Works Published in 2014
Displaying works 41 - 60 of 60 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2014 journal article
Cytotoxic Effects of Ellagitannins Isolated from Walnuts in Human Cancer Cells
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 66(8), 1304–1314.
Contributors: V. Le*, D. Esposito n , M. Grace n , D. Ha*, A. Pham*, A. Bortolazzo*, Z. Bevens*, J. Kim *
MeSH headings : 3T3 Cells; Animals; Apoptosis / drug effects; Cell Line, Tumor; Cyclin B1 / metabolism; Cytochromes c / metabolism; Diet; HeLa Cells; Humans; Hydrogen-Ion Concentration; Hydrolyzable Tannins / pharmacology; Juglans / chemistry; MCF-7 Cells; Mice; Mice, Nude; Mitochondria / drug effects; Nuts / chemistry; Plant Extracts / pharmacology
TL;DR:
The results suggest impairment of mitochondrial function and apoptosis as relevant mechanism of anticancer effects of the walnut extract as well as antimitogenic effects of walnuts.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2014 journal article
Phlorotannins from Alaskan Seaweed Inhibit Carbolytic Enzyme Activity
MARINE DRUGS, 12(10), 5277–5294.
Contributors: J. Kellogg n, M. Grace n & M. Lila n
author keywords: Alaska; seaweed; diabetes; glucosidase; hyperglycemia; amylase; type 2 diabetes mellitus; phlorotannin; polyphenol; ethnopharmacology
MeSH headings : Animals; Biological Factors / metabolism; Biological Factors / pharmacology; Carbohydrates; Enzyme Inhibitors / metabolism; Enzyme Inhibitors / pharmacology; Fucus / metabolism; Kinetics; Saccharomyces cerevisiae / metabolism; Seaweed / metabolism; Swine / metabolism; Tannins / metabolism; Tannins / pharmacology; alpha-Amylases / antagonists & inhibitors; alpha-Glucosidases / metabolism
TL;DR:
It is suggested that coastal Alaskan seaweeds are sources of α-glucosidase and α-amylase inhibitory phlorotannins, and thus have potential to limit the release of sugar from carbohydrates and thus alleviate postprandial hyperglycemia.
(via Semantic Scholar)
www.mdpi.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2014 journal article
Ligularia fischeri Extract Protects Against Oxidative-Stress-Induced Neurotoxicity in Mice and PC12 Cells
JOURNAL OF MEDICINAL FOOD, 17(11), 1222–1231.
author keywords: Ligularia fischeri; amyloid beta peptide; 3-O-caffeoylquinic acid; oxidative stress
MeSH headings : Alzheimer Disease / metabolism; Alzheimer Disease / prevention & control; Amyloid beta-Peptides / metabolism; Amyloid beta-Peptides / toxicity; Animals; Antioxidants / pharmacology; Antioxidants / therapeutic use; Asteraceae / chemistry; Avoidance Learning / drug effects; Brain / drug effects; Chlorogenic Acid / pharmacology; Chlorogenic Acid / therapeutic use; Cognition Disorders / chemically induced; Cognition Disorders / genetics; Cognition Disorders / prevention & control; DNA Fragmentation / drug effects; Hydrogen Peroxide / metabolism; Hydrogen Peroxide / toxicity; Learning Disabilities / chemically induced; Learning Disabilities / prevention & control; Lipid Peroxidation / drug effects; Male; Memory / drug effects; Memory Disorders / chemically induced; Memory Disorders / prevention & control; Mice, Inbred ICR; Neuroprotective Agents / pharmacology; Neuroprotective Agents / therapeutic use; Neurotoxicity Syndromes / genetics; Neurotoxicity Syndromes / prevention & control; Oxidative Stress / drug effects; PC12 Cells; Phytotherapy; Plant Extracts / pharmacology; Plant Extracts / therapeutic use; Rats
TL;DR:
Results suggest that L. fischeri extract could be protective against Aβ-induced neurotoxicity, possibly due to the antioxidative capacity of its constituent, 3-O-caffeoylquinic acid.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 conference paper
Capitalizing on the health benefits of berryfruit: Science versus the marketplace
Ii international symposium on biotechnology of fruit species, 1048, 123–128.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: NC State University Libraries, ORCID
Added: August 6, 2018
2014 journal article
Simultaneous saccharification and fermentation of industrial sweetpotatoes for ethanol production and anthocyanins extraction
INDUSTRIAL CROPS AND PRODUCTS, 62, 53–60.
