2023 article
Potential Impact of a Diagnostic Test for Detecting Prepatent Guinea Worm Infections in Dogs
Smalley, H., Keskinocak, P., Swann, J., Hanna, C., & Weiss, A. (2023, October 31).
TL;DR:
An agent-based simulation model is adapted for forecasting the impact of interventions on guinea worm disease in dogs to examine the interaction of multiple test factors including test accuracy, when the test can detect infection, dog selection, and dog-owner compliance with tethering recommendations and it finds that a diagnostic test could be successful if used in conjunction with existing interventions.
(via Semantic Scholar)
open access via doi.org (repository)
Source: ORCID
Added: January 26, 2024
ABSTRACTChad has seen a considerable reduction in cases of Guinea worm disease (or dracunculiasis) in domestic dogs in recent years. Tethering of dogs and application of Abate®larvicide to water sources appear to have contributed to this progress, but with 767 reported dog cases in 2021, accelerating elimination of the disease in Chad may require additional tools. We investigate the potential benefits of a hypothetical diagnostic test which could be capable of detecting pre-patent infections in dogs. We adapt an agent-based simulation model for forecasting the impact of interventions on guinea worm disease in dogs to examine the interaction of multiple test factors including test accuracy, when the test can detect infection, dog selection, and dog-owner compliance with tethering recommendations. We find that a diagnostic test could be successful if used in conjunction with existing interventions, and elimination can be achieved within two years with 80% or higher test sensitivity, 90% or higher specificity, systematic testing of each dog twice per year, and over 90% long-term tethering compliance when a dog tests positive or a worm is emerging. Because of the long incubation period of Guinea worm disease (10-14 months) and the fact that no treatment exists, the benefits of the test rely on the testing rollout and response of dog owners. If the test could estimate the timing of worm emergence, long-term tethering could be eliminated and infected dogs could be tethered only when the worms are expected, minimizing the related resources (human and financial) to support the intervention.