2024 journal article
High-Affinity Aptamers for <i>In Vitro</i> and <i>In Vivo</i> Cocaine Sensing
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 146(5), 3230–3240.
TL;DR:
High-stringency in vitro selection is performed to generate DNA aptamers that bind cocaine with nanomolar affinity and clinically relevant specificity, thus representing a dramatic improvement over the current-generation, micromolar-affinity, low-specificity cocaine aptamers.
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UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: February 19, 2024
The ability to quantify cocaine in biological fluids is crucial for both the diagnosis of intoxication and overdose in the clinic as well as investigation of the drug's pharmacological and toxicological effects in the laboratory. To this end, we have performed high-stringency