Center for Urban Affairs and Community Services

Works Published in 2003

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Displaying all 6 works

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2003 article

Human neutrophil elastase provokes release of MUC5B mucin from normal bronchial epithelial cells in vitro via a PKC-dependent mechanism.

American Journal of Respiratory and Critical Care Medicine, Vol. 167, p. A203.

By: J. Park, F. He, Y. Li, L. Martin & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2003 article

Differential effects of albuterol isomers on normal human bronchial epithelial cells in vitro.

American Journal of Respiratory and Critical Care Medicine, Vol. 167, p. A205.

Source: NC State University Libraries
Added: August 6, 2018

2003 article

A myristoylated peptide directed against the N-terminal region of MARCKS protein inhibits mucin secretion in ovalbumin sensitized/challenged mice in vivo.

American Journal of Respiratory and Critical Care Medicine, Vol. 167, p. A17.

By: B. Vargaftig, M. Singer, L. Martin, Y. Li & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2003 journal article

Effects of TNF alpha on expression of ICAM-1 in human airway epithelial cells in vitro: Oxidant-mediated pathways and transcription factors

FREE RADICAL BIOLOGY AND MEDICINE, 35(9), 1158–1167.

By: T. Krunkosky n, L. Martin n, B. Fischer n, J. Voynow* & K. Adler n

author keywords: intercellular adhesion molecule 1; normal human bronchial epithelial cells; nuclear factor kappa beta; CAAT/enhancer binding protein; free radicals
MeSH headings : Antioxidants / pharmacology; Antioxidants / toxicity; Bronchi / cytology; CCAAT-Enhancer-Binding Proteins / metabolism; Cell Line; Consensus Sequence / genetics; Cysteine Endopeptidases / metabolism; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Gene Expression Regulation / drug effects; Humans; Intercellular Adhesion Molecule-1 / genetics; Leupeptins / pharmacology; Multienzyme Complexes / antagonists & inhibitors; Multienzyme Complexes / metabolism; NF-kappa B / metabolism; Oxidants / metabolism; Promoter Regions, Genetic / genetics; Proteasome Endopeptidase Complex; Pyrrolidines / pharmacology; Pyrrolidines / toxicity; RNA, Messenger / genetics; RNA, Messenger / metabolism; Reactive Oxygen Species / metabolism; Response Elements / genetics; Signal Transduction / drug effects; Thiocarbamates / pharmacology; Thiocarbamates / toxicity; Thiourea / analogs & derivatives; Thiourea / pharmacology; Thiourea / toxicity; Transcription Factors / metabolism; Tumor Necrosis Factor-alpha / pharmacology
TL;DR: Results suggest that although TNFα enhances binding of C/EBP and NFκB complexes in NHBE cells, C-EBP binding seems to involve an oxidant-dependent mechanism, whereas activation of NFκBs complexes utilizes the ubiquitin-proteasome pathway, a mechanism that seems to be unaltered by the presence of antioxidants. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2003 article

Proliferation of the airway epithelium in asthma - Are inflammatory cells required?

Booth, B. W., Newcomb, D. C., McKane, S. A., Crews, A. L., Adler, K. B., Bonner, J. C., & Martin, L. D. (2003, March). CHEST, Vol. 123, pp. 384S–385S.

MeSH headings : Asthma / pathology; Asthma / physiopathology; Cell Physiological Phenomena; Humans; In Vitro Techniques; Inflammation / pathology; Inflammation / physiopathology; Respiratory Mucosa / pathology; Respiratory Mucosa / physiopathology
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2003 journal article

PI3K signaling is required for prostaglandin-induced mucosal recovery in ischemia-injured porcine ileum

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 284(1), G46–G56.

author keywords: phosphatidylinositol 3-kinase; tight junction; occludin; zonula occludens-1
MeSH headings : 16,16-Dimethylprostaglandin E2 / pharmacology; Animals; Anti-Ulcer Agents / pharmacology; Electric Impedance; Epoprostenol / analogs & derivatives; Epoprostenol / pharmacology; Female; Humans; Ileum / metabolism; Intestinal Mucosa / enzymology; Intestinal Mucosa / ultrastructure; Ischemia / metabolism; Male; Membrane Proteins / metabolism; Microscopy, Electron; Occludin; Osmotic Pressure; Phosphatidylinositol 3-Kinases / metabolism; Phosphoproteins / metabolism; Platelet Aggregation Inhibitors / pharmacology; Recovery of Function / physiology; Signal Transduction / drug effects; Signal Transduction / physiology; Swine; Tight Junctions / enzymology; Urea / pharmacology; Zonula Occludens-1 Protein
TL;DR: These experiments suggest that PGs stimulate recovery of paracellular resistance via a mechanism involving transepithelial osmotic gradients and PI3K-dependent restoration of tight junction protein distribution. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

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