2024 journal article

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Inhalable Stem Cell Exosomes Promote Heart Repair After Myocardial Infarction

CIRCULATION, 150(9), 710–723.

By: J. Li ⁿ, S. Sun ^*, D. Zhu^* , X. Mei^*, Y. Lyu ⁿ, K. Huang ⁿ , Y. Li ⁿ , S. Liu^* ...and 7 other authors, including 5 NC State authors, Z. Wang ⁿ, S. Hu ^*, H. Lutz ⁿ, K. Popowski ⁿ , P. Dinh ⁿ, A. Butte ^*, K. Cheng^*

author keywords: CD36; extracellular vesicles; exosomes; inhalation; myocardial infarction

10.1161/CIRCULATIONAHA.123.065005

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UN Sustainable Development Goal Categories

3. Good Health and Well-being (OpenAlex)

Source: Web Of Science

Added: September 23, 2024

Exosome therapy shows potential for cardiac repair after injury. However, intrinsic challenges such as short half-life and lack of clear targets hinder the clinical feasibility. Here, we report a noninvasive and repeatable method for exosome delivery through inhalation after myocardial infarction (MI), which we called stem cell-derived exosome nebulization therapy (SCENT).