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Sorted by most recent date added to the index first, which may not be the same as publication date order.

2024 journal article

A statistical approach to system suitability testing for mass spectrometry imaging

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 38(9).

By: A. Sohn n, R. Kibbe n, O. Dioli n, E. Hector n , H. Bai n, K. Garrard n, D. Muddiman n 

topics (OpenAlex): Mass Spectrometry Techniques and Applications; Metabolomics and Mass Spectrometry Studies; Pesticide Residue Analysis and Safety
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UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: March 18, 2024

2023 article

Maximized Spatial Information and Minimized Acquisition Time of Top-Hat IR-MALDESI-MSI of Zebrafish Using Nested Regions of Interest (nROIs)

Joignant, A. N., Ritter, M. M., Knizner, K. T., Garrard, K. P., Kullman, S. W., & Muddiman, D. C. (2023, August 1). JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, Vol. 8.

By: A. Joignant n, M. Ritter  n, K. Knizner n, K. Garrard n, S. Kullman n  & D. Muddiman n 

author keywords: IR-MALDESI; mass spectrometry imaging; spatialresolution; nested region of interest; zebrafish
topics (OpenAlex): Mass Spectrometry Techniques and Applications; Metabolomics and Mass Spectrometry Studies; Physiological and biochemical adaptations
TL;DR: The nROI method was characterized on mouse liver and applied to top-hat MSI of zebrafish using a novel optical train, which resulted in a significant improvement in both acquisition time and spatial detail of the zebra fish. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 21, 2023

2023 article

Automatic z-Axis Correction for IR-MALDESI Mass Spectrometry Imaging of Uneven Surfaces

Xi, Y., Knizner, K. T. T., Garrard, K. P. P., & Muddiman, D. C. C. (2023, June 12). JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, Vol. 6.

By: Y. Xi n, K. Knizner n, K. Garrard n & D. Muddiman n 

author keywords: mass spectrometry imaging; nonflat surfaces; IR-MALDESI; automatic z-axis correction
topics (OpenAlex): Mass Spectrometry Techniques and Applications; Analytical Chemistry and Chromatography; Metabolomics and Mass Spectrometry Studies
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UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: June 26, 2023

2023 journal article

Quasi-continuous infrared matrix-assisted laser desorption electrospray ionization source coupled to a quadrupole time-of-flight mass spectrometer for direct analysis from well plates

JOURNAL OF MASS SPECTROMETRY, 58(1).

By: C. Arciniega n, K. Garrard n, J. Guymon n , J. Manni Sr, A. Apffel*, J. Fjeldsted*, D. Muddiman n 

author keywords: ambient ionization; direct analysis; IR-MALDESI; Q-TOF mass spectrometer
topics (OpenAlex): Mass Spectrometry Techniques and Applications; Analytical Chemistry and Chromatography; Microfluidic and Capillary Electrophoresis Applications
TL;DR: An infrared matrix‐assisted laser desorption electrospray ionization (IR‐MALDESI) source coupled directly to an Agilent 6545 for direct analysis from well plates and is a proof of concept for HTS applications using IR‐MAL DESI coupled to a different MS platform. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: February 13, 2023

2022 journal article

Developing transmission mode for infrared matrix-assisted laser desorption electrospray ionization mass spectrometry imaging

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 36(22).

By: A. Joignant n, H. Bai n, J. Guymon n , K. Garrard n, M. Pankow n & D. Muddiman n 

MeSH headings : Animals; Glycerol; Ice; Lasers; Mammals; Mice; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
topics (OpenAlex): Mass Spectrometry Techniques and Applications; Analytical Chemistry and Chromatography; Metabolomics and Mass Spectrometry Studies
TL;DR: This work has successfully demonstrated the adaptation of the NextGen IR‐MAL DESI source through the feasibility of tm‐IR‐MALDESI mass spectrometry imaging on mammalian tissue, expanding future biological applications of the method. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: September 26, 2022

2021 journal article

Vitamin D deficiency promotes accumulation of bioactive lipids and increased endocannabinoid tone in zebrafish

JOURNAL OF LIPID RESEARCH, 62.

