MeSH headings : Administration, Cutaneous; Animals; Antibodies, Anti-Idiotypic / adverse effects; Dog Diseases / chemically induced; Dog Diseases / drug therapy; Dogs; Free Radical Scavengers / therapeutic use; Immunoglobulin E / immunology; Inflammation / drug therapy; Inflammation / veterinary; Injections, Intradermal / veterinary; Intradermal Tests / veterinary; Pentoxifylline / therapeutic use; Skin Diseases / chemically induced; Skin Diseases / drug therapy; Skin Diseases / veterinary; Skin Tests / veterinary

TL;DR: In clinically normal dogs, pentoxifylline effectively impaired late-phase reactions but not immediate reactions at sites of intradermal injection of IgE-specific antibodies by inhibiting mast cell degranulation and recruitment of cutaneous inflammatory cells, especially eosinophils. (via Semantic Scholar)