Works Published in 2019
Displaying all 17 works
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2019 journal article
Ceftiofur formulation differentially affects the intestinal drug concentration, resistance of fecal Escherichia coli, and the microbiome of steers
PLOS ONE, 14(10).
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacokinetics; Cattle; Cattle Diseases / drug therapy; Cattle Diseases / microbiology; Cephalosporins / administration & dosage; Cephalosporins / chemistry; Cephalosporins / pharmacokinetics; Drug Resistance, Bacterial; Escherichia coli / classification; Escherichia coli / drug effects; Escherichia coli / genetics; Feces / microbiology; Microbial Sensitivity Tests; Microbiota; RNA, Ribosomal, 16S / genetics
TL;DR:
CCFA leads to prolonged, low intestinal drug concentrations, and is associated with decreased E. coli concentration, an increased MIC of ceftiofur in E. Escherichia coli at specific time points, and shifts in the fecal microbiota.
(via Semantic Scholar)
journals.plos.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 1, 2020
2019 journal article
AAV-mediated expression of HLA-G1/5 reduces severity of experimental autoimmune uveitis
SCIENTIFIC REPORTS, 9.
MeSH headings : Animals; Antibodies, Neutralizing / metabolism; Dependovirus / genetics; Female; Genetic Therapy; HLA-G Antigens / genetics; HLA-G Antigens / metabolism; HLA-G Antigens / physiology; Intravitreal Injections; Rats; Uveitis / genetics; Uveitis / metabolism; Uveitis / pathology; Uveitis / therapy
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: February 10, 2020
2019 journal article
Impact of bovine respiratory disease on the pharmacokinetics of danofloxacin and tulathromycin in different ages of calves
PLOS ONE, 14(6).
Ed(s): D. Gladue
MeSH headings : Age Factors; Animals; Area Under Curve; Bronchoalveolar Lavage Fluid / chemistry; Cattle; Cattle Diseases / drug therapy; Disaccharides / administration & dosage; Disaccharides / pharmacokinetics; Extracellular Fluid / chemistry; Female; Fluoroquinolones / administration & dosage; Fluoroquinolones / pharmacokinetics; Heterocyclic Compounds / administration & dosage; Heterocyclic Compounds / pharmacokinetics; Pasteurella Infections / drug therapy; Pasteurella Infections / veterinary; Pasteurella multocida / pathogenicity; Respiration Disorders / drug therapy; Respiration Disorders / veterinary
TL;DR:
Age was determined to be a significant covariate for calves administered danofloxacin and tulathromycin for plasma PK parameters and potential reasons for age-related differences on plasma concentration–time profiles and the impact of disease on the partitioning of the drug from the blood to the lungs and ISF as a function of age are explored.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 30, 2019
2019 journal article
Consistent and correctable bias in metagenomic sequencing experiments
ELife.
MeSH headings : Bacteria / classification; Bacteria / genetics; Bias; Biota; Cluster Analysis; DNA, Ribosomal / chemistry; DNA, Ribosomal / genetics; Metagenomics / methods; Models, Theoretical; Phylogeny; RNA, Ribosomal, 16S / genetics; Sequence Analysis, DNA / methods
TL;DR:
This work proposes a mathematical model for how bias distorts community measurements based on the properties of real experiments and validate this model with 16S rRNA gene and shotgun metagenomics data from defined bacterial communities.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: September 10, 2019
2019 journal article
A novel device to measure static hindlimb weight-bearing forces in pronograde rodents
Journal of Neuroscience Methods, 328, 108405.