By: M. Knuth  n, W. Stutts n , M. Ritter  n, K. Garrard n & S. Kullman n 

author keywords: MS; metabolomics; lipidomics; lipids; nutrition; endocannabinoid biosynthesis; MSI; IR-MALDESI; anandamide
MeSH headings : Animals; Endocannabinoids / metabolism; Lipid Metabolism; Lipids / chemistry; Vitamin D Deficiency / metabolism; Zebrafish
topics (OpenAlex): Adipose Tissue and Metabolism; Metabolomics and Mass Spectrometry Studies; Birth, Development, and Health
TL;DR: Investigation of putative linkages between vitamin D deficiency and metabolic disruption of bioactive lipids by MS imaging and expression of genes involved in EC biosynthesis, metabolism, and receptor signaling in adipose tissue and liver suggest that VDD may promote accumulation of bio active lipids and increased EC tone in zebrafish. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
Sources: ORCID, Web Of Science, NC State University Libraries
Added: October 19, 2021

2021 journal article

In situ detection of fatty acid C=C positional isomers by coupling on-tissue mCPBA epoxidation with infrared matrix-assisted laser desorption electrospray ionization mass spectrometry

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 35(13).

By: A. Tu n, K. Garrard n, N. Said * & D. Muddiman n 

topics (OpenAlex): Mass Spectrometry Techniques and Applications; Metabolomics and Mass Spectrometry Studies; Analytical Chemistry and Chromatography
TL;DR: The on-tissue mCPBA epoxidation was implemented into an ambient MS imaging workflow to offer a rapid and simple way for in situ identification and relative quantification of double bond positional isomers without the requirement for instrument modification. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: July 6, 2021

2021 journal article

GlycoHunter: An Open-Source Software for the Detection and Relative Quantification of INLIGHT-Labeled N-Linked Glycans

JOURNAL OF PROTEOME RESEARCH, 20(4), 1855–1863.

By: J. Kalmar n, K. Garrard n & D. Muddiman n 

author keywords: glycomics; INLIGHT; N-linked glycans; data analysis; open source; software
MeSH headings : Computational Biology; Glycomics; Polysaccharides; Software
topics (OpenAlex): Glycosylation and Glycoproteins Research; Carbohydrate Chemistry and Synthesis; Genomics and Phylogenetic Studies
TL;DR: GlycoHunter, a user-friendly software created in MATLAB that enables researchers to accurately and efficiently process MS1 glycomics data where a NAT and SIL pair is generated for relative quantification, including but not limited to, INLIGHT. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: May 3, 2021

2020 journal article

A Versatile Platform for Mass Spectrometry Imaging of Arbitrary Spatial Patterns

Journal of the American Society for Mass Spectrometry, 31(12), 2547–2552.

By: K. Garrard n, M. Ekelöf n, S. Khodjaniyazova n, M. Bagley  n & D. Muddiman n 

author keywords: Mass Spectrometry Imaging; Arbitrary Region of Interest; MALDESI; Vision-System
topics (OpenAlex): Mass Spectrometry Techniques and Applications; Analytical Chemistry and Chromatography; Spectroscopy Techniques in Biomedical and Chemical Research
TL;DR: A vision-system driven platform, RastirX, has been constructed for mass spectrometry imaging (MSI) of arbitrary two-dimensional patterns that reduces contamination from off-sample material and significantly reduces acquisition time. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: January 19, 2021

2019 journal article

Three-Dimensional Imaging with Infrared Matrix-Assisted Laser Desorption Electrospray Ionization Mass Spectrometry

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 31(2), 292–297.

