2020 journal article

Histamine-dependent interactions between mast cells, glia, and neurons are altered following early-life adversity in mice and humans

American Journal of Physiology-Gastrointestinal and Liver Physiology, 319(6), G655–G668.

By: J. McClain*, E. Mazzotta*, N. Maradiaga*, N. Duque-Wilckens* , I. Grants*, A. Robison *, F. Christofi *, A. Moeser *, B. Gulbransen *

TL;DR: Early life stress alters interactions between enteric glia and mast cells that are mediated by histamine, and this mechanism could contribute to enteric neuroplasticity driven by early life adversity. (via Semantic Scholar)
Source: ORCID
Added: January 28, 2024

Early-life adversity places an individual at risk for developing functional gastrointestinal disorders later in life through unknown mechanisms. Here, we show that interactions between mast cells and glia are disrupted by early-life stress in mice and that histamine is a potential mediator of mast cell-glial interactions.