Works Published in 2006

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Displaying works 1 - 20 of 24 in total

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2006 journal article

EHV-1 special edition

Veterinary Immunology and Immunopathology, 111(1-2), 1.

By: D. Lunn*, J. Slater* & D. Horohov*

MeSH headings : Animals; Herpesviridae Infections / immunology; Herpesviridae Infections / prevention & control; Herpesviridae Infections / veterinary; Herpesviridae Infections / virology; Herpesvirus 1, Equid; Horse Diseases / immunology; Horse Diseases / prevention & control; Horse Diseases / virology; Horses
Source: Crossref
Added: August 28, 2020

2006 chapter

Immunology and Immunopathology

In B. McGorum, E. Robinson, P. Dixon, & J. Schumacher (Eds.), Equine Respiratory Disorders (1st ed., pp. 71–82). Philadelphia: Elsevier.

By: D. Lunn, G. Soboll & C. Breathnach

Ed(s): B. McGorum, E. Robinson, P. Dixon & J. Schumacher

Source: NC State University Libraries
Added: August 4, 2019

2006 journal article

Report of the equine herpesvirus-1 Havermeyer Workshop, San Gimignano, Tuscany, June 2004

Veterinary Immunology and Immunopathology, 111(1-2), 3–13.

By: J. Slater*, D. Lunn*, D. Horohov*, D. Antczak*, L. Babiuk*, C. Breathnach*, Y. Chang*, N. Davis-Poynter* ...

author keywords: horses; equine herpesvirus-1
MeSH headings : Animals; Herpesviridae Infections / immunology; Herpesviridae Infections / prevention & control; Herpesviridae Infections / veterinary; Herpesviridae Infections / virology; Herpesvirus 1, Equid; Horse Diseases / immunology; Horse Diseases / prevention & control; Horse Diseases / virology; Horses
TL;DR: This report highlights the new information that was the focus of a workshop convened in San Gimignano, Tuscany, Italy in June 2004, and is intended to summarize this material and identify the critical questions in the field. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: July 27, 2019

2006 journal article

Leukocyte emigration in the early stages of laminitis

Veterinary Immunology and Immunopathology, 109(1-2), 161–166.

By: S. Black*, D. Lunn*, C. Yin*, M. Hwang*, S. Lenz* & J. Belknap*

author keywords: laminitis; neutrophil; leukocyte emigration; CD13; sepsis
MeSH headings : Animals; CD13 Antigens / immunology; Cell Movement / immunology; Disease Models, Animal; Foot Diseases / immunology; Foot Diseases / veterinary; Horse Diseases / immunology; Horses; Immunohistochemistry / veterinary; Leukocyte Count / veterinary; Leukocytes, Mononuclear / immunology; Skin Diseases / immunology; Skin Diseases / veterinary
TL;DR: Findings indicate that, similar to organ failure in human sepsis, leukocyte emigration is likely to play a significant role in initiating numerous pathophysiologic mechanisms that lead to the development of laminitis. (via Semantic Scholar)
Source: Crossref
Added: July 27, 2019

2006 journal article

Cytokine responses to EHV-1 infection in immune and non-immune ponies

Veterinary Immunology and Immunopathology, 111(1-2), 109–116.

By: D. Coombs*, T. Patton*, A. Kohler*, G. Soboll*, C. Breathnach*, H. Townsend*, D. Lunn*

author keywords: horses; equine herpesvirus-1; IFN-gamma; IL-4
MeSH headings : Animals; Antibodies, Viral / blood; Cell Proliferation; DNA / chemistry; DNA / genetics; Herpesviridae Infections / genetics; Herpesviridae Infections / immunology; Herpesviridae Infections / veterinary; Herpesviridae Infections / virology; Herpesvirus 1, Equid / genetics; Herpesvirus 1, Equid / immunology; Horse Diseases / genetics; Horse Diseases / immunology; Horse Diseases / virology; Horses; Interferon-gamma / biosynthesis; Interferon-gamma / genetics; Interferon-gamma / immunology; Interleukin-4 / biosynthesis; Interleukin-4 / genetics; Interleukin-4 / immunology; Leukocytes, Mononuclear / cytology; Leukocytes, Mononuclear / virology; Male; Nasal Mucosa / virology; Neutralization Tests / veterinary; Polymerase Chain Reaction / veterinary; RNA, Messenger / biosynthesis; RNA, Messenger / genetics
TL;DR: Protective immunity to EHV-1 infection was characterized by a polarized IFN-gamma dependent immunoregulatory cytokine response. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: July 27, 2019

