2021 journal article
Controlled Organization of Inorganic Materials Using Biological Molecules for Activating Therapeutic Functionalities
ACS APPLIED MATERIALS & INTERFACES, 13(33), 39030–39041.
author keywords: quantum dots; therapeutic nucleic acids; 3D assemblies; programmable assembly; materials organization; bioimaging; therapeutic delivery
MeSH headings : Cell Line, Tumor; Cell Membrane Permeability; Cell Survival / drug effects; Cell Tracking; Cross-Linking Reagents / chemistry; Drug Carriers / chemistry; Gene Silencing / drug effects; Humans; Luminescent Agents / chemistry; Models, Molecular; Nucleic Acids / chemistry; Optical Imaging; Quantum Dots / chemistry; Structure-Activity Relationship; Surface Properties
TL;DR:
The programmability and intracellular activity of QD assemblies offer a strategy for nucleic acids to imbue the structure and therapeutic function into the formation of complex networks of nanostructures, while the photoluminescent properties of the material allow for optical tracking in cells in vitro.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: September 27, 2021
Precise control over the assembly of biocompatible three-dimensional (3D) nanostructures would allow for programmed interactions within the cellular environment. Nucleic acids can be used as programmable crosslinkers to direct the assembly of quantum dots (QDs) and tuned to demonstrate different interparticle binding strategies. Morphologies of self-assembled QDs are evaluated via gel electrophoresis, transmission electron microscopy, small-angle X-ray scattering, and dissipative particle dynamics simulations, with all results being in good agreement. The controlled assembly of 3D QD organizations is demonstrated in cells via the colocalized emission of multiple assembled QDs, and their immunorecognition is assessed via enzyme-linked immunosorbent assays. RNA interference inducers are also embedded into the interparticle binding strategy to be released in human cells only upon QD assembly, which is demonstrated by specific gene silencing. The programmability and intracellular activity of QD assemblies offer a strategy for nucleic acids to imbue the structure and therapeutic function into the formation of complex networks of nanostructures, while the photoluminescent properties of the material allow for optical tracking in cells in vitro.