2018 journal article

Construction of versatile multilayered composite nanoparticles from a customized nanogel template

Bioactive Materials, 3(1), 87–96.

By: J. Zhang* , J. Jia*, J. Kim*, F. Yang *, X. Wang *, H. Shen *, S. Xu *, J. Yang *, D. Wu *

Source: ORCID
Added: July 1, 2024

We present a highly adaptable design platform for multi-responsive, multilayered composite nanoparticles (MC-NPs) with fine-tunable functional layers. A flexible disulfide-linked nanogel template is obtained by a controlled in-situ gelation method, enabling a high degree of control over each successive layer. From this template, we optimize "smart" biomaterials with biofunctional surfaces, tunable drug release kinetics, and magnetic or pH-responsive functionality, fabricated into MC-NPs for targeted drug release and periosteum-mimetic structures for controlled rhBMP-2 release towards bone tissue formation in-vivo. Such a versatile platform for the design of MC-NPs is a powerful tool that shows considerable therapeutic potential in clinical fields such as oncology and orthopedics.