2006 journal article

Antibody and cellular immune responses following DNA vaccination and EHV-1 infection of ponies

Veterinary Immunology and Immunopathology, 111(1-2), 81–95.

By: G. Soboll*, S. Hussey*, J. Whalley*, G. Allen*, M. Koen*, N. Santucci*, D. Fraser*, M. Macklin*, W. Swain*, D. Lunn*

author keywords: EHV-1; horses; DNA vaccination; CTL
MeSH headings : Animals; Antibodies, Viral / blood; Cell Proliferation; Female; Genes, Immediate-Early / genetics; Genes, Immediate-Early / immunology; Herpesviridae Infections / immunology; Herpesviridae Infections / prevention & control; Herpesviridae Infections / veterinary; Herpesviridae Infections / virology; Herpesvirus 1, Equid / immunology; Herpesvirus Vaccines / immunology; Herpesvirus Vaccines / therapeutic use; Horse Diseases / immunology; Horse Diseases / prevention & control; Horse Diseases / virology; Horses; Immunoglobulin Idiotypes / immunology; Male; Neutralization Tests / veterinary; T-Lymphocytes, Cytotoxic / immunology; T-Lymphocytes, Cytotoxic / virology; Vaccination / methods; Vaccination / veterinary; Vaccines, DNA / immunology; Vaccines, DNA / therapeutic use; Viral Envelope Proteins / genetics; Viral Envelope Proteins / immunology; Virus Latency / immunology
TL;DR: In summary, particle-mediated EHV-1 DNA vaccination induced limited immune responses and protection, and future vaccination strategies must focus on generating stronger CTL responses. (via Semantic Scholar)
Source: Crossref
Added: July 27, 2019

2006 journal article

Immune responses to commercial equine vaccines against equine herpesvirus-1, equine influenza virus, eastern equine encephalomyelitis, and tetanus

Veterinary Immunology and Immunopathology, 111(1-2), 67–80.

By: M. Holmes*, H. Townsend*, A. Kohler*, S. Hussey*, C. Breathnach*, C. Barnett*, R. Holland*, D. Lunn*

author keywords: horses; vaccination; infectious disease
MeSH headings : Animals; Antibodies, Viral / blood; Clostridium tetani / immunology; DNA, Viral / chemistry; DNA, Viral / genetics; Encephalitis Virus, Eastern Equine / immunology; Encephalomyelitis, Equine / immunology; Encephalomyelitis, Equine / prevention & control; Encephalomyelitis, Equine / veterinary; Encephalomyelitis, Equine / virology; Female; Herpesviridae Infections / immunology; Herpesviridae Infections / prevention & control; Herpesviridae Infections / veterinary; Herpesviridae Infections / virology; Herpesvirus 1, Equid / genetics; Herpesvirus 1, Equid / immunology; Horse Diseases / immunology; Horse Diseases / prevention & control; Horse Diseases / virology; Horses; Immunoassay / veterinary; Influenza A Virus, H3N8 Subtype / immunology; Interferon-gamma / blood; Neutralization Tests / veterinary; Orthomyxoviridae Infections / immunology; Orthomyxoviridae Infections / prevention & control; Orthomyxoviridae Infections / veterinary; Orthomyxoviridae Infections / virology; Polymerase Chain Reaction; Tetanus / immunology; Tetanus / prevention & control; Tetanus / veterinary; Tetanus / virology; Viral Vaccines / immunology; Viral Vaccines / therapeutic use
TL;DR: Overall there were wide variations in vaccine response, and the vaccines with the best responses were not produced by a single manufacturer; differences in vaccine performance may have resulted from differences in antigen load and adjuvant formulation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: July 27, 2019

2006 journal article

Immunization with recombinant modified vaccinia Ankara (rMVA) constructs encoding the HA or NP gene protects ponies from equine influenza virus challenge

Vaccine, 24(8), 1180–1190.