author keywords: Inflammatory pain; Spontaneous; pain; Weight-bearing; Incapacitance meter; Non-reflexive assay
MeSH headings : Animals; Behavior, Animal / physiology; Biomechanical Phenomena / physiology; Disease Models, Animal; Hindlimb / physiology; Inflammation / chemically induced; Mice; Neurosciences / instrumentation; Neurosciences / methods; Pain / chemically induced; Pain / physiopathology; Posture / physiology; Rats; Weight-Bearing / physiology
TL;DR:
A Static Horizontal Incapacitance Meter (SHIM) is designed to measure bodyweight distribution in pronograde standing rodents and successfully detected asymmetric weight-bearing in acute and sub-chronic pain models and the analgesic effects of meloxicam.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: August 27, 2019
2019 journal article
Antimicrobial Activity of Ceftiofur and Penicillin With Gentamicin Against Escherichia coli and Streptococcus equi Subspecies zooepidemicus in an Ex Vivo Model of Equine Postpartum Uterine Disease
JOURNAL OF EQUINE VETERINARY SCIENCE, 79, 121–126.
author keywords: E. coli; S. zooepidemicus; Postpartum mare; Antibiotic use
MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Cephalosporins; Drug Resistance, Bacterial; Escherichia coli; Female; Gentamicins; Horse Diseases / drug therapy; Horses; Humans; Penicillins; Postpartum Period; Streptococcus equi; Uterine Diseases / drug therapy; Uterine Diseases / veterinary
TL;DR:
The intrauterine infusion of procaine penicillin G with gentamicin in cases of postpartum uterine disease caused by E. coli or S. zooepidemicus is supported by the results of this work.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 26, 2019
2019 journal article
High-throughput amplicon sequencing of the full-length 16S rRNA gene with single-nucleotide resolution
Nucleic Acids Research, 7.
MeSH headings : Escherichia coli K12 / classification; Escherichia coli K12 / genetics; Escherichia coli O157 / classification; Escherichia coli O157 / genetics; Feces / microbiology; High-Throughput Nucleotide Sequencing; Humans; Microbiota / genetics; Phylogeny; Polymerase Chain Reaction / methods; Polymorphism, Single Nucleotide / genetics; RNA, Ribosomal, 16S / genetics; Sequence Analysis, DNA
TL;DR:
A high-throughput amplicon sequencing methodology based on PacBio circular consensus sequencing and the DADA2 sample inference method that measures the full-length 16S rRNA gene with single-nucleotide resolution and a near-zero error rate is presented.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: August 21, 2019
2019 article
Consistent and correctable bias in metagenomic sequencing experiments
McLaren, M. R., Willis, A. D., & Callahan, B. J. (2019, February 25). (Vol. 2). Vol. 2.
Source: ORCID
Added: August 21, 2019
2019 article
Report of the Fourth International Havemeyer Workshop on Equid Herpesviruses (EHV) EHV-1, EHV-2 and EHV-5
Kydd, J. H., Lunn, D. P., & Osterrieder, K. (2019, September). EQUINE VETERINARY JOURNAL, Vol. 51, pp. 565–568.
MeSH headings : Animals; Herpesviridae Infections / veterinary; Herpesvirus 1, Equid; Horse Diseases; Rhadinovirus
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 19, 2019
2019 journal article
AAVMC Internship Program Guidelines 2018
Journal of Veterinary Medical Education, 46(2), 139–144.
author keywords: competency; competencies; continuing education; educational methods; graduate education; outcomes; resident; intern education; student health and well-being
MeSH headings : Animals; Education, Veterinary; Humans; Internship and Residency; United States; Universities
TL;DR:
These internship guidelines are intended to be applicable to all internships, in both academic and private practice settings, and they place particular emphasis on three aspects of internship training programs: competency-based education, intern well-being, and program outcome.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref
Added: July 1, 2019
2019 journal article
Comparative plasma and urine concentrations of flunixin and meloxicam in goats
SMALL RUMINANT RESEARCH, 174, 40–46.