By: H. Bai n, S. Khodjaniyazova n, K. Garrard n & D. Muddiman n 

author keywords: mass spectrometry imaging; 3D; IR-MALDESI; MUPS; HRAM
MeSH headings : Anti-Ulcer Agents / analysis; Citrates / analysis; Imaging, Three-Dimensional / methods; Omeprazole / analysis; Pharmaceutical Preparations / chemistry; Proton Pump Inhibitors / analysis; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Starch / analysis; Tablets, Enteric-Coated / chemistry
topics (OpenAlex): Mass Spectrometry Techniques and Applications; Analytical Chemistry and Chromatography; Ion-surface interactions and analysis
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 10, 2020

2018 journal article

Direct analysis of textile dyes from trace fibers by automated microfluidics extraction system coupled with Q-TOF mass spectrometer for forensic applications

Forensic Science International, 289, 67–74.

By: N. Sultana  n, S. Gunning n, S. Furst n, K. Garrard  n, T. Dow n & N. Vinueza  n

author keywords: Trace evidence; Textile fibers; Dyes; Microfluidics; Quadrupole-time-of-flight; Mass spectrometry
topics (OpenAlex): Cultural Heritage Materials Analysis; Isotope Analysis in Ecology; Identification and Quantification in Food
TL;DR: This study performed a direct trace fiber analysis method via dye characterization by a novel automated microfluidics device (MFD) dye extraction system coupled with a quadrupole-time-of-flight (Q-TOF) mass spectrometer (MS). (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Crossref, NC State University Libraries
Added: July 21, 2019

2018 article

Surface Finish and Diamond Tool Wear when machining PMMA and PC Optics

OPTICAL MANUFACTURING AND TESTING XII, Vol. 10742.

By: C. Bodlapati n, T. Dow n, A. Wong n & K. Garrard n

author keywords: diamond turning; polymers; surface finish; tool wear
topics (OpenAlex): Advanced Surface Polishing Techniques; Diamond and Carbon-based Materials Research; Laser Material Processing Techniques
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: December 31, 2018

2018 journal article

Evaluation of Digital Image Recognition Methods for Mass Spectrometry Imaging Data Analysis

Journal of The American Society for Mass Spectrometry, 29(12), 2467–2470.

By: M. Ekelöf n, K. Garrard n, R. Judd n, E. Rosen*, D. Xie n , A. Kashuba *, D. Muddiman n 

Contributors: M. Ekelöf n, K. Garrard n, R. Judd n, E. Rosen*, D. Xie n , A. Kashuba *, D. Muddiman n 

author keywords: Mass spectrometry imaging; Image recognition; SSIM
MeSH headings : Algorithms; Animals; Image Processing, Computer-Assisted / methods; Lymph Nodes / chemistry; Lymph Nodes / metabolism; Macaca mulatta; Maraviroc / pharmacokinetics; Mass Spectrometry / methods; Models, Theoretical; Molecular Imaging / methods; Plant Leaves / chemistry; Tissue Distribution
topics (OpenAlex): Metabolomics and Mass Spectrometry Studies; Spectroscopy and Chemometric Analyses; Advanced Chemical Sensor Technologies
TL;DR: A method for comprehensive, semi-targeted discovery of molecular distributions of interest from mass spectrometry imaging data, using widely available image similarity scoring algorithms to rank images by spatial correlation is presented. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: December 10, 2018

2017 journal article

IR-MALDESI Mass Spectrometry Imaging at 50 Micron Spatial Resolution

Journal of The American Society for Mass Spectrometry, 28(10), 2099–2107.