By: C. Breathnach*, H. Clark*, R. Clark*, C. Olsen*, H. Townsend* & D. Lunn*

author keywords: horses; influenza virus; vaccination; haemaggluttinin; nucleoprotein
MeSH headings : Animals; Antibodies, Viral / blood; Hemagglutinin Glycoproteins, Influenza Virus / genetics; Hemagglutinin Glycoproteins, Influenza Virus / immunology; Horse Diseases / prevention & control; Horses; Immunoglobulin G / blood; Influenza A Virus, H3N8 Subtype / immunology; Influenza Vaccines / immunology; Interferon-gamma / genetics; Nucleocapsid Proteins / genetics; Nucleocapsid Proteins / immunology; Orthomyxoviridae Infections / prevention & control; Orthomyxoviridae Infections / veterinary; RNA, Messenger / analysis; T-Lymphocytes, Cytotoxic / immunology; Vaccination / veterinary; Vaccines, Synthetic / immunology; Vaccinia virus / genetics; Vaccinia virus / immunology; Virus Shedding
TL;DR: It is demonstrated that vaccination of horses with rMVA alone, or as part of a prime-boost regimen, is an effective means of inducing protective immunity to influenza virus infection, and also indicates that NP-specific immune responses can contribute to protection of horses. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: July 27, 2019

2006 journal article

Detection and Quantification of Equine Herpesvirus-1 Viremia and Nasal Shedding by Real-Time Polymerase Chain Reaction

Journal of Veterinary Diagnostic Investigation, 18(4), 335–342.

By: S. Hussey*, R. Clark*, K. Lunn*, C. Breathnach*, G. Soboll*, J. Whalley*, D. Lunn*

author keywords: diagnosis; equine herpesvirus-1; real-time PCR
MeSH headings : Animals; Female; Herpesvirus 1, Equid / genetics; Herpesvirus 1, Equid / isolation & purification; Horse Diseases / diagnosis; Horse Diseases / virology; Horses / virology; Male; Polymerase Chain Reaction / methods; Polymerase Chain Reaction / veterinary; Sensitivity and Specificity; Viremia / veterinary; Viremia / virology; Virus Latency; Virus Shedding
TL;DR: It is concluded that real-time PCR is a sensitive and quantitative test for EHV-1 nasal shedding and viremia and provides a valuable tool for E hvirus-1 surveillance, diagnosis of clinical disease, and investigation of vaccine efficacy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: July 27, 2019

2006 journal article

Foals are interferon gamma-deficient at birth

Veterinary Immunology and Immunopathology, 112(3-4), 199–209.

By: C. Breathnach*, T. Sturgill-Wright*, J. Stiltner*, A. Adams*, D. Lunn* & D. Horohov*

author keywords: equine; real time PCR; BAL; IFN; cytokine; flow cytometry; neonate
MeSH headings : Age Factors; Animals; Animals, Newborn; Bronchoalveolar Lavage Fluid / cytology; Bronchoalveolar Lavage Fluid / immunology; Colostrum / immunology; Flow Cytometry / veterinary; Gene Expression Regulation; Horses / genetics; Horses / immunology; Immunity, Innate / immunology; Interferon-gamma / deficiency; Interferon-gamma / genetics; Interferon-gamma / immunology; Ionomycin / pharmacology; Leukocytes, Mononuclear / drug effects; Leukocytes, Mononuclear / immunology; Lymphocyte Activation; Lymphocytes / immunology; RNA, Messenger / biosynthesis; RNA, Messenger / genetics; Random Allocation; Reverse Transcriptase Polymerase Chain Reaction / veterinary; Tetradecanoylphorbol Acetate / pharmacology
TL;DR: It is suggested that foals are born with an inherent inability to mount a Th1-based cell mediated immune response which may contribute to their susceptibility to intracellular pathogens. (via Semantic Scholar)
Source: Crossref
Added: July 27, 2019

2006 journal article

Epidermal growth factor receptor expression in feline oral squamous cell carcinomas

VETERINARY AND COMPARATIVE ONCOLOGY, 4(1), 33–40.

