2021 review
The Promising Effects of Astaxanthin on Lung Diseases
[Review of ]. ADVANCES IN NUTRITION, 12(3), 850–864.
author keywords: astaxanthin; lung diseases; oxidative stress; molecular mechanism; lung cancer
MeSH headings : Humans; Lung Diseases / drug therapy; Oxidative Stress; Phosphatidylinositol 3-Kinases / metabolism; Signal Transduction; Xanthophylls / pharmacology
TL;DR:
The potential role of ASX in protecting against lung diseases, including lung cancer, is reviewed and the underlying molecular mechanisms by which ASX protects against pulmonary diseases are summarized.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: July 6, 2021
Astaxanthin (ASX) is a naturally occurring xanthophyll carotenoid. Both in vitro and in vivo studies have shown that it is a potent antioxidant with anti-inflammatory properties. Lung cancer is the leading cause of cancer death worldwide, whereas other lung diseases such as chronic obstructive pulmonary disease, emphysema, and asthma are of high prevalence. In the past decade, mounting evidence has suggested a protective role for ASX against lung diseases. This article reviews the potential role of ASX in protecting against lung diseases, including lung cancer. It also summarizes the underlying molecular mechanisms by which ASX protects against pulmonary diseases, including regulating the nuclear factor erythroid 2-related factor/heme oxygenase-1 pathway, NF-κB signaling, mitogen-activated protein kinase signaling, Janus kinase-signal transducers and activators of transcription-3 signaling, the phosphoinositide 3-kinase/Akt pathway, and modulating immune response. Several future directions are proposed in this review. However, most in vitro and in vivo studies have used ASX at concentrations that are not achievable by humans. Also, no clinical trials have been conducted and/or reported. Thus, preclinical studies with ASX treatment within physiological concentrations as well as human studies are required to examine the health benefits of ASX with respect to lung diseases.