Works Published in 2012
Displaying works 41 - 54 of 54 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2012 journal article
Hypoglycemic effects of brassinosteroid in diet-induced obese mice
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 303(5), E652–E658.
author keywords: homobrassinolide; glucose; insulin resistance; diabetes; phosphoenolpyruvate carboxykinase
MeSH headings : AMP-Activated Protein Kinases / metabolism; Animals; Brassinosteroids / administration & dosage; Brassinosteroids / therapeutic use; Cell Line; Cyclic AMP / antagonists & inhibitors; Cyclic AMP / metabolism; Diet, High-Fat / adverse effects; Dietary Supplements; Gene Expression Regulation; Glucose-6-Phosphatase / genetics; Glucose-6-Phosphatase / metabolism; Hyperglycemia / prevention & control; Hypoglycemic Agents / therapeutic use; Insulin Resistance; Liver / enzymology; Liver / metabolism; Male; Mice; Mice, Inbred C57BL; Obesity / blood; Obesity / diet therapy; Obesity / etiology; Phosphoenolpyruvate Carboxykinase (ATP) / genetics; Phosphoenolpyruvate Carboxykinase (ATP) / metabolism; Phosphorylation; Protein Processing, Post-Translational; RNA, Messenger / metabolism; Random Allocation
TL;DR:
The results indicate the antidiabetic effects of brassinosteroids and begin to elucidate their putative cellular targets both in vitro and in vivo.
(via Semantic Scholar)
europepmc.org (repository)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
3. Good Health and Well-being
(OpenAlex)
13. Climate Action
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2012 journal article
Comparison of Health-Relevant Flavonoids in Commonly Consumed Cranberry Products
JOURNAL OF FOOD SCIENCE, 77(8), H176–H183.
Contributors: M. Grace n , A. Massey n, F. Mbeunkui n, G. Yousef n & M. Lila n
author keywords: anthocyanins; cranberry; flavonoids; proanthocyanidins; processing
MeSH headings : Anthocyanins / analysis; Beverages; Biflavonoids / analysis; Catechin / analysis; Chromatography, High Pressure Liquid; Flavonoids / analysis; Food Handling / methods; Freeze Drying; Fruit / chemistry; Plant Extracts / analysis; Proanthocyanidins / analysis; Vaccinium macrocarpon / chemistry
TL;DR:
As cranberry juices and other products are increasingly consumed for their recognized health benefits (including prophylaxis against urinary tract infection), it is relevant to consider how various degrees of commercial and home processing can alter innate levels of the biologically active flavonoids characteristic to the intact fruits.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2012 journal article
Biochemical Analysis and in Vivo Hypoglycemic Activity of a Grape Polyphenol-Soybean Flour Complex
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 60(36), 8860–8865.
author keywords: Concord grape juice; defatted soy flour; anthocyanins; proanthocyanidins; polyphenols; hypoglycemic; diabetes
MeSH headings : Adsorption; Animals; Blood Glucose / metabolism; Flour / analysis; Humans; Hydrogen-Ion Concentration; Hyperglycemia / drug therapy; Hyperglycemia / metabolism; Hypoglycemic Agents / administration & dosage; Hypoglycemic Agents / chemistry; Male; Mice; Mice, Inbred C57BL; Polyphenols / administration & dosage; Polyphenols / chemistry; Soybeans / chemistry; Vitis / chemistry
TL;DR:
Grape polyphenol-enriched DSF can provide a high-protein, low-sugar ingredient for delivery of concentrated grape polyphenolics and was able to significantly lower blood glucose levels in hyperglycemic C57BL/6J mice.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2012 journal article
Antiplasmodial activity of the ethnobotanical plant Cassia fistula
Natural Product Communications, 7(10), 1263–1266. http://www.scopus.com/inward/record.url?eid=2-s2.0-84869831873&partnerID=MN8TOARS
Sources: NC State University Libraries, ORCID
Added: August 6, 2018
2012 journal article
Isolation and characterization of flavonols from blackcurrant by high-performance counter-current chromatography and electrospray ionization tandem mass spectrometry
JOURNAL OF SEPARATION SCIENCE, 35(13), 1682–1689.
