2021 review
Periostin, an Emerging Player in Itch Sensation
[Review of ]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 141(10), 2338–2343.
MeSH headings : Animals; Cell Adhesion Molecules / physiology; Humans; Integrins / physiology; Natriuretic Peptide, Brain / physiology; Pruritus / etiology; Sensation; TRPA1 Cation Channel / physiology
TL;DR:
The role of periostin in itch induction in human and animal models and its expression in human pruritic conditions are described.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: November 23, 2021
Periostin, an extracellular matrix and matricellular protein, binds to several types of integrins that transduce its signals. Its function in allergic inflammation is the establishment of sustained chronic inflammation through an amplification of T helper type 2‒immune responses. In addition, recent studies have shown a significant role of periostin in itch sensation through direct integrin-mediated stimulation of nerve fibers and interaction with immune and nonimmune cells (e.g., macrophages, eosinophils, basophils, and keratinocytes). The objective of this review is to describe the role of periostin in itch induction in human and animal models and its expression in human pruritic conditions.