Works Published in 2012
Displaying works 21 - 40 of 111 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2012 journal article
Dietary Flavonoids and Risk of Stroke in Women
Stroke, 43(4), 946–951.
author keywords: citrus fruits; flavanones; flavonoids; hemorrhagic; ischemic; polyphenols; stroke
MeSH headings : Adult; Brain Ischemia / epidemiology; Brain Ischemia / prevention & control; Citrus; Dietary Supplements; Female; Flavonoids / administration & dosage; Follow-Up Studies; Fruit; Humans; Incidence; Intracranial Hemorrhages / epidemiology; Intracranial Hemorrhages / prevention & control; Middle Aged; Retrospective Studies; Stroke / epidemiology; Stroke / prevention & control; Surveys and Questionnaires; United States; United States Department of Agriculture
TL;DR:
Citrus fruit consumption may be associated with a reduction in stroke risk, and experimental data support these epidemiological associations that the flavanone content of citrus fruits may potentially be cardioprotective.
(via Semantic Scholar)
www.ahajournals.org (publisher PDF)
Source: Crossref
Added: January 5, 2020
2012 journal article
Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria
Proceedings of the National Academy of Sciences, 109(39), E2579–E2586.
author keywords: nuclease; site-directed mutagenesis; RNA interference; DNA interference
MeSH headings : Bacterial Proteins / genetics; Bacterial Proteins / metabolism; DNA Breaks, Double-Stranded; DNA Breaks, Single-Stranded; Endonucleases / genetics; Endonucleases / metabolism; RNA, Bacterial / genetics; RNA, Bacterial / metabolism; Ribonucleoproteins / genetics; Ribonucleoproteins / metabolism; Streptococcus thermophilus / enzymology; Streptococcus thermophilus / genetics
TL;DR:
It is demonstrated that the Cas9–crRNA complex of the Streptococcus thermophilus CRISPR3/Cas system introduces in vitro a double-strand break at a specific site in DNA containing a sequence complementary to crRNA, paving the way for engineering of universal programmable RNA-guided DNA endonucleases.
(via Semantic Scholar)
Source: ORCID
Added: January 2, 2020
2012 journal article
Analysis of the Lactobacillus casei supragenome and its influence in species evolution and lifestyle adaptation
BMC Genomics, 13(1), 533.
author keywords: Lactobacillus casei; Lactic acid bacteria; Comparative genomics; Pan-genome; Supragenome; Evolution; Adaptation
MeSH headings : Adaptation, Physiological / genetics; Biological Evolution; Cluster Analysis; Gene Transfer, Horizontal; Genome, Bacterial; Genomic Islands; Lacticaseibacillus casei / genetics; Phylogeny
TL;DR:
This study gives the first evidence for a L. casei supragenome and provides valuable insights into mechanisms for genome evolution and lifestyle adaptation of this ecologically flexible and industrially important lactic acid bacterium.
(via Semantic Scholar)
Source: ORCID
Added: January 2, 2020
2012 journal article
Persisting Viral Sequences Shape Microbial CRISPR-based Immunity
PLoS Computational Biology, 8(4), e1002475.
Ed(s): C. Mering
MeSH headings : Computer Simulation; Genetics, Population; Immunogenetic Phenomena / physiology; Inverted Repeat Sequences / physiology; Models, Genetic; Models, Immunological; Virus Physiological Phenomena
TL;DR:
A population genetic mathematical model of CRISPR-virus coevolution with six years of metagenomic sequencing is combined to link the recoverable genomic dynamics ofCRISPR loci to the unknown population dynamics of virus and host in natural communities.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Source: ORCID
Added: January 2, 2020
2012 journal article
CRISPR: New Horizons in Phage Resistance and Strain Identification
Annual Review of Food Science and Technology, 3(1), 143–162.
author keywords: bacteriophage; cas gene; interference; typing; immunity; starter culture
MeSH headings : Bacteriophages / classification; Bacteriophages / genetics; Bacteriophages / physiology; Fermentation; Food Microbiology / trends; Genes, Viral; Gram-Positive Bacteria / classification; Gram-Positive Bacteria / genetics; Gram-Positive Bacteria / metabolism; Gram-Positive Bacteria / virology; Inverted Repeat Sequences; Lysogeny; RNA Interference; RNA, Small Interfering
TL;DR:
Hypervariable CRISPR loci provide insights into the phage and host population dynamics, and new avenues for enhanced phage resistance and genetic typing and tagging of industrial strains.
