2019 article
Nongenomic glucocorticoid effects and their mechanisms of action in vertebrates
INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY, VOL 346, Vol. 346, pp. 51–96.
MeSH headings : Animals; Anti-Inflammatory Agents / metabolism; Anti-Inflammatory Agents / pharmacology; Cell Membrane / metabolism; Gene Expression Regulation; Glucocorticoids / metabolism; Glucocorticoids / pharmacology; Humans; Hydrocortisone / metabolism; Hydrocortisone / pharmacology; Receptors, Glucocorticoid / metabolism; Transcription, Genetic; Vertebrates
TL;DR:
Evidence across the vertebrate taxa on the diversity of nongenomic actions of glucocorticoids and the membrane-associated cellular mechanisms that may underlie rapid glucoc Corticoid responses to include potential binding sites characterized to date is assimilated.
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UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: December 30, 2019
Glucocorticoids (GC) act on multiple organ systems to regulate a variety of physiological processes in vertebrates. Due to their immunosuppressive and anti-inflammatory actions, glucocorticoids are an attractive target for pharmaceutical development. Accordingly, they are one of the most widely prescribed classes of therapeutics. Through the classical mechanism of steroid action, glucocorticoids are thought to mainly affect gene transcription, both in a stimulatory and suppressive fashion, regulating de novo protein synthesis that subsequently leads to the physiological response. However, over the past three decades multiple lines of evidence demonstrate that glucocorticoids may work through rapid, nonclassical mechanisms that do not require alterations in gene transcription or translation. This review assimilates evidence across the vertebrate taxa on the diversity of nongenomic actions of glucocorticoids and the membrane-associated cellular mechanisms that may underlie rapid glucocorticoid responses to include potential binding sites characterized to date.