2023 journal article

The impact of shift-work light conditions on tissue-specific circadian rhythms of canonical clock genes: insights from a mouse model study [version 1; peer review: 1 approved, 1 approved with reservations]

[Version 1;]. F1000Research.

By: B. Koritala *, P. Dakup  n, K. Porter *, S. Gaddameedhi n , D. P. & B. Koritala

Contributors: D. P.  n, D. P. *, D. P., D. P., G. Shobhan  n, G. Shobhan, G. Shobhan, G. Shobhan ...

Ed(s): D. P.  n, G. Shobhan  n, B. Koritala * & K. Porter *

MeSH headings : Humans; Male; Animals; Mice; Mice, Inbred C57BL; Circadian Rhythm; Circadian Clocks / genetics; Disease Models, Animal; Liver; Mammals
Source: ORCID
Added: August 3, 2023

The natural day-night cycle synchronizes our circadian rhythms, but modern work practices like night shifts disrupt this pattern, leading to increased exposure to nighttime light. This exposure is linked to various health issues. While some studies have explored the effects of night shifts on human circadian rhythms, there is limited research on the consequences of long-term exposure to shift-work light conditions. Rodents can provide valuable insights into these effects. This study aimed to examine how short- or long-term exposure to rotating shifts and chronic jetlag affects the core circadian oscillators in the liver and skin of mammals.