(via Semantic Scholar)
Source: ORCID
Added: January 2, 2020
2012 journal article
Phage-Induced Expression of CRISPR-Associated Proteins Is Revealed by Shotgun Proteomics in Streptococcus thermophilus
PLoS ONE, 7(5), e38077.
Ed(s): H. Bruggemann
MeSH headings : Bacterial Proteins / genetics; Bacteriophages / physiology; Genetic Loci / genetics; Inverted Repeat Sequences / genetics; Proteomics; Streptococcus thermophilus / cytology; Streptococcus thermophilus / genetics; Streptococcus thermophilus / virology; Time Factors; Transcriptome / genetics
TL;DR:
Host and viral proteins were simultaneously measured following inoculation at two different multiplicities of infection and across various time points using two-dimensional liquid chromatography tandem mass spectrometry, providing novel insights into the proteomic response of S. thermophilus, specifically CRISPR-associated proteins, upon phage 2972 infection.
(via Semantic Scholar)
Source: ORCID
Added: January 2, 2020
2012 journal article
Complete Genome Sequences of Probiotic Strains Bifidobacterium animalis subsp. lactis B420 and Bi-07
Journal of Bacteriology, 194(15), 4131–4132.
MeSH headings : Bifidobacterium / genetics; Bifidobacterium / isolation & purification; DNA, Bacterial / chemistry; DNA, Bacterial / genetics; Genome, Bacterial; INDEL Mutation; Molecular Sequence Data; Polymorphism, Single Nucleotide; Probiotics; Repetitive Sequences, Nucleic Acid; Sequence Analysis, DNA
TL;DR:
Comparative genomic analysis with the type strain DSMZ10140 revealed 40 to 55 single nucleotide polymorphisms and an indel in a clustered regularly interspaced short palindromic repeat (CRISPR) locus that provide a molecular basis for strain typing within the two main phylogenetic groups of this monomorphic species.
(via Semantic Scholar)
Source: ORCID
Added: January 2, 2020
2012 article
Applications of the Versatile CRISPR-Cas Systems
CRISPR-Cas Systems, pp. 267–286.
TL;DR:
The ability to readily transfer functional CRISPR-Cas systems across even distant bacteria, and re-program their endonuclease activity make them amenable to genetic engineering and useful for genome editing.
(via Semantic Scholar)
Source: ORCID
Added: January 2, 2020
2012 article
Applications of the Versatile CRISPR-Cas Systems
CRISPR-Cas Systems, pp. 267–286.
Source: ORCID
Added: January 2, 2020
2012 journal article
RNA-mediated programmable DNA cleavage
Nature Biotechnology, 30(9), 836–838.
MeSH headings : Bacteriophages / immunology; DNA Breaks, Double-Stranded; DNA Cleavage; Deoxyribonucleases, Type II Site-Specific / metabolism; Inverted Repeat Sequences; RNA / metabolism; Streptococcus pyogenes / enzymology
TL;DR:
Genome engineering has a new tool—endonucleases involved in bacterial adaptive immunity that can be reprogrammed with customizable small, noncoding RNAs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: ORCID
Added: January 2, 2020
2012 journal article
Phage mutations in response to CRISPR diversification in a bacterial population
Environmental Microbiology, 15(2), 463–470.
MeSH headings : Bacteriophages / genetics; Bacteriophages / physiology; Base Sequence; Biological Evolution; DNA, Intergenic / genetics; Genetic Variation; Genome, Viral / genetics; Humans; Molecular Sequence Data; Mutation; Polymorphism, Single Nucleotide; Streptococcus thermophilus / genetics; Streptococcus thermophilus / virology
TL;DR:
The sequential fixation or near fixation of these single mutations indicates selection events so severe that single phage genotypes ultimately gave rise to all surviving lineages and potentially carried traits unrelated to immunity to fixation, suggesting a strong selective advantage for the phage that mutated in this region.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Source: ORCID
Added: January 2, 2020
2012 journal article
The impact of human metabolism on the bioactivity of anthocyanins
Proceedings of the Nutrition Society, 71(OCE2).
