The purpose of this study was to explore students’ perceptions related to cat and dog owners’ (a) knowledge of antibiotics and antimicrobial resistance, (b) expectations and preferences related to antibiotic use, and (c) preferences and experiences related to veterinarian–client communication preferences and experiences. This project compared students’ responses to those provided by cat and dog owners in a previous study. Because that prior research suggested that students’ perceptions can shift over time, we also explored whether progression throughout the DVM curriculum impacted students’ views of cat and dog owners. DVM students ( n = 584) from seven schools in the Southeastern Veterinary Education Consortium completed an online survey based on prior research of cat and dog owner behavior and preferences. Results indicate that DVM students overestimate cat and dog owner's expectations for antibiotics and underestimate cat and dog owners’ adherence to veterinary directions for antibiotic use. Similarly, fewer DVM students than cat and dog owners agreed that veterinary communication about antibiotics, their side effects, and their cost occurs during visits with a sick pet. Where significant, more students in later DVM class years had a positive view about client knowledge/adherence and veterinary communication. This lack of confidence in clients’ knowledge and competence and in the quality of veterinarian–client communication indicates a need to educate students on their perceptions of veterinary–client communications, as well as reinforcing that clients generally listen and trust veterinarians’ recommendations regarding antimicrobial prescribing and stewardship.