2006 article
Microstructure, mechanical properties, and biological response to functionally graded HA coatings
Rabiei, A., Blalock, T., Thomas, B., Cuomo, J., Yang, Y., & Ong, J. (2007, April). MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS, Vol. 27, pp. 529–533.
author keywords: hydroxyapatite; graded crystallinity; nano-grain
TL;DR:
A biocompatible coating comprising an HA film with functionally graded crystallinity is being deposited on a heated substrate in an Ion Beam Ass Deposition (IBAD) system and results have shown superior mechanical properties and biological response to the functionally graded HA film.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
Hydroxyapatite (HA) [Ca10(PO4)6(OH)2] is the primary mineral content, representing 43% by weight, of bone. Applying a thin layer of HA, to the surface of a metal implant, can promote osseointegration and increase the mechanical stability of the implant. In this study, a biocompatible coating comprising an HA film with functionally graded crystallinity is being deposited on a heated substrate in an Ion Beam Assisted Deposition (IBAD) system. The microstructure of the film was studied using Transmission Electron Microscopy techniques. Finally, initial cell adhesion and cell differentiation on the coating was evaluated using ATCC CRL 1486 human embryonic palatal mesenchymal cell, an osteoblast precursor cell line. The results have shown superior mechanical properties and biological response to the functionally graded HA film.