2019 journal article
DendriPeps: Expanding Dendrimer Functionality by Hybridizing Poly(amidoamine) (PAMAM) Scaffolds with Peptide Segments
MACROMOLECULAR RAPID COMMUNICATIONS, 40(22).
author keywords: internally functionalized dendrimers; orthogonal protection strategies; poly(amidoamine); polymer-peptide chemistry
MeSH headings : Amino Acids / chemistry; Dendrimers / chemistry; Dendrimers / metabolism; Drug Delivery Systems / methods; Molecular Dynamics Simulation; Molecular Structure; Peptides / chemistry; Peptides / metabolism; Tissue Scaffolds / chemistry
TL;DR:
The precise control over the number, type, and topological placement of functional groups expands the functional behavior of DendriPeps beyond current PAMAM dendrimers toward new frontiers or colloids, drug delivery vectors, and catalysis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: October 14, 2019
AbstractIn this work, the first synthesis of poly(amidoamine) (PAMAM) dendrimers whose branches are hybridized with peptide segments (DendriPeps) is reported. The intercalation of amino acids within the branches of PAMAMs provides supplementary internal functionalities to the coronal groups. Four DendriPep prototypes are synthesized with lysine or glutamic acid as “guest” amino acids, displaying, respectively, a primary amine or a carboxyl group, on generation (G)2 and G3 PAMAMs as host scaffolds. The precise control over the number, type, and topological placement of functional groups expands the functional behavior of DendriPeps beyond current PAMAM dendrimers toward new frontiers or colloids, drug delivery vectors, and catalysis.