By: J. Looper n, D. Malarkey*, D. Ruslander n, D. Proulx n & D. Thrall n

author keywords: epidermal growth factor receptor; feline; immunohistochemistry; oral squamous cell carcinoma; tyrosine kinase inhibitors
TL;DR: Thirteen formalin-fixed paraffin wax-embedded biopsy samples from feline oral SCC were analysed and nine of 13 tumours were positive for EGFR expression, suggesting that altered EGFRexpression plays a role in feline Oral SCC and provides a rationale for a potential clinical benefit using EGFR inhibitors in combination with conventional treatments. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Sustained release cyclosporine therapy for bilateral keratoconjunctivitis sicca in a red wolf (Canis rufus)

JOURNAL OF ZOO AND WILDLIFE MEDICINE, 37(4), 562–564.

By: A. Acton*, A. Beale, B. Gilger* & M. Stoskopf*

author keywords: Canis rufus; cyclosporine; dry eye; keratoconjuctivitis sicca (KCS); sustained-release delivery; red wolf
MeSH headings : Animals; Cyclosporine / therapeutic use; Drug Implants / therapeutic use; Immunosuppressive Agents / therapeutic use; Keratoconjunctivitis Sicca / drug therapy; Keratoconjunctivitis Sicca / veterinary; Male; Treatment Outcome; Wolves
TL;DR: A 12-yr-old intact male red wolf diagnosed with bilateral idiopathic dry eye was treated with subconjunctival drug delivery implants designed to release therapeutic levels of cyclosporine from 12–24 mo. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Treatment of Conidiobolus sp pneumonia with itraconazole in a dog receiving immunosuppressive therapy

Journal of Veterinary Internal Medicine, 20(6), 1479–1482.

By: E. Hawkins n, A. Grooters*, E. Cowgill n, D. Proulx n, G. Davainis n, D. Ruslander n, C. Grindem n

UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Evaluation of glycosaminoglycans content and 5-hydroxytryptamine 2B receptor in the heart valves of Sprague-Dawley rats with spontaneous mitral valvulopathy - A possible exacerbation by dl-amphetamine sulfate in Fischer 344 rats?

EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, 58(2-3), 89–99.

By: C. Elangbam*, J. Wehe n, J. Barton*, D. Krull*, A. Nyska*, T. Crabbs n, G. Kissling*

author keywords: mitral valve; valvulopathy; 5-hydroxytryptamine 2B receptor; anorexigens; dl-amphetamine; quantitative image analysis; Sprague-Dawley rats; Fischer 344 rats
MeSH headings : Aging / pathology; Amphetamine / toxicity; Animals; Female; Glycosaminoglycans / analysis; Male; Mitral Valve / chemistry; Mitral Valve / drug effects; Mitral Valve / pathology; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2B / analysis
TL;DR: Examination of 5-hydroxytryptamine 2B receptor expression and characterization of extracellular matrix (ECM) components and the presence of valvulopathy in the mitral valve-leaflet of Sprague-Dawley (SD) rats suggested a role for 5HT2BR in the pathogenesis of SMV in SD rats, but additional research is needed to confirm this. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Treatment of dystocia in a leopard gecko (Eublepharis macularius) by percutaneous ovocentesis

VETERINARY RECORD, 158(21), 737-+.

By: A. Hall n & G. Lewbart n

MeSH headings : Animals; Egg Yolk; Female; Lizards / surgery; Oviposition / physiology; Suction / veterinary
TL;DR: This short communication describes the treatment of refractory dystocia in a 15-month-old female leopard gecko by percutaneous ovocentesis, a procedure apparently previously unreported in lizards. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
14. Life Below Water (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Pharmacokinetics of voriconazole after oral and intravenous administration to horses

AMERICAN JOURNAL OF VETERINARY RESEARCH, 67(6), 1070–1075.

