2020 review

Resistance to natural and synthetic gene drive systems

[Review of ]. JOURNAL OF EVOLUTIONARY BIOLOGY, 33(10), 1345–1360.

By: T. Price *, N. Windbichler *, R. Unckless *, A. Sutter *, J. Runge *, P. Ross *, A. Pomiankowski *, N. Nuckolls * ...

author keywords: CRISPR-Cas9; fitness costs; meiotic drive; population suppression; selfish genetic elements; sex ratio distorter; transposable element; Wolbachia
MeSH headings : Biological Evolution; Gene Drive Technology; Selection, Genetic
TL;DR: This review summarizes the current knowledge of drive resistance in both natural and synthetic gene drives and explores how insights from naturally occurring and synthetic drive systems can be integrated to improve the design of gene drives, better predict the outcome of releases and understand genomic conflict in general. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: Web Of Science
Added: October 12, 2020

AbstractScientists are rapidly developing synthetic gene drive elements intended for release into natural populations. These are intended to control or eradicate disease vectors and pests, or to spread useful traits through wild populations for disease control or conservation purposes. However, a crucial problem for gene drives is the evolution of resistance against them, preventing their spread. Understanding the mechanisms by which populations might evolve resistance is essential for engineering effective gene drive systems. This review summarizes our current knowledge of drive resistance in both natural and synthetic gene drives. We explore how insights from naturally occurring and synthetic drive systems can be integrated to improve the design of gene drives, better predict the outcome of releases and understand genomic conflict in general.