By: M. Bokhart n, J. Manni, K. Garrard n, M. Ekelöf n, M. Nazari n & D. Muddiman n 

author keywords: Mass spectrometry imaging; IR-MALDESI; Tissue imaging; Spatial resolution; Laser focusing
topics (OpenAlex): Mass Spectrometry Techniques and Applications; Analytical Chemistry and Chromatography; Ion-surface interactions and analysis
TL;DR: This work presents MSI using infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) at 50 μm resolution, using an adjustable iris, beam expander, and an aspherical focusing lens to reduce tissue ablation diameters for MSI at high resolution. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2017 journal article

MSiReader v1.0: Evolving Open-Source Mass Spectrometry Imaging Software for Targeted and Untargeted Analyses

Journal of The American Society for Mass Spectrometry, 29(1), 8–16.

By: M. Bokhart, M. Nazari, K. Garrard n & D. Muddiman* 

author keywords: Mass spectrometry imaging; Mass spectrometry software; Data analysis; Image processing; High mass resolving power; Open-source; Orbitrap
topics (OpenAlex): Metabolomics and Mass Spectrometry Studies; Mass Spectrometry Techniques and Applications; Isotope Analysis in Ecology
TL;DR: A major update to the mass spectrometry imaging (MSI) software MSiReader is presented, offering a multitude of newly added features critical to MSI analyses, enabling the MSI community to evaluate their data in greater depth and in less time. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2016 journal article

Design and validation of the mounting structure for BETTII balloon-based telescope with thin-walled optics

JOURNAL OF ASTRONOMICAL TELESCOPES INSTRUMENTS AND SYSTEMS, 2(2).

By: S. Furst n, T. Dow n, K. Garrard n, A. Sohn, D. Fixsen*, S. Rinehart *, E. Mentzell*, T. Veach*, M. Rizzo*, A. Dhabal *

author keywords: light-weight optics; diamond turning optics; optical mounting; kinematic coupling; Balloon Experimental Twin Telescope for Infrared Interferometry
topics (OpenAlex): Aerospace Engineering and Energy Systems; Adaptive optics and wavefront sensing; Spacecraft and Cryogenic Technologies
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Design of elliptically-vibrating ultrasonic actuator for nanocoining

PRECISION ENGINEERING-JOURNAL OF THE INTERNATIONAL SOCIETIES FOR PRECISION ENGINEERING AND NANOTECHNOLOGY, 45, 301–310.

By: T. Dow n, J. Nowak n & J. Kessing  n

author keywords: Nanocoining; Ultrasonic transducer; Nanoindentation; Structured surfaces; Diamond die; Bio-inspired technology
topics (OpenAlex): Nanofabrication and Lithography Techniques; Advanced Surface Polishing Techniques; Metal and Thin Film Mechanics
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2016 article

Optics of Balloon Experimental Twin Telescope for Infrared Interferometry (BETTII): delay lines and alignment

OPTICAL AND INFRARED INTERFEROMETRY AND IMAGING V, Vol. 9907.

By: A. Dhabal *, S. Rinehart *, M. Rizzo*, L. Mundy *, D. Fixsen*, H. Sampler*, E. Mentzell*, T. Veach* ...

co-author countries: United Kingdom of Great Britain and Northern Ireland 🇬🇧
author keywords: spatio-spectral interferometry; far infra-red; delay line; capacitive sensor; interferometric simulation; metrology; alignment
topics (OpenAlex): Adaptive optics and wavefront sensing; Astronomy and Astrophysical Research; Radio Astronomy Observations and Technology
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Silver dopants for targeted and untargeted direct analysis of unsaturated lipids via infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI)

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 28(22), 2461–2470.

By: F. Meier n, K. Garrard n & D. Muddiman n 

co-author countries: Germany 🇩🇪
MeSH headings : Alkenes / chemistry; Dried Blood Spot Testing; Fats, Unsaturated / analysis; Fats, Unsaturated / chemistry; Humans; Male; Silver / chemistry; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
topics (OpenAlex): Mass Spectrometry Techniques and Applications; Metabolomics and Mass Spectrometry Studies; Analytical Chemistry and Chromatography
TL;DR: Silver cationization has been shown to enhance IR-MALDESI sensitivity and selectivity for unsaturated lipids, even when applied to complex samples, and developed tools for peak assignment and mapping of isotopic patterns will clearly benefit future mass spectrometry imaging studies. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 journal article

MSiReader: An Open-Source Interface to View and Analyze High Resolving Power MS Imaging Files on Matlab Platform

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 24(5), 718–721.