Contributors: F. Mbeunkui*, M. Grace* , G. Yousef* & M. Ann Lila n
author keywords: Blackcurrant (Ribes nigrum); Flavonols; High-performance counter-current chromatography; Liquid chromatography with tandem mass spectrometry
MeSH headings : Countercurrent Distribution / methods; Flavonols / chemistry; Flavonols / isolation & purification; Plant Extracts / chemistry; Plant Extracts / isolation & purification; Ribes / chemistry; Spectrometry, Mass, Electrospray Ionization / methods
TL;DR:
The results of these experiments demonstrated that high-performance counter-current chromatography along with ESI-MS(n) is a sensitive, selective, and effective technology for isolation and characterization of minor constituents from a complex mixture.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2012 journal article
Simultaneous extraction and quantitation of carotenoids, chlorophylls, and tocopherols in brassica vegetables
Journal of Agricultural and Food Chemistry, 60(29), 7238–7244.
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
Antiparasitic compounds from Cornus florida L. with activities against Plasmodium falciparum and Leishmania tarentolae
JOURNAL OF ETHNOPHARMACOLOGY, 142(2), 456–461.
Contributors: R. Graziose*, P. Rojas-Silva *, T. Rathinasabapathy* , C. Dekock*, M. Grace n , A. Poulev*, M. Ann Lila n, P. Smith*, I. Raskin *
author keywords: Cornus; Antiplasmodial; Antileishmanial; Malaria; Cytotoxicity; Triterpene; Betulinic acid
MeSH headings : Animals; Antimalarials / isolation & purification; Antimalarials / pharmacology; Cell Line; Cornus / chemistry; Inhibitory Concentration 50; Leishmania / drug effects; Leishmaniasis / drug therapy; Muscle, Skeletal / drug effects; Myoblasts / drug effects; Phytotherapy; Plant Bark; Plant Extracts / chemistry; Plant Extracts / pharmacology; Plant Extracts / therapeutic use; Plasmodium falciparum / drug effects; Rats; Trypanocidal Agents / isolation & purification; Trypanocidal Agents / pharmacology; Trypanocidal Agents / therapeutic use
TL;DR:
The compounds isolated in this study, while displaying moderate in vitro antiplasmodial activity, do not fully support the historical importance of C. florida as an antimalarial remedy in North America.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2012 journal article
Antiamnesic effects of ethyl acetate fraction from chestnut (Castanea crenata var. dulcis) inner skin on A beta(25-35)-induced cognitive deficits in mice
Journal of Medicinal Food, 15(12), 1051–1056.
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
Isolation and structural elucidation of indole alkaloids from Geissospermum vellosii by mass spectrometry
Journal of Chromatography B, 885-886, 83–89.
Contributors: F. Mbeunkui*, M. Grace* & M. Lila*
author keywords: Electrospray ionization tandem mass spectrometry; High performance counter-current chromatography; Indole alkaloids; Structural elucidation
MeSH headings : Apocynaceae / chemistry; Chromatography, High Pressure Liquid / methods; Countercurrent Distribution / methods; Indole Alkaloids / chemistry; Indole Alkaloids / isolation & purification; Molecular Conformation; Plant Bark / chemistry; Spectrometry, Mass, Electrospray Ionization / methods; Tandem Mass Spectrometry / methods
TL;DR:
The results of the experiments demonstrated that the combination of high performance counter current chromatography and ESI-MS(n) is a sensitive, selective and effective approach for rapid isolation and characterization of alkaloids from G. vellosii.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2012 journal article
In vitro antiplasmodial activity of indole alkaloids from the stem bark of Geissospermum vellosii
JOURNAL OF ETHNOPHARMACOLOGY, 139(2), 471–477.
