MeSH headings : Animals; Anti-Bacterial Agents / adverse effects; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Bacterial Toxins / genetics; Bacterial Toxins / immunology; Bacterial Toxins / metabolism; Bacteroides / drug effects; Bacteroides / metabolism; Clostridioides difficile / genetics; Clostridioides difficile / immunology; Clostridioides difficile / metabolism; Clostridium Infections / immunology; Clostridium Infections / microbiology; Clostridium Infections / pathology; Disease Models, Animal; Extracellular Matrix / metabolism; Female; Gastrointestinal Microbiome / drug effects; Gastrointestinal Microbiome / immunology; Gene Expression Regulation, Bacterial / immunology; Host-Pathogen Interactions / genetics; Host-Pathogen Interactions / immunology; Humans; Intestinal Mucosa / immunology; Intestinal Mucosa / microbiology; Intestinal Mucosa / pathology; Male; Matrix Metalloproteinases / metabolism; Mice; Nutrients / metabolism; Proteolysis; RNA, Bacterial / genetics; RNA, Bacterial / isolation & purification; RNA-Seq; Sigma Factor / genetics; Sigma Factor / immunology; Sigma Factor / metabolism; Transcriptome / immunology

TL;DR: Insight is provided into how toxin-induced inflammation alters C. difficile metabolism, host tissue gene expression and gut microbiota, together influencing a beneficial niche for infection. (via Semantic Scholar)