2023 journal article
Evaluation of thrombin generation in dogs administered clopidogrel
FRONTIERS IN VETERINARY SCIENCE, 10.
author keywords: coagulation; platelet inhibitory; antithrombotic; therapeutic monitoring; canine
TL;DR:
Thrombin generation performed on platelet poor plasma may not be a useful antiplatelet monitoring tool in dogs, despite concomitant changes in TEG-PM variables consistent with platelet inhibition.
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www.frontiersin.org (publisher PDF)
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Added: September 11, 2023
IntroductionThe antiplatelet effect of clopidogrel can vary between patients. A modified thromboelastography (TEG) protocol (TEG-Platelet Mapping assay® [TEG-PM]) can be used for clopidogrel monitoring but is not widely available. Thrombin generation (TG) assays could offer a novel alternative. The main objective of this pilot study was to assess TG assay variables (lag time, peak, endogenous thrombin potential [ETP]) in dogs before and after 7 days of clopidogrel administration and compare with TEG-PM variables (maximum amplitude [MA]-ADP and percentage (%) inhibition).
