2023 article
An <i>S</i>=1 Iron(IV) Intermediate Revealed in a Non-Heme Iron Enzyme-Catalyzed Oxidative C-S Bond Formation
Paris, J. C., Hu, S., Wen, A., Weitz, A. C., Cheng, R., Gee, L. B., … Guo, Y. (2023, September 13). ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol. 9.
author keywords: Ergothioneine; Ferryl Intermediates; High-Valent Iron; Ovothiol A; Oxidative C-S Bond Formation
topics (OpenAlex): Metal-Catalyzed Oxygenation Mechanisms; Photosynthetic Processes and Mechanisms; Plant biochemistry and biosynthesis
TL;DR:
The identification and characterization of a kinetically competent S = 1 iron(IV) intermediate supported by a four-histidine ligand environment in enabling C-S bond formation in OvoA from Methyloversatilis thermotoleran, which represents the first experimentally observed intermediate spin iron( IV) species in non-heme iron enzymes.
(via Semantic Scholar)
open access via doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: October 10, 2023
Ergothioneine (ESH) and ovothiol A (OSHA) are two natural thiol-histidine derivatives. ESH has been implicated as a longevity vitamin and OSHA inhibits the proliferation of hepatocarcinoma. The key biosynthetic step of ESH and OSHA in the aerobic pathways is the O