By: J. Davis n, J. Salmon* & M. Papich*

MeSH headings : Administration, Oral; Animals; Antifungal Agents / administration & dosage; Antifungal Agents / blood; Antifungal Agents / pharmacokinetics; Biological Availability; Chemistry, Pharmaceutical; Cross-Over Studies; Drug Stability; Female; Horses / blood; Injections, Intravenous; Male; Pyrimidines / administration & dosage; Pyrimidines / blood; Pyrimidines / pharmacokinetics; Triazoles / administration & dosage; Triazoles / blood; Triazoles / pharmacokinetics; Voriconazole
TL;DR: It was concluded that administration of voriconazole at a dosage of 4 mg/kg, PO, every 24 hours will attain plasma concentrations adequate for treatment of horses with fungal infections for which the fungi have a minimum inhibitory concentration. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Percutaneous malathion absorption in the harvested perfused anuran pelvic limb

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 22(3), 263–267.

By: S. Willens n, M. Stoskopf n, R. Baynes n, G. Lewbart n, S. Taylor* & S. Kennedy-Stoskopf n

author keywords: organophosphorous; pesticide; bullfrog; Rana catesbeiana; marine toad; Bufo marinus
TL;DR: The harvested perfused anuran pelvic limb (HPAPL) model maintains the anatomic and physiologic integrity of the skin from the pelvic limb, including the intact capillary network, and is an appropriate in vitro model for examining cutaneous absorption kinetics in the bullfrog. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Percutaneous malathion absorption by anuran skin in flow-through diffusion cells

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 22(3), 255–262.

By: S. Willens n, M. Stoskopf n, R. Baynes n, G. Lewbart n, S. Taylor* & S. Kennedy-Stoskopf n

author keywords: organophosphorous; pesticide; bullfrog; Rana catesbeiana; marine toad; Bufo marinus
TL;DR: Malathion absorption was greater across the ventral skin compared to dorsal skin in both bullfrogs and marine toads and was considered a potentially important route of environmental exposure to OP compounds for amphibians, especially in aquatic environments. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Marked swelling with coalescing ecchymoses of the lower mandible in a Xenopus laevis frog

LAB ANIMAL, 35(5), 19–22.

By: C. Cannon n, K. Linder n, B. Brizuela n & S. Harvey n

MeSH headings : Animals; Ecchymosis / microbiology; Ecchymosis / pathology; Ecchymosis / veterinary; Fatal Outcome; Female; Mandible / microbiology; Mandible / pathology; Mouth Mucosa / microbiology; Mouth Mucosa / pathology; Mycobacterium Infections / complications; Mycobacterium Infections / pathology; Mycobacterium Infections / veterinary; Mycobacterium marinum / isolation & purification; Oral Ulcer / microbiology; Oral Ulcer / pathology; Oral Ulcer / veterinary; Purpura / microbiology; Purpura / pathology; Purpura / veterinary; Xenopus laevis
TL;DR: A female African clawed frog, Xenopus laevis, was housed at the Biological Resources Facility of North Carolina State University in a tank with two other females and euthanized in buffered MS-222 so that a complete necropsy could be performed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2006 article

Evaluation of factors associated with survival in dogs with untreated nasal carcinomas: 139 cases (1993-2003)

Rassnick, K. M., Goldkamp, C. E., Erb, H. N., Scrivani, P. V., Njaa, B. L., Gieger, T. L., … Kristal, O. (2006, August 1). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 229, pp. 401–406.

By: K. Rassnick, C. Goldkamp, H. Erb, P. Scrivani, B. Njaa, T. Gieger, M. Turek, E. McNiel ...

MeSH headings : Animals; Carcinoma / mortality; Carcinoma / veterinary; Confidence Intervals; Dog Diseases / mortality; Dogs; Epistaxis / mortality; Epistaxis / veterinary; Female; Male; Nose Neoplasms / mortality; Nose Neoplasms / veterinary; Odds Ratio; Prognosis; Retrospective Studies; Survival Analysis; Time Factors
TL;DR: The prognosis of dogs with untreated nasal carcinomas is poor and treatment strategies to improve outcome should be pursued. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

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