TL;DR:
The information from this study represents a potential worst-case scenario for urine depletion and helps determine the withdrawal intervals needed for flunixin meglumine in show goats when administered in this extra label manner.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 4, 2019
2019 journal article
Multicentre, blinded, randomised clinical trial comparing the use of flunixin meglumine with firocoxib in horses with small intestinal strangulating obstruction
EQUINE VETERINARY JOURNAL, 51(3), 329–335.
author keywords: horse; colic; endotoxaemia; flunixin meglumine; firocoxib; clinical study
MeSH headings : 4-Butyrolactone / administration & dosage; 4-Butyrolactone / analogs & derivatives; 4-Butyrolactone / therapeutic use; Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Clonixin / administration & dosage; Clonixin / analogs & derivatives; Clonixin / therapeutic use; Female; Horse Diseases / drug therapy; Horses; Intestinal Obstruction / complications; Intestinal Obstruction / veterinary; Male; Pain, Postoperative / drug therapy; Pain, Postoperative / veterinary; Random Allocation; Sulfones / administration & dosage; Sulfones / therapeutic use
TL;DR:
Treatment of post-surgical SISO horses with firocoxib (COX-2 selective) would reduce the signs of endotoxaemia to a greater extent than flunixin meglumine (nonselective COX inhibitor) while continuing to provide similar levels of pain control.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: May 6, 2019
2019 personal communication
Letter to the Editor: Bias in statistics or bias in equine veterinary medicine?
Ziegler, A. L., Fogle, C. A., Burke, M., & Blikslager, A. T. (2019, May).
MeSH headings : 4-Butyrolactone / analogs & derivatives; Animals; Clonixin / analogs & derivatives; Horses; Sulfones
TL;DR:
It is proposed that validating a trend towards improved survival in horses treated with firocoxib would require additional studies with greater numbers of horses and likely modification of the study design to include preoperative drug randomisation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: May 6, 2019
2019 journal article
Multiomics modeling of the immunome, transcriptome, microbiome, proteome and metabolome adaptations during human pregnancy
BIOINFORMATICS, 35(1), 95–103.
Ed(s): J. Wren
MeSH headings : Computational Biology; Female; Humans; Metabolome; Microbiota; Pregnancy; Proteome; Transcriptome
TL;DR:
This model not only significantly increased predictive power by combining all datasets, but also revealed novel interactions between different biological modalities, which provides the frameworks for future studies examining deviations implicated in pregnancy‐related pathologies including preterm birth and preeclampsia.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 11, 2019
2019 journal article
Allantoic Metabolites, Progesterone, and Estradiol-17 beta Remain Unchanged After Infection in an Experimental Model of Equine Ascending Placentitis
JOURNAL OF EQUINE VETERINARY SCIENCE, 73, 95–105.
author keywords: Equine; Ascending placentitis; Metabolomics; Allantoic fluid
TL;DR:
The results of this study established a database of equine allantoic fluid metabolites and confirmed the utility of uteroplacental ultrasound for detection of placentitis before the onset of hematologic changes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: February 11, 2019
2019 article
Clinical ethics consultation in a tertiary care veterinary teaching hospital
Adin, C. A., Moga, J. L., Keene, B. W., Fogle, C. A., Hopkinson, H. R., Weyhrauch, C. A., … Rosoff, P. M. (2019, January 1). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 254, pp. 52–60.
MeSH headings : Animal Rights; Animals; Ethics Consultation; Hospitals, Teaching; Humans; Tertiary Healthcare; United States
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: January 14, 2019
2019 journal article
Pharmacokinetics of Intrarectal Altrenogest in Horses
JOURNAL OF EQUINE VETERINARY SCIENCE, 72, 41–46.
author keywords: Horse; Altrenogest; Pharmacokinetics; Intrarectal administration
MeSH headings : Administration, Rectal; Animals; Cross-Over Studies; Female; Horses / metabolism; Pregnancy; Pregnancy Maintenance / drug effects; Trenbolone Acetate / analogs & derivatives; Trenbolone Acetate / pharmacokinetics
TL;DR:
Altrenogest is rapidly absorbed following PR administration in the horse and reaches therapeutic concentrations, making this a viable method of treatment in NPO mares, and the decreased bioavailability and shorter detection time suggest 0.088 mg/kg PR q 4–8 hours would be necessary to maintain therapeutic concentrations over a 24‐hour period.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: January 7, 2019
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