2023 article

Cardiomyocyte Alpha-1A Adrenergic Receptors Mitigate Postinfarct Remodeling and Mortality by Constraining Necroptosis

Zhang, J., Sandroni, P. B., Huang, W., Gao, X., Oswalt, L., Schroder, M. A., … Jensen, B. C. (2024, January). JACC-BASIC TO TRANSLATIONAL SCIENCE, Vol. 9, pp. 78–96.

By: J. Zhang *, P. Sandroni *, W. Huang *, X. Gao *, L. Oswalt *, M. Schroder *, S. Lee *, Y. Shih * ...

author keywords: adrenergic alpha 1 receptor antagonists; myocardial infarction; necroptosis; receptors; adrenergic alpha
TL;DR: It is indicated that cardiomyocyte α1A-ARs constrain ischemia-induced necroptosis and suggest caution in the use of α-blockers in patients at risk for MI, and patients at the authors' center who were taking α-blocks at the time of MI experienced a higher risk of mortality. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: March 11, 2024

Clinical studies have shown that α1-adrenergic receptor antagonists (α-blockers) are associated with increased heart failure risk. The mechanism underlying that hazard and whether it arises from direct inhibition of cardiomyocyte α1-ARs or from systemic effects remain unclear. To address these issues, we created a mouse with cardiomyocyte-specific deletion of the α1A-AR subtype and found that it experienced 70% mortality within 7 days of myocardial infarction driven, in part, by excessive activation of necroptosis. We also found that patients taking α-blockers at our center were at increased risk of death after myocardial infarction, providing clinical correlation for our translational animal models.