2023 article

Structure-guided AAV capsid evolution strategies for enhanced CNS gene delivery

Gonzalez, T. J., Mitchell-Dick, A., Blondel, L. O., Fanous, M. M., Hull, J. A., Oh, D. K., … Asokan, A. (2023, September 21). NATURE PROTOCOLS.

By: T. Gonzalez *, A. Mitchell-Dick *, L. Blondel *, M. Fanous*, J. Hull*, D. Oh *, S. Moller-Tank *, R. Rivera*, J. Piedrahita n , A. Asokan *

TL;DR: A detailed protocol describing two distinct evolution strategies using structurally divergent AAV serotypes as templates, exemplified by improving CNS gene transfer efficiency in vivo, can be adapted to expand the AAV vector toolkit for genetic manipulation of animal models and development of human gene therapies. (via Semantic Scholar)
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Added: October 16, 2023