2024 journal article
A statistical approach to system suitability testing for mass spectrometry imaging
RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 38(9).
onlinelibrary.wiley.com (publisher PDF)
Source: Web Of Science
Added: March 18, 2024
RationaleMass spectrometry imaging (MSI) elevates the power of conventional mass spectrometry (MS) to multidimensional space, elucidating both chemical composition and localization. However, the field lacks any robust quality control (QC) and/or system suitability testing (SST) protocols to monitor inconsistencies during data acquisition, both of which are integral to ensure the validity of experimental results. To satisfy this demand in the community, we propose an adaptable QC/SST approach with five analyte options amendable to various ionization MSI platforms (e.g., desorption electrospray ionization, matrix‐assisted laser desorption/ionization [MALDI], MALDI‐2, and infrared matrix‐assisted laser desorption electrospray ionization [IR‐MALDESI]).