2024 journal article

Cite it

The Conflict between Regulatory Agencies over the 20,000-Fold Lowering of the Tolerable Daily Intake (TDI) for Bisphenol A (BPA) by the European Food Safety Authority (EFSA)

ENVIRONMENTAL HEALTH PERSPECTIVES, 132(4).

By: F. Saal ^*, M. Antoniou^*, S. Belcher ⁿ , A. Bergman^*, R. Bhandari ^*, L. Birnbaum ^*, A. Cohen, T. Collins ^* ...and 33 other authors, B. Demeneix ^*, A. Fine, J. Flaws ^*, V. Gayrard^*, W. Iii, A. Gore^*, J. Heindel, P. Hunt ^*, T. Iguchi^*, C. Kassotis ^*, A. Kortenkamp ^*, R. Mesnage ^*, J. Muncke ^*, J. Myers, A. Nadal ^*, R. Newbold^*, V. Padmanabhan ^*, P. Palanza ^*, Z. Palma, S. Parmigiani^*, L. Patrick, G. Prins ^*, C. Rosenfeld ^*, N. Skakkebaek ^*, C. Sonnenschein ^*, A. Soto ^*, S. Swan^*, J. Taylor ^*, P. Toutain ^*, F. Hippel ^*, W. V. Welshons^*, D. Zalko^*, R. Zoeller ^*(hide authors)

10.1289/EHP13812

Find Text @ NCSU

doi.org (publisher)

Source: Web Of Science

Added: June 17, 2024

The European Food Safety Authority (EFSA) recommended lowering their estimated tolerable daily intake (TDI) for bisphenol A (BPA) 20,000-fold to 0.2 ng/kg body weight (BW)/day. BPA is an extensively studied high production volume endocrine disrupting chemical (EDC) associated with a vast array of diseases. Prior risk assessments of BPA by EFSA as well as the US Food and Drug Administration (FDA) have relied on industry-funded studies conducted under good laboratory practice protocols (GLP) requiring guideline end points and detailed record keeping, while also claiming to examine (but rejecting) thousands of published findings by academic scientists. Guideline protocols initially formalized in the mid-twentieth century are still used by many regulatory agencies. EFSA used a 21st century approach in its reassessment of BPA and conducted a transparent, but time-limited, systematic review that included both guideline and academic research. The German Federal Institute for Risk Assessment (BfR) opposed EFSA's revision of the TDI for BPA.