Contributors: F. Mbeunkui n, M. Grace n , C. Lategan*, P. Smith*, I. Raskin * & M. Lila n
author keywords: Geissospermum vellosii; Apocynaceae; Indole alkaloids; Antiplasmodial activity; Malaria
MeSH headings : Animals; Antimalarials / chemistry; Antimalarials / isolation & purification; Antimalarials / pharmacology; Antimalarials / toxicity; Apocynaceae / chemistry; CHO Cells; Cell Survival / drug effects; Chromatography, High Pressure Liquid; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Indole Alkaloids / chemistry; Indole Alkaloids / isolation & purification; Indole Alkaloids / pharmacology; Indole Alkaloids / toxicity; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Parasitic Sensitivity Tests; Plant Bark; Plants, Medicinal; Plasmodium falciparum / drug effects
TL;DR:
Evidence is provided to support the use of Geissospermum vellosii as an antimalarial agent, as used by the native populations, as part of the ongoing investigations of new bioactive compounds with activity against malaria parasites.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2012 journal article
Complementary Approaches To Gauge the Bioavailability and Distribution of Ingested Berry Polyphenolics
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 60(23), 5763–5771.
Contributors: M. Lila n , D. Ribnicky*, L. Rojo *, P. Rojas-Silva *, A. Oren*, R. Havenaar*, E. Janle*, I. Raskin *, G. Yousef n, M. Grace n
author keywords: bioavailability; bioaccessibility; radiolabeling; artificial gastrointestinal tract
MeSH headings : Absorption; Animals; Anthocyanins / analysis; Anthocyanins / pharmacokinetics; Biological Availability; Blueberry Plants / chemistry; Carbon Isotopes / analysis; Carbon Isotopes / pharmacokinetics; Cell Line; Computer Simulation; Fruit / chemistry; Gastrointestinal Tract / drug effects; Gastrointestinal Tract / metabolism; Humans; Models, Biological; Phytochemicals / analysis; Phytochemicals / pharmacokinetics; Polyphenols / analysis; Polyphenols / pharmacokinetics; Rats; Vitis / chemistry
TL;DR:
Two different strategies for investigating the likely fate, after ingestion, of natural, bioactive berry constituents (anthocyanins and other non-nutritive flavonoids) are compared.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2012 journal article
Comparison of Flavonoid Composition of Red Raspberries (Rubus idaeus L.) Grown in the Southern United States
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 60(23), 5779–5786.
author keywords: raspberries; Rubus idaeus; anthocyanins; antioxidant capacity; FRAP; LC-MS; LC-TOF-MS; phenolics; flavonoids; PCA; targeted metabolite profiling
MeSH headings : Anthocyanins / chemistry; Antioxidants / analysis; Chromatography, High Pressure Liquid; Fruit / chemistry; Mass Spectrometry; Metabolomics; North Carolina; Phenols / chemistry; Rosaceae / chemistry; Seasons
TL;DR:
Variation in flavonoid composition was primarily attributed to genotype and associated with night temperature and hours exposed to temperatures over 29 °C and 'Nantahala' had particularly high levels of cyanidin-3-sambubioside, indicative of its purple raspberry lineage.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Efficient sorption of polyphenols to soybean flour enables natural fortification of foods
Food Chemistry, 131(4), 1193–1200.
Contributors: D. Roopchand *, M. Grace n , P. Kuhn *, D. Cheng*, N. Plundrich n, A. Poulev*, A. Howell *, B. Fridlender*, M. Lila n , I. Raskin *
TL;DR:
It is demonstrated that defatted soybean flour (DSF) can sorb polyphenols from blueberry and cranberry juices while separating them from sugars, providing a means to create protein-rich food ingredients containing concentrated plant bioactives without excess sugars, fats and water that can be incorporated in a variety of scientifically validated functional foods and dietary supplements.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: NC State University Libraries, ORCID
Added: August 6, 2018
2012 journal article
In vitro and in vivo anti-diabetic effects of anthocyanins from Maqui Berry (Aristotelia chilensis)
Food Chemistry, 131(2), 387–396.
Contributors: L. Rojo *, D. Ribnicky*, S. Logendra*, A. Poulev*, P. Rojas-Silva *, P. Kuhn *, R. Dorn*, M. Grace n , M. Lila n , I. Raskin *
author keywords: Dietary anthocyanins; Metabolic syndrome; Glucose metabolism; Maqui Berry
TL;DR:
It is observed that oral administration of ANC improved fasting blood glucose levels and glucose tolerance in hyperglycaemic obese C57BL/6J mice fed a high fat diet and D3S5G also increased glucose uptake in L6 myotubes and is at least partially responsible for ANC's anti-diabetic properties.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, ORCID, Web Of Science
Added: August 6, 2018
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