2024 article
Customizable Porphyrin Platform Enables Folate Receptor PET Imaging Using Copper-64
Houson, H. A., Wu, Z., Cao, P.-L. D., Lindsey, J. S., & Lapi, S. E. (2024, April 16). MOLECULAR PHARMACEUTICS.
author keywords: copper-64; folate; ovarian cancer; porphyrin; positron emission tomography; radiotherapy; theragnostic; water-soluble
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: April 29, 2024
Folate receptors including folate receptor α (FRα) are overexpressed in up to 90% of ovarian cancers. Ovarian cancers overexpressing FRα often exhibit high degrees of drug resistance and poor outcomes. A porphyrin chassis has been developed that is readily customizable according to the desired targeting properties. Thus, compound O5 includes a free base porphyrin, two water-solubilizing groups that project above and below the macrocycle plane, and a folate targeting moiety. Compound O5 was synthesized (>95% purity) and exhibited aqueous solubility of at least 0.48 mM (1 mg/mL). Radiolabeling of O5 with