author keywords: Ipomoea batatas; Kluyveromyces marxianus; Saccharomyces cerevisiae; Antioxidants; Fermentation; Starch; Sweet potato
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(Web of Science)
12. Responsible Consumption and Production
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2014 journal article
Efficient preparative isolation and identification of walnut bioactive components using high-speed counter-current chromatography and LC-ESI-IT-TOF-MS
FOOD CHEMISTRY, 158, 229–238.
Contributors: M. Grace n , C. Warlick n, S. Neff n & M. Lila n
author keywords: Walnut; Jug Ions regia; Ellagitannins; High-speed counter-current; chromatography; ESI-MS/MS
MeSH headings : Chromatography, High Pressure Liquid / methods; Countercurrent Distribution / methods; Juglans / chemistry; Tandem Mass Spectrometry / methods
TL;DR:
These results provided a foundation for in depth characterisation of walnut compounds and offered an efficient strategy for isolation of potentially health-relevant phytochemicals from walnuts.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2014 journal article
Comparative Analysis of Phenolic Content and Profile, Antioxidant Capacity, and Anti-inflammatory Bioactivity in Wild Alaskan and Commercial Vaccinium Berries
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 62(18), 4007–4017.
Contributors: M. Grace n , D. Esposito n , K. Dunlap* & M. Lila n
author keywords: Vaccinium vitis-idaea; V. uliginosum; V. macrocarpon; V. angustifolium; phenolics; antioxidant; anti-inflammatory
MeSH headings : Alaska; Animals; Anti-Inflammatory Agents / chemistry; Anti-Inflammatory Agents / pharmacology; Antioxidants / chemistry; Antioxidants / pharmacology; Chromatography, High Pressure Liquid; Fruit / chemistry; Macrophages / drug effects; Macrophages / immunology; Mass Spectrometry; Mice; Phenols / chemistry; Plant Extracts / chemistry; Plant Extracts / pharmacology; Vaccinium / chemistry
TL;DR:
A polyphenol-rich fraction from lowbush cranberry exhibited dose-dependent inhibition of LPS-elicited induction of IL-1β in RAW 2647 cells, indicative of strong anti-inflammatory activity, corroborate the historic use of wild Alaskan berries as medicinally important foods in Alaska Native communities.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2014 journal article
Anthocyanin profiling of wild maqui berries (Aristotelia chilensis [Mol.] Stuntz) from different geographical regions in Chile
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 94(13), 2639–2648.
Contributors: C. Fredes *, G. Yousef n, P. Robert *, M. Grace n , M. Lila n , M. Gómez*, M. Gebauer*, G. Montenegro*
author keywords: delphinidin-3; 5-diglucoside; delphinidin-3-glucoside; genetic diversity; maqui genotypes; ISSR-PCR
MeSH headings : Altitude; Anthocyanins / analysis; Anthocyanins / metabolism; Antioxidants / analysis; Antioxidants / metabolism; Chile; Chromatography, High Pressure Liquid; Climate; Elaeocarpaceae / chemistry; Elaeocarpaceae / genetics; Elaeocarpaceae / growth & development; Elaeocarpaceae / metabolism; Fruit / chemistry; Fruit / genetics; Fruit / growth & development; Fruit / metabolism; Genetic Markers; Genetic Variation; Limit of Detection; Phenols / analysis; Phenols / metabolism; Phylogeny; Spatio-Temporal Analysis; Species Specificity; Spectrometry, Mass, Electrospray Ionization; Wilderness
TL;DR:
Three maqui genotypes exhibited significantly higher anthocyanin content than the others, as measured by pH differential method and high-performance liquid chromatography-mass spectrometry and significant genetic diversity was noted within each ecological population.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2014 journal article
Activation of pattern recognition receptors in brown adipocytes induces inflammation and suppresses uncoupling protein 1 expression and mitochondrial respiration
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 306(10), C918–C930.
