2011 review

Where has all the message gone?

[Review of ]. PLANT SCIENCE, 185, 23–32.

By: E. Davies n, B. Stankovic *, A. Vian * & A. Wood *

author keywords: mRNP; Polysome; P-bodies; RNA; Ribosome; Translation
MeSH headings : Biological Transport; Macromolecular Substances / metabolism; Plants / genetics; Plants / metabolism; Polyribosomes / genetics; Polyribosomes / metabolism; RNA, Messenger / genetics; RNA, Messenger / metabolism; Ribonucleoproteins / genetics; Ribonucleoproteins / metabolism; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism; Seeds / genetics; Seeds / metabolism
TL;DR: The main points are; when mRNA leaves polysomes to go to prosomes, P-bodies, stress granules, etc., it is not necessarily destined for degradation - it can be re-utilized and "normal" tissue contains functional non-polysomal mRNA. (via Semantic Scholar)
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Added: August 6, 2018

We provide a brief history of polyribosomes, ergosomes, prosomes, informosomes, maternal mRNA, stored mRNA, and RNP particles. Even though most published research focuses on total mRNA rather than polysomal mRNA and often assumes they are synonymous - i.e., if a functional mRNA is present, it must be translated - results from our laboratories comparing polysomal RNA and total mRNA in a range of "normal" issues show that some transcripts are almost totally absent from polysomes while others are almost entirely associated with polysomes. We describe a recent model from yeast showing various destinies for polysomal mRNA once it has been released from polysomes. The main points we want to emphasize are; a) when mRNA leaves polysomes to go to prosomes, P-bodies, stress granules, etc., it is not necessarily destined for degradation - it can be re-utilized; b) "normal" tissue, not just seeds and stressed tissue, contains functional non-polysomal mRNA; c) association of mRNA with different classes of polysomes affects their sub-cellular location and translatability; and d) drawbacks, misinterpretations, and false hopes arise from analysis of total mRNA rather than polysomal mRNA and from presuming that all polysomes are "created equal".