
Source: ORCID
Added: November 12, 2019

2015 journal article

Potentially probiotic ice cream from goat's milk: Characterization and cell viability during processing, storage and simulated gastrointestinal conditions

LWT - Food Science and Technology.

By: P. Silva*, M. Fátima Bezerra*, K. Santos* & R. Correia*

author keywords: Goat's milk; Ice cream; Probiotic survival; Gastrointestinal simulation
TL;DR: Research shows that goat's milk ice cream is an adequate delivery vehicle for the probiotic bacteria B. animalis and its effects on physicochemical characteristics, meltdown behavior and sensory properties are shown. (via Semantic Scholar)
Source: ORCID
Added: November 12, 2019

2015 journal article

Flavonoids and gastroprotective effect of matricaria chamomilla against indomethacin-induced ulcer in rats

Journal of Herbs, Spices and Medicinal Plants, 21(2), 111–117.

By: S. El Souda*, K. Ahmed*, M. Grace*, E. Elkherassy*, A. Farrag* & S. Abdelwahab*

Contributors: S. El Souda*, K. Ahmed*, M. Grace*, E. Elkherassy*, A. Farrag* & S. Abdelwahab*

TL;DR: The antiulcer effect of Matricaria chamomilla flower head extracts were investigated on indomethacin-induced ulcer models in rats and the highest percent of inhibition was shown by the ethyl acetate and chloroform fractions. (via Semantic Scholar)
Source: ORCID
Added: November 12, 2019

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