author keywords: brown adipose tissue; brown adipocytes; UCP-1; pattern recognition receptor; inflammation
MeSH headings : Adipocytes / drug effects; Adipocytes / metabolism; Adipocytes / pathology; Adipose Tissue, Brown / drug effects; Adipose Tissue, Brown / metabolism; Adipose Tissue, Brown / pathology; Animals; Cell Line; Cytokines / genetics; Cytokines / metabolism; Diet, High-Fat; Electron Transport / drug effects; Gene Expression Regulation; Inflammation / genetics; Inflammation / metabolism; Inflammation / pathology; Ion Channels / genetics; Ion Channels / metabolism; Isoproterenol / pharmacology; Male; Mice; Mitochondria / drug effects; Mitochondria / metabolism; Mitochondrial Proteins / genetics; Mitochondrial Proteins / metabolism; Mitogen-Activated Protein Kinases / genetics; Mitogen-Activated Protein Kinases / metabolism; NF-kappa B / genetics; NF-kappa B / metabolism; Nod1 Signaling Adaptor Protein / genetics; Nod1 Signaling Adaptor Protein / metabolism; Nod2 Signaling Adaptor Protein / genetics; Nod2 Signaling Adaptor Protein / metabolism; Obesity / genetics; Obesity / metabolism; Obesity / pathology; Promoter Regions, Genetic; RNA, Messenger / genetics; RNA, Messenger / metabolism; Signal Transduction; Toll-Like Receptor 2 / genetics; Toll-Like Receptor 2 / metabolism; Toll-Like Receptor 4 / genetics; Toll-Like Receptor 4 / metabolism; Uncoupling Protein 1
TL;DR:
The role of selected PRR activation in inducing inflammation and downregulation of UCP-1 expression and mitochondrial respiration in brown adipocytes is demonstrated and novel targets in BAT are uncovered for obesity treatment and prevention.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2014 article
Stressed for Success: How the Berry's Wild Origins Result in Multifaceted Health Protections
X INTERNATIONAL SYMPOSIUM ON VACCINIUM AND OTHER SUPERFRUITS, Vol. 1017, pp. 23–43.
author keywords: elicitation; anthocyanins; proanthocyanidins; inflammation; metabolic syndrome
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2014 journal article
Quinoa seeds leach phytoecdysteroids and other compounds with anti-diabetic properties
FOOD CHEMISTRY, 163, 178–185.
Contributors: B. Graf*, A. Poulev*, P. Kuhn *, M. Grace n , M. Lila n & I. Raskin *
author keywords: Ecdysterone; Flavonoids; Metabolic syndrome; Nutraceutical; Phytoecdysteroids
MeSH headings : Animals; Chenopodium quinoa / chemistry; Chromatography, Liquid; Ecdysterone / isolation & purification; Ecdysterone / pharmacology; Hypoglycemic Agents / isolation & purification; Male; Mice; Mice, Inbred C57BL; Seeds / chemistry
TL;DR:
Leaching effectively releases and concentrates bioactive phytochemicals from quinoa seeds, providing an efficient means to produce a food-grade mixture that may be useful for anti-diabetic applications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2014 journal article
Orthosiphol A from the aerial parts of Orthosiphon aristatus is putatively responsible for hypoglycemic effect via α-glucosidase inhibition
Natural Product Communications, 9(5), 639–641. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901606984&partnerID=MN8TOARS
Contributors: T. Damsud, M. Grace , S. Adisakwattana & P. Phuwapraisirisan
Sources: NC State University Libraries, ORCID
Added: August 6, 2018
2014 journal article
Impact of interspecific introgression on anthocyanin profiles of Southern Highbush blueberry
Journal of the American Society for Horticultural Science, 139(2), 99–112.
