2024 journal article
Improved detection in untargeted lipidomics through silver-doped infrared matrix-assisted laser desorption electrospray ionization
RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 38(15).
Silver doping of electrospray is known to increase the abundance of olefinic compounds detected by mass spectrometry. While demonstrated in targeted experiments, this has yet to be investigated in an untargeted study. Utilizing infrared matrix-assisted laser desorption electrospray ionization mass spectrometry imaging (IR-MALDESI-MSI), an untargeted lipidomics experiment on mouse liver was performed to evaluate the advantages of silver-doped electrospray.