Abstract This accessible book describes emerging infectious diseases that affect humans, including rabies, Ebola virus, Lyme disease, bubonic plague, and of course, COVID-19. These case studies span the entire range of zoonotic disease emergence pathways, from sheep testicles in the western USA to butchered bush rats in Vietnam! The book also covers emerging infectious diseases in wildlife, such as Tasmanian devil facial tumour disease, white nose syndrome, mange, and musk ox lungworm. Readers will become familiar with the basic tools and concepts of outbreak epidemiology (e.g. epidemic curves, disease surveillance), disease ecology and the global drivers of pathogen emergence (e.g. globalization, climate change, land-use change), and disease control and conservation interventions (e.g. vaccination, culling). Despite a recent explosion of courses on the topic and a recent viral pandemic, this is the first textbook to focus on pathogen spillover ecologyat the human–wildlife interface. Emerging Zoonotic and Wildlife Pathogens serves as an introduction to this multidisciplinary field for upper-level undergraduate students, graduate students, and working professionals interested in disease ecology, veterinary epidemiology, public health, and conservation.