Source: NC State University Libraries
Added: August 6, 2018
2014 journal article
Development of NIRS models to predict composition of enzymatically processed sweetpotato
INDUSTRIAL CROPS AND PRODUCTS, 59, 119–124.
author keywords: Near-infrared spectroscopy (NIRS); Ipomoea batatas; Hydrolysis; Starch; Protein; Fiber
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2014 journal article
Stable, water extractable isothiocyanates from Moringa oleifera leaves attenuate inflammation in vitro
PHYTOCHEMISTRY, 103, 114–122.
author keywords: Moringa oleifera; Moringaceae Chronic inflammation; Isothiocyanates; 4-[(alpha-L-rhamnosyloxy) benzyl]isothiocyanate; 4-[(4'-O-acetyl-alpha-L-rhamnosyloxy) benzyl]isothiocyanate
MeSH headings : Animals; Anti-Inflammatory Agents / chemistry; Anti-Inflammatory Agents / pharmacology; Cell Line; Interleukin-1beta / metabolism; Isothiocyanates / chemistry; Isothiocyanates / pharmacology; Macrophages / drug effects; Macrophages / metabolism; Mice; Moringa oleifera; Nitric Oxide / metabolism; Nitric Oxide Synthase Type II / metabolism; Plant Extracts / chemistry; Plant Extracts / pharmacology; Plant Leaves / chemistry; Water / chemistry
TL;DR:
A potential for stable and concentrated moringa isothiocyanates, delivered in MC as a food-grade product, to alleviate low-grade inflammation associated with chronic diseases is suggested.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2014 journal article
Selection and characterization of DNA aptamers specific for Listeria species
ANALYTICAL BIOCHEMISTRY, 459, 39–45.
author keywords: Listeria monocytogenes; Listeria spp.; Aptamer; SELEX; Pathogen detection
MeSH headings : Aptamers, Nucleotide / chemistry; Aptamers, Nucleotide / genetics; Aptamers, Nucleotide / metabolism; Base Sequence; Binding Sites; Cell Survival; Listeria monocytogenes / cytology; Listeria monocytogenes / metabolism; SELEX Aptamer Technique / methods; Species Specificity; Substrate Specificity
TL;DR:
This is the first study in which SELEX targeted bacterial cells at different growth phases and found that aptamers that bind to different cell surface moieties could increase the analytical sensitivity of future capture and detection assays.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Neuroprotective effects of anthocyanin- and proanthocyanidin-rich extracts in cellular models of Parkinson׳s disease
Brain Research, 1555, 60–77.
Contributors: K. Strathearn*, G. Yousef n, M. Grace n , S. Roy*, M. Tambe *, M. Ferruzzi*, Q. Wu *, J. Simon *, M. Lila n , J. Rochet *
author keywords: Anthocyanin; Microglial activation; Mitochondria; Parkinson's disease; Proanthocyanidin; Rotenone
MeSH headings : Animals; Anthocyanins / therapeutic use; Cells, Cultured; Dopaminergic Neurons / drug effects; Dopaminergic Neurons / metabolism; Mice; Microglia / drug effects; Mitochondria / drug effects; Mitochondria / metabolism; Neuroprotective Agents / therapeutic use; Parkinson Disease / drug therapy; Parkinson Disease / metabolism; Phytotherapy; Plant Extracts / therapeutic use; Proanthocyanidins / therapeutic use; Rotenone / toxicity; Tyrosine 3-Monooxygenase / metabolism
TL;DR:
It is suggested that anthocyanin- and proanthocyanidin-rich botanical extracts may alleviate neurodegeneration in PD via enhancement of mitochondrial function.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2014 journal article
Leishmanicidal activity of a daucane sesquiterpene isolated from Eryngium foetidum
PHARMACEUTICAL BIOLOGY, 52(3), 398–401.
