2023 article
Sex-specific differences and predictors of echocardiographic measures of diastolic dysfunction in rhesus macaques (Macaca mulatta)
Rivas, V. N., Ueda, Y., & Stern, J. A. (2023, July 17). JOURNAL OF MEDICAL PRIMATOLOGY.
author keywords: diastology; E/A; hemodynamics; HFpEF; IVRT; monkey
TL;DR:
Diastolic dysfunction in humans is an age‐related process with an overrepresentation in women, and in rhesus macaques (Macaca mulatta), the incidence and predictors have yet to be reported.
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UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 21, 2023
AbstractBackgroundDiastolic dysfunction in humans is an age‐related process with an overrepresentation in women. In rhesus macaques (Macaca mulatta), the incidence and predictors of diastolic dysfunction have yet to be reported.MethodsData from routine echocardiographic evaluations on clinically healthy rhesus macaques was obtained and used for univariate, bivariate, hypothesis testing, and linear regression statistical analyses interrogating differences and predictors of diastolic function.ResultsRhesus macaques fully recapitulate previously reported human hemodynamic studies. Female monkeys display impaired diastology and are at an increased risk for developing diastolic dysfunction. Age, sex, and proxies of exercise activity are confirmed predictors for measures of diastolic dysfunction, regardless of specific pathogen‐free status.ConclusionsRhesus macaques share common sex‐ and age‐related echocardiographic findings as humans, therefore, serve as a valuable translational nonhuman primate model for future studies of diastolic dysfunction. These findings confirm the importance of sex‐ and age‐matching within future rhesus macaque cardiovascular research.