The pebble bed reactor is a unique reactor design due to its capacity for continuous multipass circulation of the fuel elements, without causing interruption to reactor operation, with the assistance of the burnup measurement system. Such a system necessarily requires an accurate knowledge of the burnup of each fuel pebble upon ejection from the core so as to inform the reloading decision and to ensure that no pebble exceeds the regulated discharge burnup limit at any point following reinsertion into the reactor core. In this work, we conceptualize, develop, and demonstrate a machine learning–based fuel burnup prediction framework leveraging advanced modeling and simulation capabilities.