Contributors: P. Rojas-Silva *, R. Graziose*, B. Vesely *, A. Poulev*, F. Mbeunkui n, M. Grace n , D. Kyle *, M. Lila n , I. Raskin *
author keywords: Apiaceae; bioassay guided fractionation; cytotoxicity; leishmaniasis; LC-MS; NMR; sesquiterpenoids
MeSH headings : Animals; Antiprotozoal Agents / administration & dosage; Antiprotozoal Agents / isolation & purification; Antiprotozoal Agents / pharmacology; Cell Line; Chromatography / methods; Chromatography, High Pressure Liquid / methods; Eryngium / chemistry; Inhibitory Concentration 50; Leishmania / drug effects; Leishmania donovani / drug effects; Magnetic Resonance Spectroscopy / methods; Mass Spectrometry / methods; Myoblasts / drug effects; Myoblasts / metabolism; Myoblasts, Skeletal / drug effects; Myoblasts, Skeletal / metabolism; Plant Components, Aerial; Rats; Sesquiterpenes / administration & dosage; Sesquiterpenes / isolation & purification; Sesquiterpenes / pharmacology; Toxicity Tests
TL;DR:
The bioassay-guided fractionation with the leishmanicidal and cytotoxicity activities of two compounds isolated for the first time from an Eryngium species were presented.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2014 journal article
Effects of a high fat meal matrix and protein complexation on the bioaccessibility of blueberry anthocyanins using the TNO gastrointestinal model (TIM-1)
FOOD CHEMISTRY, 142, 349–357.
Contributors: D. Ribnicky*, D. Roopchand *, A. Oren*, M. Grace n , A. Poulev*, M. Lila n , R. Havenaar, I. Raskin *
author keywords: Blueberry; Anthocyanins; Bioavailability; Bioaccessibility; Gastrointestinal model; TIM-1; Soybean flour; Nutrition
MeSH headings : Anthocyanins / metabolism; Anthocyanins / pharmacokinetics; Biological Availability; Blueberry Plants / metabolism; Cell Line; Dietary Fats / analysis; Dietary Fats / metabolism; Digestion; Fruit / metabolism; Gastrointestinal Tract / metabolism; Humans; Intestinal Absorption; Models, Biological; Soybean Proteins / chemistry; Soybean Proteins / metabolism
TL;DR:
The TNO intestinal model (TIM-1) of the human upper gastrointestinal tract was used to compare intestinal absorption/bioaccessibility of blueberry anthocyanins under different digestive conditions, suggesting lipid-rich matrices selectively effect Anthocyanin bioaccessibility.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2014 journal article
Phytochemical changes in phenolics, anthocyanins, ascorbic acid, and carotenoids associated with sweetpotato storage and impacts on bioactive properties
FOOD CHEMISTRY, 145, 717–724.
Contributors: M. Grace n , G. Yousef n, S. Gustafson n, V. Truong, G. Yencho n & M. Lila n
author keywords: Sweetpotato; Phenolics; Carotenoids; Antioxidant activity; Storage; Postharvest
MeSH headings : Anthocyanins / analysis; Anthocyanins / isolation & purification; Anti-Inflammatory Agents / chemistry; Anti-Inflammatory Agents / isolation & purification; Antioxidants / chemistry; Antioxidants / isolation & purification; Ascorbic Acid / analysis; Ascorbic Acid / isolation & purification; Carotenoids / analysis; Carotenoids / isolation & purification; Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid; Food Storage; Genotype; Humans; Ipomoea batatas / chemistry; Ipomoea batatas / genetics; Ipomoea batatas / metabolism; Lipopolysaccharides; Phenols / analysis; Phenols / isolation & purification; Plant Extracts / chemistry; Reactive Oxygen Species / metabolism; Temperature; Time Factors
TL;DR:
Gradual changes in sweetpotato phytochemical content and antioxidant and anti-inflammatory capacity were noted during normal long-term storage, but the specific effects were genotype-dependent.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
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