By: G. Robichaud n, K. Garrard n, J. Barry n & D. Muddiman n 

author keywords: Mass spectrometry imaging; Software; High mass resolving power; FT-ICR-MS; Open-source
MeSH headings : Algorithms; Computational Biology; Image Processing, Computer-Assisted / methods; Internet; Mass Spectrometry / methods; Software; User-Computer Interface
topics (OpenAlex): Mass Spectrometry Techniques and Applications; Metabolomics and Mass Spectrometry Studies; Isotope Analysis in Ecology
TL;DR: MSiReader is introduced, a free open source application to read and analyze high resolution MSI data from the most common MSi data formats and is built on the Matlab platform and includes a large selection of data analysis tools and features. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
9. Industry, Innovation and Infrastructure (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 journal article

Nanostructure fabrication on germanium and silicon by nanocoining imprint technique

PRECISION ENGINEERING-JOURNAL OF THE INTERNATIONAL SOCIETIES FOR PRECISION ENGINEERING AND NANOTECHNOLOGY, 37(4), 871–879.

By: E. Zdanowicz n, T. Dow n, R. Scattergood n & K. Youssef n

author keywords: Nanocoining; Phase transformation; Nanostructured; Diamond die; Silicon; Germanium
topics (OpenAlex): Advanced Surface Polishing Techniques; Metal and Thin Film Mechanics; Force Microscopy Techniques and Applications
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Thermo-chemical wear model and worn tool shapes for single-crystal diamond tools cutting steel

WEAR, 300(1-2), 216–224.

By: B. Lane*, T. Dow n & R. Scattergood n

author keywords: Diamond tool; Electron microscopy; Diffusion; FEM
topics (OpenAlex): Advanced machining processes and optimization; Tunneling and Rock Mechanics; Advanced Surface Polishing Techniques
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Rapid fabrication of nanostructured surfaces using nanocoining

NANOTECHNOLOGY, 23(41).

By: E. Zdanowicz n, T. Dow n & R. Scattergood n

topics (OpenAlex): Advanced Surface Polishing Techniques; Nanofabrication and Lithography Techniques; Diamond and Carbon-based Materials Research
TL;DR: A new process for creating high quality ordered arrays of nanofeatures called nanocoining is presented and parameters are discussed which enable indents to be indexed precisely to completely cover target areas. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Automated Part Centering With Impulse Actuation

JOURNAL OF MANUFACTURING SCIENCE AND ENGINEERING-TRANSACTIONS OF THE ASME, 132(1).

By: S. Furst n, T. Dow n, K. Garrard n & A. Sohn n

author keywords: actuators; electric motors; hand tools; machining; plastics
topics (OpenAlex): Advanced Measurement and Metrology Techniques; Manufacturing Process and Optimization; Advanced machining processes and optimization
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Design, modeling, fabrication, and evaluation of the air amplifier for improved detection of biomolecules by electrospray ionization mass spectrometry

INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, 300(2-3), 99–107.

By: G. Robichaud n, R. Dixon n, A. Potturi n, D. Cassidy n, J. Edwards n , A. Sohn n, T. Dow n, D. Muddiman n 

author keywords: Air amplifier; Electrospray ionization; Modeling; Detection limits
topics (OpenAlex): Mass Spectrometry Techniques and Applications; Electrohydrodynamics and Fluid Dynamics; Microfluidic and Capillary Electrophoresis Applications
TL;DR: A computer simulation that accurately portrays actual conditions and the results from these simulations are corroborated by the experimental data is developed, which can be used to predict outcomes from future designs resulting in a design process that is efficient in terms of financial cost and time. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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