TL;DR:
This work explored the bioactivity ofthese metabolites on vascular health by measuring the effects on mediators of nitric oxide bioavailability including endothelial nitric oxidesynthase (eNOS), NADPH oxidase (NOX4) and superoxide.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: November 13, 2019
2012 journal article
Relative impact of flavonoid composition, dose and structure on vascular function: a systematic review of randomised controlled trials of flavonoid-rich food products
Molecular Nutrition & Food Research, 56(11), 1605–1616.
Source: ORCID
Added: November 13, 2019
2012 journal article
Investigating the bioavailability of anthocyanin metabolites
Proceedings of the Nutrition Society, 71(OCE2).
TL;DR:
Clinical samples from a 12-week anthocyanin intervention where 52 postmenopausal females were fed 500 mg/day elderberry extract were analysed and nine metabolites were identified, including nine currently unidentified metabolites which are the focus of future investigation.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: November 13, 2019
2012 journal article
Higher anthocyanin intake is associated with lower arterial stiffness and central blood pressure in women--
The American Journal of Clinical Nutrition, 96(4), 781–788.
Source: ORCID
Added: November 13, 2019
2012 journal article
Diets Containing Pistachios Reduce Systolic Blood Pressure and Peripheral Vascular Responses to Stress in Adults With Dyslipidemia
Hypertension, 60(1), 58–63.
author keywords: diet; stress; blood pressure; endothelium; total peripheral resistance; nuts; pistachios
MeSH headings : Adult; Blood Pressure / physiology; Brachial Artery / diagnostic imaging; Brachial Artery / physiopathology; Cardiac Output / physiology; Cross-Over Studies; Diet, Fat-Restricted / methods; Dose-Response Relationship, Drug; Dyslipidemias / physiopathology; Fasting; Heart Rate / physiology; Humans; Outcome Assessment, Health Care; Pistacia; Stress, Physiological / physiology; Ultrasonography; Vascular Resistance / physiology
TL;DR:
Reductions in peripheral vascular constriction and the resulting decrease in hemodynamic load may be important contributors to lower risk in nut consumers.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: November 13, 2019
2012 journal article
Effect of cyanidin-glucoside and its metabolites on inflammatory biomarkers of vascular function
Proceedings of the Nutrition Society, 71(OCE2).
TL;DR:
The ability of cyanidin-glucoside (C3G), the most abundant dietary anthocyanin, and its metabolites to modulate the expression of CAMs and cytokines in cultured human umbilical vein endothelial cells (HUVECs) challenged with either CD40L or oxLDL is investigated.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: November 13, 2019
2012 journal article
Effects of chocolate, cocoa, and flavan-3-ols on cardiovascular health: a systematic review and meta-analysis of randomized trials--
The American Journal of Clinical Nutrition, 95(3), 740–751.
Source: ORCID
Added: November 13, 2019
2012 journal article
Dietary flavonoids and risk of stroke in women
Stroke, STROKEAHA-111.
Source: ORCID
Added: November 13, 2019
2012 journal article
Marination with natural curing ingredients, storage time, and serving temperature effects on the sensory characteristics of forage-finished or commercially-sourced beef roasts
MEAT SCIENCE, 90(3), 747–754.
author keywords: Beef; Cured; Forage-fed; Marination; Natural; Sensory
MeSH headings : Animals; Cattle; Color; Cooking / methods; Flavoring Agents / metabolism; Food Storage / methods; Hot Temperature; Lipid Metabolism; Meat Products; Muscle, Skeletal / chemistry; Salts; Taste; Time Factors
TL;DR:
Marinating forage-finished beef roasts significantly improves tenderness and flavor characteristics and curing roasts improved TBARS values in roasts served hot and significantly reduced sensory warmed-over and grassy flavors.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.
Certain data included herein are derived from the Web of Science© and InCites© (2024) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.
